库恩的《科学革命的结构》为什么会引起惊异？

1.引言 <科学革命的结构>(以下简称<结构>)一书出版后,库恩因其明显的相对主义的观点受到了批判.在辩护的过程中,库恩把自己说成是哲学家中的历史学家,所持的是历史学家关于科学进步的观点.     

Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems

Repeated cycles of ethanol intoxication and withdrawal associated with dependence induce neuroadaptations in a variety of brain systems. Withdrawal-induced negative emotional states can be ameliorated by ethanol consumption; a learned process termed negative reinforcement. Accordingly, a dependence-induced phenotype is escalated ethanol self-administration. Matrix metalloproteinases (MMPs) are proteolytic enzymes which degrade the extracellular matrix to allow for synaptic reorganization and plasticity. To test the hypothesis that an intact MMP system is required for animals to learn about the negative reinforcing effects of ethanol and display escalated self-administration during acute withdrawal when ethanol-dependent, male Wistar rats were trained to self-administer ethanol and then assigned to either acute or chronic MMP inhibition treatment groups. The chronic treatment group received intracerebroventricular (ICV) infusions of the broad spectrum MMP inhibitor FN-439 or artificial cerebrospinal fluid (aCSF) via osmotic minipumps during a 1 month ethanol dependence induction period and subsequent post-dependence induction self-administration sessions that occurred during acute withdrawal. The acute treatment group only received ICV FN-439 or aCSF on the day of self-administration sessions following dependence induction during acute withdrawal. The results showed that inhibition of MMPs attenuated escalated ethanol self-administration following chronic and acute exposure conditions. Furthermore, once learning (i.e., plasticity) had occurred, MMP inhibition had no impact on escalated response patterns and animals previously subjected to MMP inhibition that did not escalate evidenced normal escalations in operant ethanol self-administration once FN-439 treatments were terminated. Thus, the present data identified that an intact MMP system is required for the escalated responding that occurs during acute withdrawal in dependent animals and implicate such escalation as a learned response.     

Effects of anxiety and attention control on processing pictorial and linguistic emotional information

This study investigated the role of executive attention control in modulating selective processing of emotional information in anxiety. It was hypothesized that the combination of high anxiety and poor attention control would be associated with greater difficulty in ignoring task-irrelevant threat-related information. The study included both faces and words as stimuli. Cognitive interference effects were assessed using two emotional Stroop tasks: one with angry, fearful, happy and neutral faces, and one with threat-related, positive, and neutral words. An objective measure of attention control was obtained from the Attention network task. There were four participant groups with high/low trait anxiety and high/low attention control. Results indicated that the combination of high anxiety and poor attention control was associated with greater cognitive interference by emotional faces (including angry faces), compared to neutral faces. This interference effect was not evident in participants with high anxiety and high attentional control, or in low-anxious individuals. There was no evidence of associations between anxiety, attention control, and the interference effect of emotional words. Results indicate that high anxiety and poor attention control together predict enhanced processing of emotionally salient information, such as angry facial expressions. Implications for models of emotion processing are discussed.     

A solution-focused approach to working with clients who are suicidal

Self-harm and suicide are amongst the most challenging and frightening problems that therapists and counsellors can encounter in the course of their work. The risk of clients harming themselves in the course of treatment can debilitate the therapists from acting creatively and collaboratively, and make their actions defensive, focused solely on risk assessment rather than therapeutic change.Yet it is precisely a creative and collaborative response, such as that engendered by solution-focused therapy and other models, that is the most likely to facilitate change and re-empower clients to take back charge of their lives. This article describes a solution-focused approach to working with suicidal clients that can be used in conjunction with traditional approaches and which focus on establishing safety as well as assessing risk.Working from this model the clinician shifts to identifying client strengths and coping skills, to collaborating with the client to establish meaningful goals and to helping the client envision a positive future. Arguably, such an approach can increase collaboration between therapist and client and lead to a more client-centred safety plan.     

How psychological resources mediate and perceived social support moderates the relationship between depressive symptoms and help-seeking intentions in college students

There is a high prevalence of depression among college students, which is linked to lower levels of help-seeking intentions. However, there has been a lack of research examining variables that may help explain this relationship. The present study aimed to address this gap by examining whether psychological resources (optimism and self-esteem) mediate the relationship between depressive symptoms and help-seeking intentions, and whether this relationship is moderated by perceived social support. Participants were 8121 college students (66% female) aged 17–25 years (M?=?20.42, SD?=?1.90), who completed the My World Survey Post-Second Level, a national survey on youth mental health. Linear regression analysis confirmed that depressive symptoms predicted lower informal help-seeking intentions. Moderated mediation indicated that social support moderated the direct relationship between depressive symptoms and informal help-seeking intentions and that optimism and self-esteem mediated this relationship, when gender was controlled for. Findings indicate that social support and psychological resources help further our understanding of the relationship between depressive symptoms and help-seeking in young people. Campaigns promoting help-seeking in college students should focus on the beneficial role of social support and on fostering optimism and self-esteem as facilitators of help-seeking intentions.     

Effects of threat cues on attentional shifting, disengagement and response slowing in anxious individuals

According to cognitive models of anxiety, attentional biases for threat may cause or maintain anxiety states. Previous research using spatial cueing tasks has been interpreted in terms of difficulty in disengaging attention from threat in anxious individuals, as indicated by contrasts of response times (RTs) from threat cue versus neutral cue trials. However, on spatial cueing tasks, differences in RT between threat cue and neutral cue trials may stem from a slowing effect of threat on RT, as well as effects on allocation of visuospatial attention. The present study examined the effects of threat cues on both attentional cueing and response slowing. High and low anxious individuals completed a central cue task, which assessed threat-related response slowing, and a spatial cueing task, which assessed attentional biases for angry, happy and neutral faces. Results indicated that interpretation of the anxiety-related bias for threat depended on whether the effect of response slowing was taken into account. The study illustrates an important problem in using the modified spatial cueing task to assess components of threat-related attentional bias. As this experimental method may reflect both threat-related attentional cueing and response slowing effects, it cannot be assumed to provide pure measures of shift or disengagement components of attention bias.     

History,methodology and early algebra 1

The limits of ‘criterial rationality’ (that is, rationality as rule‐following) have been extensively explored in the philosophy of science by Kuhn and others. In this paper I attempt to extend this line of enquiry into mathematics by means of a pair of case studies in early algebra. The first case is the Ars Magna (Nuremburg 1545) by Jerome Cardan (1501–1576), in which a then recently‐discovered formula for finding the roots of some cubic equations is extended to cover all cubics and proved. The second is the formulation by Albert Girard (1595–1632) of an early version of the fundamental theorem of algebra in his L'invention nouvelle en l'algèbre (Amsterdam, 1629). I conclude that in these cases at least, the questions raised in the philosophy of science debate can also be asked of the history of mathematics, and that a modest methodological anarchism is the appropriate stance.     

Book reviews

International Journal for Philosophy of Religion -