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921.
Marques MB Ribeiro-Oliveira A Guimarães J Nascimento GF Anjos AP Vilas-Boas WW Santos RA Thomas JD Igreja SM Grossman AB Kola B Korbonits M 《Stress (Amsterdam, Netherlands)》2012,15(5):554-561
5' adenosine monophosphate-activated protein kinase (AMPK) plays a prominent role as a metabolic stress sensor. The role of hypothalamic AMPK in response to restraint and surgical stress has not been previously investigated. It has been recently suggested that the renin-angiotensin system, in addition to its role in stress regulation, may play a significant role in regulating metabolic pathways including the regulation of the AMPK system. This study was thus aimed to evaluate the effects of candesartan, an angiotensin II AT1 receptor blocker drug, on hypothalamic AMPK activity under basal conditions and after restraint in conscious rats or after surgical stress under general anesthesia. Male Wistar rats were treated with 5 mg/kg/day candesartan in the drinking water for 2 weeks. The hypothalamic AMPK activity was determined under basal and stress conditions, using a kinase activity assay. Chronic administration of candesartan significantly increased hypothalamic AMPK activity. Hypothalamic AMPK activity was also increased by restraint stress whereas no change was observed during surgical stress under anesthesia. The high levels of hypothalamic AMPK activation observed in candesartan-treated rats were not changed by restraint stress but were reduced to control levels by anesthesia and surgery. In conclusion, chronic candesartan treatment and restraint stress in conscious rats stimulate the hypothalamic AMPK activity, whereas surgical stress under anesthesia inhibits pathways regulating the AMPK activity even in candesartan-treated rats. 相似文献
922.
Shannon R. Zentall Julia M. Braungart‐Rieker Naomi V. Ekas Diane M. Lickenbrock 《Infant and child development》2012,21(5):443-457
The development of sleep–wake regulation occurs within the context of the infant–parent relationship. The present study investigated (1) patterns of change in night waking across infancy and attachment to parents and (2) if dependency, a characteristic of secure subgroup B4 and insecure‐resistant infants, accounted for differences in night waking. Forty‐six families reported on the number of infant night wakings at 7, 12, and 14 months of age. Attachment was measured at 12 (infant–mother) and 14 (infant–father) months. Findings suggest that infants with a secure (including the dependent‐secure, B4) pattern of attachment with mothers decreased in the number of night wakings over time, whereas infants with an insecure‐resistant pattern of attachment with mothers continued to wake at night into the second year. Attachment dependency did not account for differences in night waking. These findings are important to understanding the mechanism(s) underlying the relation between attachment and sleep–wake regulation. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
923.
The aim of the present study was to determine how authenticity of emotion expression in speech modulates activity in the neuronal
substrates involved in emotion recognition. Within an fMRI paradigm, participants judged either the authenticity (authentic
or play acted) or emotional content (anger, fear, joy, or sadness) of recordings of spontaneous emotions and reenactments
by professional actors. When contrasting between task types, active judgment of authenticity, more than active judgment of
emotion, indicated potential involvement of the theory of mind (ToM) network (medial prefrontal cortex, temporoparietal cortex,
retrosplenium) as well as areas involved in working memory and decision making (BA 47). Subsequently, trials with authentic
recordings were contrasted with those of reenactments to determine the modulatory effects of authenticity. Authentic recordings
were found to enhance activity in part of the ToM network (medial prefrontal cortex). This effect of authenticity suggests
that individuals integrate recollections of their own experiences more for judgments involving authentic stimuli than for
those involving play-acted stimuli. The behavioral and functional results show that authenticity of emotional prosody is an
important property influencing human responses to such stimuli, with implications for studies using play-acted emotions. 相似文献
924.
White LO Wu J Borelli JL Rutherford HJ David DH Kim-Cohen J Mayes LC Crowley MJ 《Emotion (Washington, D.C.)》2012,12(4):690-700
Attachment representations are thought to provide a cognitive-affective template, guiding the way individuals interact with unfamiliar social partners. To examine the neural correlates of this process, we sampled event-related potentials (ERPs) during exclusion by unfamiliar peers to differentiate insecure-dismissing from securely attached youth, as indexed by the child attachment interview. Thirteen secure and 10 dismissing 11- to 15-year-olds were ostensibly connected with two peers via the Internet to play a computerized ball-toss game. Actually, peers were computer generated, first distributing the ball evenly, but eventually excluding participants. Afterward children rated their distress. As in previous studies, distress was related to a negative left frontal slow wave (500-900 ms) during rejection, a waveform implicated in negative appraisals and less approach motivation. Though attachment classifications were comparable in frontal ERPs and distress, an attachment-related dismissal dimension predicted a negative left frontal slow wave during rejection, suggesting that high dismissal potentially involves elevated anticipation of rejection. As expected, dismissal and self-reported distress were uncorrelated. Yet, a new approach to quantifying the dissociation between self-reports and rejection-related ERPs revealed that dismissal predicted underreporting of distress relative to ERPs. Our findings imply that evaluations and regulatory strategies linked to attachment generalize to distressing social contexts in early adolescence. 相似文献
925.
