An acquired deficit of audiovisual speech processing

We report a 53-year-old patient (AWF) who has an acquired deficit of audiovisual speech integration, characterized by a perceived temporal mismatch between speech sounds and the sight of moving lips. AWF was less accurate on an auditory digit span task with vision of a speaker's face as compared to a condition in which no visual information from the lower face was available. He was slower in matching words to pictures when he saw congruent lip movements compared to no lip movements or non-speech lip movements. Unlike normal controls, he showed no McGurk effect. We propose that multisensory binding of audiovisual language cues can be selectively disrupted.     

Acute and chronic effects of cocaine on the spontaneous behavior of pigeons

The present experiment examined the effects of acute and daily cocaine on spontaneous behavior patterns of pigeons. After determining the acute effects of a range of doses, 9 pigeons were divided into three groups that received one of three doses of cocaine daily, either 1.0, 3.0, or 10.0 mg/kg cocaine. Measures were taken of spontaneous locomotion, pecking, preening, and emesis. Under daily administration, cocaine induced consistent and substantial enhancements of its locomotor effects in all 9 pigeons, consistent with the phenomenon of locomotor sensitization. The maximum locomotor output did not differ according to the size of the daily dose. Locomotion was not elevated following tests of the saline vehicle, suggesting the effect was due to cocaine, not to a change in baseline or reactivity to the injection procedure. Cocaine dose‐dependently decreased preening when given acutely, and those effects were not altered by repeated cocaine administration. Pecking occurred at very low rates and was unresponsive to cocaine treatment. Cocaine‐induced emesis showed a dose‐dependent increase under initial tests with cocaine, and those effects were attenuated following daily exposure. In a final condition, cocaine was replaced with daily saline for 30 days to assess the persistence cocaine‐related increases in locomotion. Approximately half of the pigeons continued to show enhanced effects even after 30 days without cocaine, so although persistence was obtained, it showed marked intersubject variability. The data indicate that the effects of repeated cocaine administration on the behavior of pigeons shows parallels with many effects commonly reported with rodents (i.e., increased locomotion following repeated treatment, decrease in preening or grooming, persistence following drug withdrawal).     

Empirical validation of a procedure to correct position and stimulus biases in matching-to-sample

The development of position and stimulus biases often occurs during initial training on matching-to-sample tasks. Furthermore, without intervention, these biases can be maintained via intermittent reinforcement provided by matching-to-sample contingencies. The present study evaluated the effectiveness of a correction procedure designed to eliminate both position and stimulus biases. Following key-peck training, a group of 6 pigeons had extended exposure to matching-to-sample contingencies without a correction procedure, a group of 4 pigeons was briefly exposed to a simultaneous matching-to-sample procedure to assess biases prior to exposure to the correction procedure, and a group of 5 pigeons was exposed directly to the correction procedure. The correction procedure arranged that every time an incorrect match was made, the trial configuration was repeated on the subsequent trial until a correct match was made. Extended exposure to matching-to-sample contingencies without a correction procedure was associated with reduced biases eventually for most subjects, but rapid development of near-perfect accuracy and bias-free performance was observed upon the implementation of the correction procedure regardless of the type of bias. Bias-free performance was maintained following subsequent exposure to a zero-delay MTS procedure.     

Dissociations of writing and praxis: Two cases in point

For normal writing it is essential that both motoric and linguistic competence be present; disruption of one or the other of these faculties may result in qualitatively different types of agraphia. Two right-handed patients became agraphic after left hemisphere lesions; pure apraxic agraphia in the absence of limb apraxia developed in one patient and pure linguistic agraphia in association with severe ideomotor limb apraxia in the other. The performance of these patients not only serves to illustrate the dissociation between the motoric and linguistic faculties that underlie writing but also confirms that ideomotor limb apraxia and apraxic agraphia are distinct and dissociable entities.     

Key pecking of pigeons under variable-interval schedules of briefly signaled delayed reinforcement: effects of variable-interval value.

