Protein-binding assays for adrenocorticoids

The measurement of the adrenocortical hormones, Cortisol and corticosterone, m blood plasma has previously best been done by procedures employing varying degrees of purification of the hormone, followed by photometric or fluorimetric quantitation. These methods have been relatively difficult or laborious, particularly in the case of the procedures that most specifically measure the hormoneof intent. These limitations are considerably overcome by new assays for Cortisol and corticosterone based on the principle of competitive protein-binding of the steroids in the presence of radioactively labeled steroid of the same molecular species. These methods are described and data on the specificity of such a method for corticosterone are presented and compared with one of the better fluorimetric assays.     

Similarity of encoding context does not influence resistance to memory impairment following misinformation

Several recent studies have shown that exposure to verbal misleading post-event information does not impair subjects' ability to retrieve originally seen details. Two experiments were conducted to test the hypothesis that subjects would be more susceptible to memory impairment if the original and misleading information were presented in similar contextual formats. The results showed that misleading information did not lead to memory impairment when both original and misleading information were presented in the context of slides (Experiment 1) or when both original and misleading information were presented in the context of narratives (Experiment 2). Furthermore, resistance to memory impairment was observed both at relatively low levels of memory for the original information (Experiment 1) and at relatively high levels of memory for the original information (Experiment 2). The implications of the present results for interference principles of forgetting are discussed.     

The development of responses to people and a toy in infants with down syndrome

The behavior of eight infants with Down syndrome was observed biweekly from 8 to 24 weeks and monthly up to 48 weeks. At each visit the infants were presented with their mother, a female stranger, and a rattle puppet that were alternately active and passive. Each condition lasted 60 s. The results showed that by 4 months of age the infants began to differentiate, in the proportion of time they looked, smiled, and vocalized, between people and the toy. They did not discriminate, however, between mother and female stranger and between the active and passive adults until the second half of the first year. In particular, whereas normal infants usually show distress toward passive or “still-face” adults, the infants in this study continued to vocalize, at times even with smiling faces. The implications of these atypical aspects of the social development of infants with Down syndrome for their subsequent nonverbal communicative development are discussed.     

EINSTEIN AND MYSTICISM

Albert Einstein deliberately and repeatedly expressed his general religious views. But what were his views of mysticism? His statements on the subject were few, relatively obscure, and often misunderstood. A coherent answer requires setting those statements in historical, cultural, and theological context, as well as examining Einstein's philosophical and religious views. Though the Einstein that emerges clearly rejected supernatural mysticism, his views of “essential” mysticism were—though largely implicit—more nuanced, more subtle, and ultimately more sympathetic than “mere appearance” suggests.