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331.
Nicotinic modulation of tone-evoked responses in auditory cortex reflects the strength of prior auditory learning 总被引:1,自引:0,他引:1
Liang K Poytress BS Weinberger NM Metherate R 《Neurobiology of learning and memory》2008,90(1):138-146
Nicotinic acetylcholine receptors (nAChRs) contribute to sensory-cognitive function, as demonstrated by evidence that nAChR activation enhances, and nAChR blockade impairs, neural processing of sensory stimuli and sensory-cognitive behavior. To better understand the relationship between nAChR function and behavior, here we compare the strength of nAChR-mediated physiology in individual animals to their prior auditory behavioral performance. Adult rats were trained on an auditory-cued, active avoidance task over 4 days and classified as “good,” “intermediate” or “poor” performers based on their initial rate of learning and eventual level of performance. Animals were then anesthetized, and tone-evoked local field potentials (LFPs) recorded in layer 4 of auditory cortex (ACx) before and after a test dose of nicotine (0.7 mg/kg, s.c.) or saline. In “good” performers, nicotine enhanced LFP amplitude and decreased response threshold to characteristic frequency (CF) stimuli, yet had opposite effects (decreased amplitude, increased threshold) on responses to spectrally distant stimuli; i.e., cortical receptive fields became more selective for CF stimuli. In contrast, nicotine had little effect on LFP amplitude in “intermediate” or “poor” performing animals. Nicotine did, however, reduce LFP onset latency in all three groups, indicating that all received an effective dose of the drug. Our findings suggest that nicotinic regulation of cortical receptive fields may be a distinguishing feature of the best-performing animals, and may facilitate sensory-related learning by enhancing receptive field selectivity. 相似文献
332.
Miasnikov AA Chen JC Gross N Poytress BS Weinberger NM 《Neurobiology of learning and memory》2008,90(1):125-137
The cholinergic system has been implicated in learning and memory. The nucleus basalis (NB) provides acetylcholine (ACh) to the cerebral cortex. Pairing a tone with NB stimulation (NBstm) to alter cortical state induces both associative specific tuning plasticity in the primary auditory cortex (A1) and associative specific auditory behavioral memory. NB-induced memory has major features of natural memory that is induced by pairing a tone with motivational reinforcers, e.g., food or shock, suggesting that the cholinergic system may be a “final common pathway” whose activation promotes memory storage. Alternatively, NB stimulation might itself be motivationally significant, either rewarding or punishing. To investigate these alternatives, adult male rats (n = 7) first formed a specific NB-induced memory (CS = 8.0 kHz, 2.0 s paired with NBstm, ISI = 1.8 s, 200 trials), validated by post-training (24 h) frequency generalization gradients (1–15 kHz) of respiration interruption that were specific to the CS frequency. Thereafter, they received the same level of NBstm that had induced memory, while confined to one quadrant of an arena, and later tested for place-preference, i.e., avoidance or seeking of the quadrant of NBstm. This NBstm group exhibited neither preference for nor against the stimulated quadrant, compared to sham-operated subjects (n = 7). The findings indicate that specific associative memory can be induced by direct activation of the NB without detectable motivational effects of NB stimulation. These results are concordant with a memory-promoting role for the nucleus basalis that places it “downstream” of motivational systems, which activate it to initiate the storage of the current state of its cholinergic targets. 相似文献
333.
The research was conducted to determine whether temperamental characteristics of neonates influence caregiver behavior as early as the second day of life. Visual attentiveness, activity, and irritability of 28 healthy newborns were rated during six 30-minute sessions. Derived scores represented the infant's behavior during the total observation time and during specified caretaking activities. Several categories of nurturant behaviors and types of comments directed toward each infant by nurse-caregivers were coded during independent sessions. Variations in caregiver behavior were shown by Pearson correlations to be related to independently assessed differences among neonates. Alert babies received the most nurturant and social contact; active infants received the least contact, but the most comments that reflected concern about their health; irritable infants were soothed most. The data clearly suggest that emerging infant temperament plays a role in shaping the caregiving environment by the second day of life. 相似文献
334.
Teresa L. Kramer Jacob D. Lindy Bonnie L. Green Mary C. Grace Anthony C. Leonard 《Suicide & life-threatening behavior》1994,24(1):58-67
Vietnam veterans (N = 232) recruited from three sources were assessed for suicidal thinking and behaviors, and symptoms of posttraumatic stress disorder (PTSD) and depression. Findings support the notion that suicidal thoughts are prevalent in this group, with veterans in psychotherapy reporting a greater likelihood of such symptoms (82.6%) than veterans in the community (35.7%) or those seeking assistance through a veteran's outreach center (66.7%). Thoughts of ending one's life and a previous suicide attempt were significantly correlated with a diagnosis of PTSD (r = .53, p < .001; and r = .33, p < .001, respectively). Veterans with a diagnosis of PTSD and depression or dysthymia were also more likely to report suicidal thinking and behaviors than veterans with only one of the diagnoses. 相似文献
335.