Key pecking of 4 pigeons was maintained under a multiple variable-interval 20-s variable-interval 120-s schedule of food reinforcement. When rates of key pecking were stable, a 5-s unsignaled, nonresetting delay to reinforcement separated the first peck after an interval elapsed from reinforcement in both components. Rates of pecking decreased substantially in both components. When rates were stable, the situation was changed such that the peck that began the 5-s delay also changed the color of the keylight for 0.5 s (i.e., the delay was briefly signaled). Rates increased to near-immediate reinforcement levels. In subsequent conditions, delays of 10 and 20 s, still briefly signaled, were tested. Although rates of key pecking during the component with the variable-interval 120-s schedule did not change appreciably across conditions, rates during the variable-interval 20-s component decreased greatly in 1 pigeon at the 10-s delay and decreased in all pigeons at the 20-s delay. In a control condition, the variable-interval 20-s schedule with 20-s delays was changed to a variable-interval 35-s schedule with 5-s delays, thus equating nominal rates of reinforcement. Rates of pecking increased to baseline levels. Rates of pecking, then, depended on the value of the briefly signaled delay relative to the programmed interfood times, rather than on the absolute delay value. These results are discussed in terms of similar findings in the literature on conditioned reinforcement, delayed matching to sample, and classical conditioning.     

Observing responses in pigeons: effects of schedule component duration and schedule value

Pigeons were exposed to a procedure under which five pecks on one response key (the observing key) changed the schedule on a second key (the food key) from a mixed schedule to a multiple schedule for 25 sec. In Experiment I, a random-ratio 50 schedule alternated with extinction. The duration of the random-ratio 50 schedule component was varied between 1.25 and 320 sec, and extinction was scheduled for a varying time, ranging from the duration of the random-ratio 50 to four times that value. Each set of values was scheduled for a block of sessions. Before observing-key pecks were allowed at each set of parameter values, the pigeons were exposed to a condition where the mixed and multiple schedule alternated every 10 min, and observing-key pecks were not permitted. Rates of pecking on the observing key were high for all values of random-ratio component durations except 1.25 sec. Experiment II was conducted with the random-ratio component duration equal to 40 sec, and the random-ratio schedule was varied from random-ratio 50 to 100, 200, and 400. Observing-key pecking rates were high for all values of the random-ratio schedule except random-ratio 400. In both experiments, observing response rates were relatively little affected, suggesting that neither schedule component duration nor schedule value is a strong determinant of observing responses.     

Effects of cocaine on performance under fixed-interval schedules with a small tandem ratio requirement

Daily administration of cocaine often results in the development of tolerance to its effects on responding maintained by fixed-ratio schedules. Such effects have been observed to be greater when the ratio value is small, whereas less or no tolerance has been observed at large ratio values. Similar schedule-parameter-dependent tolerance, however, has not been observed with fixed-interval schedules arranging comparable interreinforcement intervals. This experiment examined the possibility that differences in rate and temporal patterning between the two types of schedule are responsible for the differences in observed patterns of tolerance. Five pigeons were trained to key peck on a three-component multiple (tandem fixed-interval fixed-ratio) schedule. The interval values were 10, 30, and 120 s; the tandem ratio was held constant at five responses. Performance appeared more like that observed under fixed-ratio schedules than fixed-interval schedules. Effects of various doses of cocaine given weekly were then determined for each pigeon. A dose that reduced responding was administered prior to each session for 50 days. A reassessment of effects of the range of doses revealed tolerance. The degree of tolerance was similar across components of the multiple schedule. Next, the saline vehicle was administered prior to each session for 50 days to assess the persistence of tolerance. Tolerance diminished in all subjects. Overall, the results suggested that schedule-parameter-dependent tolerance does not depend on the temporal pattern of responding engendered by fixed-ratio schedules.     

Tolerance to cocaine's rate-increasing effects upon repeated administration.

Four squirrel monkeys responded daily under a fixed-interval 5-min or 8-min schedule of food-pellet delivery. Cocaine (0.03 to 1.7 mg/kg) and saline were injected before occasional daily sessions (acute administration). Some doses of cocaine produced substantial overall increases in response rate for 3 of the subjects; effects were less substantial for the remaining subject, who exhibited modest increases in response rate early in the session and during the middle portion of the intervals. A dose that increased response rate when administered acutely was then administered before each session (chronic administration). Chronic administration resulted in a reduction in the increases in response rate seen under acute administration for all subjects.