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71.
The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice 下载免费PDF全文
Using pharmacological techniques, it has been demonstrated that both consolidation and extinction of Pavlovian fear conditioning are dependent to some extent upon L-type voltage-gated calcium channels (LVGCCs). Although these studies have successfully implicated LVGCCs in Pavlovian fear conditioning, they do not provide information about the specific LVGCC isoform involved. Both of the major LVGCC subtypes found in the brain (Cav1.2 and Cav1.3) are targets of the pharmacological manipulations used in earlier work. In this study, we used mice in which the gene for the pore-forming subunit (alpha1D) Cav1.3 was deleted (Cav1.3 knockout mice) to elucidate its contribution to consolidation and extinction of conditioned fear. We find that Cav1.3 knockout mice exhibit significant impairments in consolidation of contextual fear conditioning. However, once sufficiently overtrained, the Cav1.3 knockout mice exhibit rates of extinction that are identical to that observed in wild-type mice. We also find that Cav1.3 knockout mice perform as well as wild-type mice on the hidden platform version of the Morris water maze, suggesting that the consolidation deficit in conditioned fear observed in the Cav1.3 knockout mice is not likely the result of an inability to encode the context, but may reflect an inability to make the association between the context and the unconditioned stimulus. 相似文献
72.
The reliability and validity of the Self-Report Psychopathy Scale (SRPS) was examined in a noninstitutionalized offender sample of mixed gender and race. Adequate alpha coefficients were obtained for the total sample and across gender and race. The SRPS was compared to measures of trait anxiety and passive avoidance errors. SRPS total, primary, and secondary scores were positively and significantly correlated with trait anxiety and passive avoidance (commission) errors, but not omission errors. Employing hierarchical regression models, no anxiety, gender, or ethnic effects were found. Intelligence confounded the relationship between psychopathic traits and passive avoidance errors. Findings provide tentative support of the SRPS as a valid measure of psychopathy. 相似文献
73.
Chambers DA Pearson JL Lubell K Brandon S O'brien K Zinn J 《Suicide & life-threatening behavior》2005,35(2):134-145
There is minimal guidance for efforts to create effective public messages that increase awareness that suicide is preventable. To address this need, several agencies in the U.S. Department of Health and Human Services and the Annenberg Foundation convened a workshop consisting of suicide prevention advocates and persons with expertise in public health evaluation, suicide contagion, decision-making, and marketing. "Logic models" were used to define intended messages and audiences, assumed mechanisms of change, and outcomes. This summary describes some of the challenges and opportunities identified by workshop participants in evaluating public awareness campaigns in suicide prevention, technical assistance needs, and a proposed research agenda. 相似文献
74.
75.
Matthew J. Sharps Brandon T. Foster Sandy S. Martin Michael A. Nunes 《Current psychology (New Brunswick, N.J.)》1999,18(3):241-253
Previous studies have demonstrated that older adults can use visually distinctive cues to enhance their spatial memory performance
and their recall of the identities of items located in space. Other research has shown that older adults can also use relational
information to enhance recall. The relationship between relational and visuospatial support for memory across the adult lifespan
is complex and has been little explored. In the present study, this relationship was examined in tasks that measured free
recall for item sets possessing different degrees of visuospatial and relational support for recall. It was predicted that
both types of support would enhance older adult recall relative to that of the young, and that the two types of support would
synergize. The results were generally consistent with these predictions. These findings show that older adults can use relatively
simple relational or visuospatial support systems to enhance free recall significantly.
This research was supported by Grant AGI 1605, National Institute on Aging. 相似文献
76.
An intervention for noncompliance consisting of a series of requests promoting a high probability of compliance followed either 5 s or 20 s later by a request with a low probability of compliance was implemented with a preschool child with autism. Results indicated that applications of the request sequence with a shorter interprompt time resulted in higher rates of compliance, and longer interprompt times resulted in near-baseline rates of compliance. 相似文献
77.
Theory and experiment in evolutionary biology 总被引:1,自引:0,他引:1
Robert N. Brandon 《Synthese》1994,99(1):59-73
78.
J C Bombace S E Brandon A R Wagner 《Journal of experimental psychology. Animal behavior processes》1991,17(3):323-333
Two experiments with rabbits showed that the differential modulation of a conditioned eyeblink response (CR) by 30-s auditory stimuli previously paired with shock was independent of the locus of shock application. In Experiment 1, the modulation occurred when the CR was trained with paraorbital shock and the 30-s stimuli were trained with either hindleg or paraorbital shock. Experiment 2 replicated the observed adequacy of hindleg shock for modulation training, under 2 different conditions of eyeblink conditioning. The data, along with the findings that the same 30-s stimuli similarly facilitate the unconditioned eyeblink and the airpuff-elicited startle response (Brandon, Bombace, Falls & Wagner, 1991), were viewed as supporting the notion that the CR-modulation is dependent upon a conditioned fear response elicited by the 30-s cues (Wagner & Brandon, 1989). 相似文献
79.
Brandon Hogan 《The Southern journal of philosophy》2023,61(1):82-111
In the Philosophy of Right, Hegel claims that crime is a negation of right and punishment is the “negation of the negation.” Punishment, for Hegel, “annuls” the criminal act. Many take it that Hegel endorses a form of retributivism—the theory that criminal offenders should be subject to harsh treatment in response and in proportion to their wrongdoing. Here I argue that restorative criminal justice is consistent with Hegel's remarks on punishment and his overall philosophical system. This is true, in part, because restorative justice integrates Hegel's instructive discussion of confession and forgiveness in the Phenomenology of Spirit. Hegel claims that true moral relationships allow space for persons to confess their moral shortcomings and forgive the shortcomings of others. Restorative criminal justice brings the perpetrators and victims of crime together to offer confessions and forgiveness and to work to heal the various wounds caused by crime. I do not claim that Hegel must be read as advocating restorative justice. While Hegel tells us what punishment does, he does not commit himself to any form of punishment. What I offer here is a rational, progressive reconstruction and extension of Hegel's conception of crime and punishment. 相似文献
80.
Brandon C. Perez Janelle K. Bacotti Kerri P. Peters Timothy R. Vollmer 《Journal of applied behavior analysis》2020,53(4):2360-2375
The current study evaluated a toilet-training treatment package described by Greer et al. (2016) with children diagnosed with autism spectrum disorder (ASD). Most of the current research on toilet-training interventions for children with ASD are replications and modifications of Azrin and Foxx (1971) or (more recently) LeBlanc et al. (2005). However, these procedures are composed of components that are not included in studies with typically developing (TD) children. For example, Greer et al. evaluated the effectiveness of three typical components within a toilet-training package, mostly with TD participants: a 30-min sit schedule, placing participants in underwear, and differential reinforcement. The primary purpose of the current study was to replicate and extend the treatment package described by Greer et al. to children with ASD. A secondary purpose was to evaluate modifications necessary for individualized toilet training when the commonly used components were ineffective. The results of Greer et al. were replicated for 11 participants with ASD in the current study, suggesting that intensive toileting interventions (e.g., interventions requiring overcorrection, reprimands, and dense sit schedules) may only be necessary for a subset of individuals with ASD. 相似文献