Relative novelty of conditioning context influences directionality of glycemic conditioning

Previous experiments in which insulin was administered in a Pavlovian conditioning procedure obtained both hyperglycemic and hypoglycemic conditioned responses (CRs). In the present experiment the relationship of the conditioning context and the housing environment was varied. Two environments, wastebasket (WB) and metal cage (MC), were varied factorially as housing and conditioning contexts. Subgroups were injected with either insulin or saline for 6 days and then, on a test day for conditioning, all animals were administered saline. The results suggested that a hyperglycemic CR could be expected when the conditioning context is different from the housing context, but a hypoglycemic CR could be expected when the conditioning context and housing context are similar. The magnitude and reliability of conditioning were greater when it was conducted in the WB context than when conditioning was conducted in the MC context. These results are discussed in terms of stress arising from relative novelty of the conditioning environment and in terms of the salience of the conditioned stimulus (CS) used in glycemic conditioning studies.     

Monozygotic twins with schizoform psychosis and hypothalamic-induced hypogonadotropic hypogonadism

It is reported about an uniovular male pair of twins which has been permanently hospitalized because of an intermittently progressing schizoform psychosis. A hypothalamically conditioned hypogonadotropic hypogonadism provable beyond that substantiates the possibility of the common causal genetic embodiment of both the clinical pictures which is disputed in literature.     

Factor and ideal point analysis for interpersonally incomparable data

Interpersonally incomparable responses pose a significant problem for survey researchers. If the manifest responses of individuals differ from their underlying true responses by monotonic transformations which vary from person to person, then the covariances of the manifest responses tools such as factor analysis may yield incorrect results. Satisfactory results for interpersonally incomparable ordinal responses can be obtained by assuming that rankings are based upon a set of multivariate normal latent variables which satisfy the factor or ideal point models of choice. Two statistical methods based upon these assumptions are described; their statistical properties are explored; and their computational feasibility is demonstrated in some simulations. We conclude that is possible to develop methods for factor and ideal point analysis of interpersonally incomparable ordinal data.This research was begun in the supportive enviroment of the Survey Research Center at the University of California, Berkeley. Financial support was provided by Percy Tannenbaum, Director of the Center, by Allan Sindler, Dean of the Graduate School of Public Policy at Berkeley, by the Data Center of Harvard University, and by the National Science Foundation through grant number SES-84-03056. Chris Achen, Doug Rivers, and members of the Harvard-MIT econometrics seminar provided useful comments.     

Differential preparatory cardiovascular responses to aversive and appetitive behavioral conditioning

Dogs were required to press a response panel either to avoid shock or obtain food. During a one-hour interval immediatelypreceding performance on the avoidance task, blood pressure increased while heart rate decreased. In contrast, both blood pressure and heart rate increased during the one-hour interval immediatelypreceding performance on the food task. During both the shock-avoidance and food performancesper se, however, elevations in heart rate and blood pressure were observed, though the avoidance task produced less consistent heart rate changes. These effects were observed (1) with different individual dogs on each of the two training procedures, and (2) with the same dogs exposed successively to both aversive and appetitive behavioral conditioning.     

Instrumental conditioning of blood pressure elevations in the baboon

Two adult male baboons were surgically prepared with arterial catheters which provided a continuous measure of blood pressure and heart rate. Environmental consequences (food and electric shock) were made contingent upon prespecified increases in diastolic blood pressure levels. Continued exposure to these contingencies resulted in substantial increases in both diastolic and systolic pressures. The results demonstrated that blood pressure changes are highly susceptible to both operant“shaping” and stimulus control procedures and extend the range of instrumental conditioning effects upon the cardiovascular system.     

Cardiovascular dynamics during classical appetitive and aversive conditioning in laboratory primates

This report describes changes in the rate of rise of left and right intraventricular pressures during aversive and appetitive conditioning procedures in chair-restrained rhesus monkeys. The conditioning paradigm consisted of a one-minute tone followed, in the one case, by an electric shock, and in the other, by the delivery of Purina monkey pellets. The conditional cardiovascular response was characterized by short latency, highly significant elevations in the derivatives of both ventricular pressures as well as a marked arterial pressor response and tachycardia. The magnitude of the conditional response to the classical aversive procedure was somewhat larger than that to appetitive conditioning. These alterations in the rate of development of intraventricular pressure can be attributed largely to augmentation in the sympathetic neural input to the heart and contribute to an analysis of selective aspects of the nervous regulation of the heart in intact, behaviorally conditioned animals.     

Operant acceleration during a pre-reward stimulus

Stimuli of 20, 40, and 80 sec duration terminated with five non-response-contingent food pellets were superimposed upon lever pressing reinforced with single pellets on a DRL 30-sec schedule. Two rhesus monkeys served as subjects. No change in response frequency was observed during the 20- and 40-sec stimuli. During the 80-sec pre-food stimulus, overall response frequency increased to approximately 150% and 220% of pre-stimulus levels, and the temporal distributions of interresponse times shifted toward the shorter intervals. When the 80-sec stimulus was no longer terminated with food, the response frequency decreased and the temporal distributions of interresponse times gradually approached pre-stimulus levels. An increased frequency of short interresponse times and an increase in response rate was again observed when the pellet termination procedure was reinstituted with the 80-sec stimulus. No change in response frequency or interresponse times was observed in the absence of the conditioning stimulus, and performance efficiency, as reflected in the ratio of responses to reinforcements during non-stimulus periods, remained stable throughout the experiment.