Bonnie J. Miller-McLemore 《Pastoral Psychology》2006,55(2):217-222
The purpose of this article is to suggest richer potential meanings of spiritual wisdom and theological reflection in response to a critical reading of Pamela Cooper-White's book, Shared wisdom: Use of the self in pastoral care and counseling. 相似文献
336.
337.
Amy L. Paine Patricia McCarthy Veach Ian M. MacFarlane Brittany Thomas Mary Ahrens Bonnie S. LeRoy 《Journal of genetic counseling》2010,19(6):570-584
Two prior studies suggest genetic counselors self-disclose primarily because patients ask them to do so (Peters et al., 2004; Thomas et al., 2006). However, scant research has investigated effects of counselor disclosure on genetic counseling processes and outcomes. In this study, 151 students (98 undergraduates, 53 graduates) completed one of three surveys describing a hypothetical genetic counseling session in which a patient at risk for FAP was considering whether to pursue testing or surveillance procedures. Dialogue was identical in all surveys, except for a final response to the question: “What would you do if you were me?” The counselor either revealed what she would do (Personal Disclosure), what other patients have done (Professional Disclosure), or deflected the question (No Disclosure). Imagining themselves as the patient, participants wrote a response to the counselor and indicated their perceptions of her. Participants rated the non-disclosing counselor significantly lower in social attractiveness than either disclosing counselor, and less satisfying than the professional disclosing counselor. Analysis of written responses yielded four themes: Made Decision, Sought Information, Expressed Thoughts/Feelings, and No Decision. Practice implications and research recommendations are provided. 相似文献
338.
Perceptions of the body are not restricted to the way the body “looks”; they may also extend to the way the body “functions”. This research explores body image among male and female adolescents using the Embodied Image Scale (EIS), which incorporates body function into body image. Adolescents (N = 1526, male = 673, female = 853) aged 12–17 (M = 13.83, SD = 1.02), from 26 Western Australian high schools were surveyed. Information was gathered on pubertal timing, body mass index (BMI) and body image. Participants reported significantly higher value of, behavioral-investment in, and satisfaction with the functional dimension of the body compared to the aesthetic dimension. After controlling for age, pubertal timing, and BMI, females reported significantly higher aesthetic values and aesthetic behavioral-investment, and lower aesthetic satisfaction, functional values, functional behavioral-investment and functional satisfaction than male participants. Grade, pubertal timing and BMI category differences were also explored. 相似文献
339.
Lisa Johnsen David MacKirnan Bonnie Spring Regina Pingitore Beth Kaplan Sommerfeld 《Health psychology》2002,21(3):279-287
Cultural stereotypes might help explain why smoking is less prevalent among Hispanic than non-Hispanic White women, whereas obesity is more prevalent. Hispanic (n = 130) and non-Hispanic White (n = 114) women rated their thoughts and feelings regarding a female smoker and an overweight woman. Ethnicity did not influence evaluations, but attitudes toward smokers were more positive among more acculturated Hispanic women, F(1, 66) = 9.9, p < .01. Less acculturated women evaluated an overweight woman more positively than a smoker, F(1, 28) = 5.65, p < .05; more acculturated women did the opposite, F( 1, 36) = 5.92, p < .05. Smokers evaluated smokers more positively than overweight women, F(1, 86) = 40.8, p < .01; nonsmokers did the opposite, F(l, 138) = 7.7, p < .01. Personal body weight did not influence evaluations. Acculturation and smoking status appear to have a greater influence than ethnicity or weight status on women's attitudes toward smoking and weight. 相似文献
340.
Some investigators propose that adolescents engage in risky behaviors mainly because they perceive themselves to be invulnerable to risk. However, studies have typically not included perceived benefits. In the current study, 5th, 7th, and 9th graders were surveyed about their perceptions of and experience with alcohol and tobacco. Results indicated that perceptions of the benefits were significantly related to drinking and smoking 6 months later, over and above perceptions of the risks, age of the respondent, and experience level. Further, the importance of benefits was replicated across 3 separate analyses. Experience with alcohol alone, especially positive experience, was also related to perception and behavior. These findings are discussed in terms of how to improve messages and influence adolescents' decisions regarding risk-taking behaviors. 相似文献