Schmierbach M Limperos AM Woolley JK 《Cyberpsychology, behavior and social networking》2012,15(7):364-369
Prior research suggests that video game features that appear natural or that otherwise allow players to identify with their in-game experience will promote enjoyment. Using a 2 × 2 experiment, this study demonstrates the positive effects of a steering-wheel controller and the opportunity to customize the driven vehicle on enjoyment of a console driving game, as mediated by transportation and challenge-skill balance. The role of presence is also probed, with results suggesting no direct link to enjoyment. 相似文献
926.
Adrian Furnham Julia Crawshaw Richard Rawles 《Journal of applied social psychology》2006,36(2):417-440
Two related studies investigated sex differences in self- and parental estimates of IQ scores on specific scales derived from standardized and validated IQ tests. In the first study 210 participants were asked to estimate their scores on the 11 WAIS-R subtests as well as their overall general IQ. Results showed males estimated their overall score, plus their total WAIS score, significantly higher than females, with effect sizes around 0.5. Factor analysis showed participants did differentiate between verbal and performance subscale scores on this test. In the second study 117 participants performed a similar task, but this time on the 12 subscales of the Stanford-Binet test. Males estimated their overall score higher than females. Factor analysis also showed 2 clear factors that reflected exactly the verbal and performance subscale scores. 相似文献
927.
Julia Buckroyd Sharon Rother David Stott 《British Journal of Guidance & Counselling》2006,34(2):245-265
The studies reported here explored whether therapeutic groups for women who eat compulsively can demonstrate weight loss as a primary result as well as the improvements in emotional functioning reported by other investigators. In both studies questionnaire data showed little change in self-esteem or attitudes as measured by the Rosenberg Self-Esteem and the Eating Disorders Examination. However, interview data showed considerable changes in attitudes and emotional functioning. The initial study demonstrated no weight loss but marked changes in participants’ attitudes to themselves and food, likely to lead to weight loss. A second, longer, uncontrolled study again showed changes in emotional functioning plus weight loss of 5% or more of initial body weight at the end of the intervention in 75% of participants who completed the study (n=8) or 50% of those who were initially recruited (n=12). Weight loss has been maintained in 75% of participants at 18-month follow-up. The data are based on a small sample, which can only be suggestive but supports a further study. 相似文献
928.
Julia Levashina Michael A. Campion 《International Journal of Selection & Assessment》2006,14(4):299-316
There has been surprisingly little research on faking in the employment interview, despite the fact that professional judgment would suggest that faking might occur in the interview. Based on a review of the literature on faking in personality tests and the literature on deception, we propose a model of faking during an employment interview and develop 19 testable propositions to guide future research. We argue that faking is a function of capacity, willingness, and opportunity to fake. Structured interviews provide less opportunity for intentional distortion; however, some components of structure may actually increase faking. Finally, job candidates distort their responses in job desirable ways. 相似文献
929.
Julia Fehniger Feng Lin Mary S. Beattie Galen Joseph Celia Kaplan 《Journal of genetic counseling》2013,22(5):603-612
Previous studies examining communication of BRCA1/2 results with relatives and family uptake of BRCA1/2 testing have sampled from predominantly white, high SES cohorts ascertained solely from tertiary care centers. No studies have focused on family communication and testing among relatives of diverse BRCA1/2 carriers. We conducted structured interviews with 73 BRCA1/2 carriers identified at a public hospital and a tertiary cancer center. We asked participants if each first- and second-degree relative was aware of their BRCA1/2 results and whether or not each relative had tested. Generalized estimating equations identified rates and predictors of family communication and testing. Participants disclosed their test results to 73 % of 606 eligible relatives and 31 % of 514 eligible relatives tested. Communication and testing rates were similar for relatives of participants from the public hospital and the tertiary cancer center. Hospital site was not a significant predictor of either result disclosure or relative uptake of testing. African American and Asian/Pacific Islander participants were significantly less likely to disclose their results to their relatives; relatives of African American participants were significantly less likely to test. Addressing these disparities will require further research into the best ways to facilitate family communication and counsel at-risk relatives of racially and socioeconomically diverse BRCA1/2 mutation carriers. 相似文献
930.
The present research examines the emotional and behavioral consequences of collective action participation. It demonstrates that "positive" and "negative" emotions can be experienced simultaneously as a result of collective action participation, yet it is important to distinguish outgroup-directed from self-directed emotions. Results of two experiments (N = 71 and N = 101) that manipulated participation in collective action illustrate that whereas collective action participants experience more outgroup-directed anger and contempt, they feel more self-directed positive affect. Furthermore, collective action participation predicted willingness to engage in moderate and radical collective actions in the future. These relations were mediated by outgroup-directed, but not by self-directed, emotions, suggesting that outgroup-directed rather than self-directed emotions play a crucial role in the maintenance of protest behavior. Theoretical and practical implications of these findings are discussed. 相似文献