Gender-moderated dorsolateral prefrontal reductions in 22q11.2 Deletion Syndrome: implications for risk for schizophrenia.

To investigate the impact of the microdeletion on morphology of the prefrontal cortex in 22q11.2 Deletion Syndrome (22q11.2 DS), high-resolution, anatomic magnetic resonance imaging was performed on 19 children and adolescents with 22q11.2 DS (11 females, 8 males) and 18 unaffected controls (10 females, 8 males). Tissue volumes of the dorsolateral, dorsomedial, orbitolateral, and orbitomedial prefrontal cortex were measured. Tasks of executive function and working memory were administered to investigate the association between anatomy and function. Whole brain volume and frontal lobe tissue volume were preserved in girls but reduced in boys with 22q11.2 DS relative to age-matched controls. Dorsolateral prefrontal cortex (DLPFC) volumes were reduced in participants with 22q11.2 DS, although the gender-by-diagnosis effect found for frontal lobe was not as robust for DLPFC. DLPFC volumes were associated with performance on tasks of planning and emotional facial recognition. Longitudinal studies are needed to clarify whether gender differences in frontal lobe and DLPFC persist with development, and whether the volumes of the DLPFC are associated with eventual deterioration in adaptive/psychosocial function that may presage the onset of schizophrenia, for which individuals with 22q11.2 DS are at a disproportionately high risk.     

Aging selectively impairs recollection in recognition memory for pictures: evidence from modeling and receiver operating characteristic curves

Young and older adults were tested on recognition memory for pictures. The Yonelinas high threshold (YHT) model, a formal implementation of 2-process theory, fit the response distribution data of both young and older adults significantly better than a normal unequal variance signal-detection model. Consistent with this finding, nonlinear z-transformed receiver operating characteristic curves were obtained for both groups. Estimates of recollection from the YHT model were significantly higher for young than for older adults. This deficit was not a consequence of a general decline in memory; older adults showed comparable overall accuracy and in fact a nonsignificant increase in their familiarity scores. Implications of these results for theories of recognition memory and the mnemonic deficit associated with aging are discussed.     

Ekstasis as (Beyond?) Jouissance: Sex,Queerness, and Apophaticism in the Eastern Orthodox Tradition

Ekstasis (ecstasy) is central to Eastern Orthodox theology, an encounter that sets the self on the way towards knowledge of and union with God. Ekstasis is fundamentally apophatic — achieved through the eschewal of cognitive knowledge, and experiential — precipitated by practices that foster self-renunciation and transcendence. This article examines how this notion of ecstasy, as narrated in the Orthodox theology of Staniloae and Lossky, can aid, and be aided by, queer theoretical claims regarding sex. Through examining Lacan's notion of jouissance and Bersani's utilization of it, as well as Williams's analysis of sex as “the body's grace,” this article explores how sex, particularly orgasm, can function as a spiritual resource, as a site of and practice towards ecstasy. This article concludes with a brief examination of the ethical implications of this frame.     

Caution or Warning? A Validity Study of the MAYSI‐2 with Juvenile Offenders

Given the high prevalence of mental health and substance use disorders in the juvenile justice system and the emphasis on efficient screening and referrals, the current study sought to further validate the use of the Massachusetts Youth Screening Instrument version 2 (MAYSI‐2). Using data from institutionalized delinquents (N = 836) committed to the California Youth Authority, finite mixture modeling was employed to identify distinct latent classes based on MAYSI‐2 scale scores. Identified classes were then compared across a range of covariates, including prior offenses, official records of misconduct, and multiple measures of mental health and psychological well‐being. Findings revealed a three‐class, gradient‐based structure: low distress (n = 380), moderate distress (n = 327), and high distress (n = 129). Overall, the MAYSI‐2 identified juvenile offenders with mental health and substance use issues, but it did not differentiate youths with respect to offending patterns. Copyright © 2014 John Wiley & Sons, Ltd.     

Cultural and Cognitive Predictors of Academic Motivation Among Mexican American Adolescents: Caution Against Discounting the Impact of Cultural Processes

This study examined the role of cognitive (i.e., grit, hope, and academic skepticism) and cultural variables (i.e., generational status, familismo, ethnic identity, and bicultural stress) on academic motivation among 181 Mexican American adolescents. Results indicated that hope, grit, and familismo positively predicted academic motivation. Conversely, academic skepticism and bicultural stress negatively predicted academic motivation. This study demonstrates that culture is important to consider above and beyond cognitive variables. Implications for practice and research are discussed. Este estudio examinó la influencia que ejercen las variables cognitivas (determinación, esperanza y escepticismo académico) y culturales (estatus generacional, familismo, identidad étnica y estrés bicultural) sobre la motivación académica en 181 adolescentes mexicano‐americanos. Los resultados indicaron que la esperanza, la determinación y el familismo pronosticaron positivamente la motivación académica. Y a la inversa, el escepticismo académico y el estrés bicultural pronosticaron negativamente la motivación académica. Este estudio demuestra que es importante considerar la cultura además de las variables cognitivas. Se discuten las implicaciones para la práctica y la investigación.