多发性骨髓瘤的分子生物学特性及靶向治疗对策

近十年来,关于骨髓瘤细胞的分子生物学研究取得了很大的进展.骨髓瘤细胞通过激活多种信号途径以及与蛋白折叠反应相关的信号通路,抑制正常浆细胞的生长.一些基因和分子改变与临床表现相关并成为治疗的潜在靶点.认识骨髓瘤细胞的分子生物学特性对于采取合理的治疗措施、改善患者的预后至关重要.     

Different attitudes toward humor between Chinese and American students: evidence from the Implicit Association Test

Although cross-cultural research indicates that Chinese people demonstrate less humor than do Americans, little research addresses the reasons. This cross-cultural difference may be largely due to different implicit attitudes toward humor held by Chinese and Americans, deeply rooted in the two cultural traditions. Both self-report evaluation and the Implicit Association Test (IAT) were used to compare Chinese and American attitudes toward humor. Although 60 Chinese undergraduate students showed no significant difference from 33 American exchange students in explicit attitudes toward humor, the former associated humor more frequently with unpleasant adjectives and seriousness with pleasant adjectives on the IAT; the opposite pattern was found for the American group. This indicated a negative implicit attitude toward humor among the Chinese students.     

Development and Evaluation of a Decision Aid for BRCA Carriers with Breast Cancer

BRCA+ breast cancer patients face high risk for a second breast cancer and ovarian cancer. Helping these women decide among risk-reducing options requires effectively conveying complex, emotionally-laden, information. To support their decision-making needs, we developed a web-based decision aid (DA) as an adjunct to genetic counseling. Phase 1 used focus groups to determine decision-making needs. These findings and the Ottawa Decision Support Framework guided the DA development. Phase 2 involved nine focus groups of four stakeholder types (BRCA+ breast cancer patients, breast cancer advocates, and genetics and oncology professionals) to evaluate the DA's decision-making utility, information content, visual display, and implementation. Overall, feedback was very favorable about the DA, especially a values and preferences ranking-exercise and an output page displaying personalized responses. Stakeholders were divided as to whether the DA should be offered at-home versus only in a clinical setting. This well-received DA will be further tested to determine accessibility and effectiveness.     

Motivational incentives modulate age differences in visual perception

This study examined whether motivational incentives modulate age-related perceptual deficits. Younger and older adults performed a perceptual discrimination task in which bicolored stimuli had to be classified according to their dominating color. The valent color was associated with either a positive or negative payoff, whereas the neutral color was not associated with a payoff. Effects of incentives on perceptual efficiency and response bias were estimated using the diffusion model (Ratcliff, 1978). Perception of neutral stimuli showed age-related decline, whereas perception of valent stimuli, both positive and negative, showed no age difference. This finding is interpreted in terms of preserved top-down control over the allocation of perceptual processing resources in healthy aging.     

Chronic exposure to violent video games is not associated with alterations of emotional memory

Although acute effects of violent video game (VVG) exposure on affect and behaviour have been studied extensively, less is known about VVG effects on cognition. The present study examined whether chronic exposure to VVGs was associated with alterations in emotional long‐term memory. Participants completed an old‐new recognition task with 300 pictures of scenes ranging in emotion (negative, neutral and positive). We analysed accuracy and reaction time data using diffusion modelling to test a desensitization hypothesis. According to this hypothesis, VVG players would show reduced memory or a less liberal response bias for negative stimuli, compared with nonplayers. Contrary to the desensitization hypothesis, VVG exposure was not associated with differences in memory or response bias. This result suggests that, unlike other cognitive domains, long‐term memory may be robust to deleterious influences of chronic VVG exposure. Copyright © 2010 John Wiley & Sons, Ltd.     

From autonomy to creativity: a multilevel investigation of the mediating role of harmonious passion

Building on self-determination theory, we theorized about and demonstrated, through 2 multilevel field studies, the pivotal role of harmonious passion in translating organizational autonomy support and individual autonomy orientation into job creativity. Results based on 3-level data from 856 members in 111 teams within 23 work units of a porous metal company (Study 1) and from 525 employees in 98 teams of 18 branches of a large commercial bank (Study 2) revealed 2 major findings. First, organizational autonomy support from a higher organizational level (unit or branch) compensated for the effect of autonomy support from a lower organizational level (team) or individual autonomy orientation on employees' harmonious passion. Second, harmonious passion mediated the interactive effects of unit (branch) autonomy support and team member autonomy orientation, of team autonomy support and team member autonomy orientation, and of unit (branch) autonomy support and team autonomy support on individual creativity. We discuss the theoretical and practical implications of these findings in the organizational context.     

父母教养方式对子女焦虑的影响：认知情绪调节策略与男性化特质的中介作用

本研究通过对269名在校大学生进行父母教养方式、情绪调节策略的使用、男性化特质和焦虑水平的测查,探讨了父母教养方式对子女焦虑产生影响的可能机制。结果发现,研究建构的模型对焦虑的整体解释率为26%。父母教养方式主要通过三种途径影响子女焦虑：（1）直接对子女焦虑产生影响;（2）以灾难化和积极重评这两种情绪调节策略为中介,间接影响子女焦虑;（3）促成子女男性化特质的形成,该特质通过积极重评策略的完全中介作用,间接影响子女焦虑。     

《法苑珠林校注》补正

唐释道世撰写的《法苑珠林》,是一部重要的佛教类书,保留了极其丰富的佛教资料。中华书局2003年12月出版的由周叔迦与其弟子苏晋仁整理而成的《法苑珠林校注》,是目前《法苑珠林》最好的校注本。然因该书卷帙浩繁,有些校点可再商榷。此选取30例略加考辨,以就正于方家。     

论正确认识和处理宗教经济与经济宗教的关系

现阶段,随着我国宗教经济和经济宗教活动的日益活跃,如何正确认识和处理宗教经济和经济宗教二者的关系问题被突出地摆在党和人民的面前。依法管理宗教经济和以经济手段解决经济宗教中存在的问题是我们的必然选择。     

汉语儿童英语口语发展及口语任务的影响作用

本研究选取小学二、四、六年级共96名学生,通过自我介绍、被试主动发问、看图说话和角色扮演四种任务对其英语口语产出的流利性、精确性和复杂性进行了测查,研究结果发现:(1)流利性在自我介绍、主动发问和看图说话任务上,年级发展趋势不显著,但是在角色扮演任务上,随着年级的增长,流利性随之增加;精确性的年级发展趋势不显著;复杂性随着年级的升高而升高;(2)小学儿童的口语流利性在四个任务上从高到低为角色扮演、主动发问、自我介绍和看图说话;在对话任务上的精确性显著高于独白任务的精确性,并且看图说话任务的精确性最低;英语口语的复杂性在自我介绍任务上最高,其次是主动发问,角色扮演与看图说话任务的口语复杂性最低。