Illness perception in people with chronic obstructive pulmonary disease

Illness perception (IP) concerns how patients evaluate living with a disease. To get a broader understanding of IP in patients with chronic obstructive pulmonary disease (COPD), we investigated whether breathlessness is an important precursor of IP and whether IP in its turn is related to mental health, physical health and global quality of life (QOL). One hundred and fifty‐four patients with COPD participated in a cross‐sectional survey. Participants underwent pulmonary function testing, provided socio‐demographic and clinical information, and completed the following standardized instruments: Brief Illness Perception Questionnaire, Respiratory Quality of Life Questionnaire, Short‐Form 12 Health Survey and the Quality of Life Scale. Multiple regression analyses were performed. A high IP score indicates that a patient believes that his/her illness represents a threat. Participants with a high score on the IP dimensions consequences, identity, concern and emotional representation, experienced more breathlessness. High scores on the IP dimensions consequences, identity and concern were associated with impaired physical health and high scores on the IP dimensions consequences, identity and emotional representation were associated with impaired mental health. Impaired global QOL was associated with high scores on the IP dimensions consequences, identity, concern, coherence and emotional representation. The strength of the associations between breathlessness and physical/mental health and global QOL decreased when certain dimensions of IP were included as predictors, indicating that IP to some extent acts as a mediating factor. These findings may have practical implications of patient counselling by helping COPD patients to cope with their disease by restructuring their personal models of illness.     

Impassibility and revelation

What is the relation between divine unchangeability and the reality of change as implied in ideas of creation and redemption? Western Trinitarian theology in the 20^th century tended toward emphasizing the significance of change above divine unchangeability, giving it a modalist and Hegelian flavour that questioned the continuity with the church fathers. For this reason, it has been criticized by Orthodox theologians like Vladimir Lossky and David Bentley Hart. Newer scholarship has shown the significance of Luther's appropriation of the doctrine of divine unknowability and his insistence on the difference between revelation and divine essence for his understanding of the Trinity, which thus may appear to be much closer to the position of the Orthodox critics than to the Lutheran theologians criticized by them. There thus seems to be an unused potential in Luther's doctrine of the Trinity that should be of interest both for systematic and ecumenical theology.     

Right-sided human prefrontal brain activation during acquisition of conditioned fear

This H2(15)O positron emission tomography (PET) study reports on relative regional cerebral blood flow (rCBF) alterations during fear conditioning in humans. In the PET scanner, subjects viewed a TV screen with either visual white noise or snake videotapes displayed alone, then with electric shocks, followed by final presentations of white noise and snakes. Autonomic nervous system responses confirmed fear conditioning only to snakes. To reveal neural activation during acquisition, while equating sensory stimulation, scans during snakes with shocks and white noise alone were contrasted against white noise with shocks and snakes alone. During acquisition, rCBF increased in the right medial frontal gyrus, supporting a role for the prefrontal cortex in fear conditioning to unmasked evolutionary fear-relevant stimuli.     

M. Parkinson: L-Dopa nach wie vor wirksamste Therapie

More than 50 years after its introduction into clinical practice, L?dopa still is the most effective therapy for Parkinson’s disease and the gold standard for all other medications. In this article, two case reports are used to illustrate the good clinical efficacy and also the long-term complications of L?dopa therapy. The cause for these problems are the pharmacokinetics of L?dopa in combination with the progressive loss of nigrostriatal dopaminergic neurons in the course of the disease. New formulations of L?dopa offer hope for the improvement of these complications. One of these will soon be available for clinical use, while others are being tested in ongoing clinical trials.     

Enhanced encoding of the co-actor's target stimuli during a shared non-motor task

Task co-representation has been proposed to rely on the motor brain areas’ capacity to represent others’ action plans similarly to one's own. The joint memory (JM) effect suggests that working in parallel with others influences the depth of incidental encoding: Other-relevant items are better encoded than non-task-relevant items. Using this paradigm, we investigated whether task co-representation could also emerge for non-motor tasks. In Experiment 1, we found enhanced recall performance to stimuli relevant to the co-actor also when the participants’ task required non-motor responses (counting the target words) instead of key-presses. This suggests that the JM effect did not depend on simulating the co-actor's motor responses. In Experiment 2, direct visual access to the co-actor and his actions was found to be unnecessary to evoke the JM effect in case of the non-motor, but not in case of the motor task. Prior knowledge of the co-actor's target category is sufficient to evoke deeper incidental encoding. Overall, these findings indicate that the capacity of task co-representation extends beyond the realm of motor tasks: Simulating the other's motor actions is not necessary in this process.