Recommendations from Multi-disciplinary Focus Groups on Cascade Testing and Genetic Counseling for Fragile X-associated Disorders

The purpose of this paper is to report the outcome of a collaborative project between the Fragile X Research and Treatment Center at the Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute at the University of California at Davis, the National Fragile X Foundation (NFXF), and the Centers for Disease Control and Prevention (CDC). The objective of this collaboration was to develop and disseminate protocols for genetic counseling and cascade testing for the multiple disorders associated with the fragile X mental retardation 1 (FMR1) mutation. Over the last several years, there has been increasing insight into the phenotypic range associated with both the premutation and the full mutation of the FMR1 gene. To help develop recommendations related to screening for fragile X-associated disorders, four, two day advisory focus group meetings were conducted, each with a different theme. The four themes were: (1) fragile X-associated tremor/ataxia syndrome (FXTAS); (2) premature ovarian failure (POF) and reproductive endocrinology; (3) psychiatric, behavioral and psychological issues; and (4) population screening and related ethical issues.     

Signal transduction mechanisms within the entorhinal cortex that support latent inhibition of cued fear conditioning

Latent inhibition is a phenomenon by which pre-exposure to a conditioned-stimulus (CS), prior to subsequent pairings of that same CS with an unconditioned-stimulus (US), results in decreased conditioned responding to the CS. Previous work in our laboratory has suggested that the entorhinal cortex is critically involved in the establishment of latent inhibition of cued fear conditioning. Furthermore, utilizing systemic pharmacology, we have demonstrated a role for of NMDA receptors, protein kinase A (PKA), and mitogen activated protein kinase (MAPK, also known as ERK) in latent inhibition of cued fear conditioning, but until now, where these cell signaling cascades are critically activated during latent inhibition of cued fear was unknown. Here, we use direct drug infusion to demonstrate that cell signaling via NMDA receptors, the cAMP/PKA pathway, and the MAPK pathway within the entorhinal cortex are critically involved in latent inhibition of cued fear conditioning. In the present study, CS pre-exposed mice received 20 CS pre-exposures 24h prior to two pairings of the same CS with a 0.53 mA foot shock US, while control animals receive no pre-exposure to the CS. The NMDA antagonist APV (0.25 or 2.5 microg/side), the cAMP inhibitor Rp-cAMP (1.8 or 18.0 microg/side), or the MAPK inhibitor U0126 (0.1 or 1.0 microg/side) were directly infused into the entorhinal cortex prior to pre-exposure. All three drugs produced dose-dependent disruptions in latent inhibition of cued fear conditioning. Importantly, none of the drugs had any effect on cued fear conditioning when administered on training day, suggesting that the effects of each of the drugs were specific to CS pre-exposure. These results are discussed in relation to the potential mechanisms of plasticity that support latent inhibition of cued fear conditioning.     

Internet versus paper‐and‐pencil survey methods in psychological experiments: Equivalence testing of participant responses to health‐related messages

Despite experiments being increasingly conducted over the Internet, few studies have tested whether such experiments yield data equivalent to traditional methods' data. In the current study, data obtained via a traditional sampling method of undergraduate psychology students completing a paper‐and‐pencil survey (N = 107) were compared with data obtained from an Internet‐administered survey to a sample of self‐selected Internet‐users (N = 94). The data examined were from a previous study that had examined the persuasiveness of health‐related messages. To the extent that Internet data would be based on a sample at least as representative as data derived from a traditional student sample, it was expected that the two methodologies would yield equivalent data. Using formal tests of equivalence on persuasion outcomes, hypotheses of equivalence were generally supported. Additionally, the Internet sample was more diverse demographically than the student sample, identifying Internet samples as a valid alternative for future experimental research.     

Religious Identity and Cultural Diversity: Exploring the Relationships Between Religious Identity,Sexism, Homophobia,and Multicultural Competence

In this article, the authors present the results from a national study investigating the relationships between religious identity, sexism, homophobia, and multicultural competence. Participants were 111 randomly sampled counseling professionals and graduate students. The results indicated a relationship between religious identity and various aspects of valuing cultural diversity, including sexism, homophobia, and multicultural competence. Implications of the role of religion and religious identity in counseling are discussed, and suggestions for future research are provided.     

Rates of Specific Antecedent Instructional Practices and Differences Between Title I and non-Title I Schools

The use of effective instructional strategies is clearly emphasized in current educational reform, especially in the area of reading. The purposes of this study were to investigate the rates at which specific instructional practices (i.e., attention signals, prior knowledge supports, previews, instructor modeling, student modeling, organizational prompts) were utilized during literacy time in elementary schools, determine if there were relationships among the instructional variables, and explore if teachers in Title I schools and teachers in non-Title I schools differed in their use of specific practices. Participants included teachers and students from 35 classrooms who were each observed for 5 hours, resulting in a total of 175 observation hours. The Setting Factors Assessment Tool (SFAT) was used to measure the antecedent instructional variables. Main results included that teachers in non-Title I classrooms used significantly more prior knowledge references than teachers in Title I schools; the effect size for this finding was large. Several correlations among the instructional variables were significant. The article concludes with a discussion of the main findings, implications for future research and the limitations of this study.     

Education and the Immunization Paradigm

In this paper I chart the origins of modern day “biopedagogy” through an analysis of two historically specific figures of abnormality: the nervous child and the degenerate. These two figures form the positive (hygienic) and negative (eugenic) surfaces of biopolitics in education, sustained and articulated through the category of immunization. By analyzing the relation between the medical discourse of immunity and the practice of pedagogy, I will reveal how biopedagogy is predicated on a dialectical reversal of life into death and thus unsustainable for furthering social democracy. In conclusion, I begin to search for an affirmative notion of biopolitical education that is no longer predicated on the dialectics of immunization. For help in this project, I briefly suggest that a theory of natality helps to disentangle the promise of life from its negation in the form of educational eugenics and mental hygiene.     

Selfless self-transcendence in the clinical setting as a source of self-enhancement

The American Journal of Psychoanalysis - This paper examines the paradox of Selfless–Self-Transcendence, that is, how the self is enriched through...     

Overlapping Mechanisms in Implying and Inferring

Prior psychological work on Gricean implicature has revealed much about how listeners infer (comprehension) but little about how speakers imply (production). This is surprising given the inherent link between the two. This study aimed to obtain a more integral understanding of implicatures by investigating the processes that are shared between inference and implication. In two experiments, a participant and a confederate engaged in a dialogue game that invited the use of implicatures. In each there was a global priming manipulation, in which a confederate predominantly used implicit or explicit utterances, and a local priming manipulation, in which the utterance structure varied from trial to trial. Participants could choose whether to imply or use an explicit expression. Our results revealed that speaker and listener align on their use of implicatures. We interpret the local priming results as providing evidence of shared implicature representations between speaker and listener, and the global priming results as a form of audience design. We also present a model of implicature production that explains our findings.     

Public Attitudes about Transgender Participation in Sports: The Roles of Gender,Gender Identity Conformity,and Sports Fandom

Sex Roles - We examine the roles of gender, gender attitudes, and interest in sports on public attitudes about transgender people’s participation in athletics. Using a representative survey...