Risk Reduction Behaviors and Provider Communication Following Genetic Counseling and BRCA1 Mutation Testing in an African American Kindred

Little is known about the impact of cancer genetic counseling and testing on health behaviors in racial and ethnic subgroups. This prospective observational study examined use of risk reduction strategies following BRCA1 counseling and testing. Participants were female members of an African American kindred who received genetic education, counseling and testing (n = 40) and completed a 1-year follow-up interview. Mutation carriers were more likely to opt for breast (100%, 7/7) and ovarian (25%; 1 of 4) cancer surveillance than prophylactic surgery. Following genetic counseling, 71% (5/7) of the BRCA1 carriers who opted for surveillance reported having a mammogram within the year following receipt of their genetic test results. Ovarian cancer screening among mutation carriers increased from 0% at baseline to 25% (one of four) at 1 year. Compared to noncarriers (23%, 7/30), carriers (70%, 7/10) were more likely to discuss their BRCA1 test results with their primary health care providers. Surveillance for breast cancer was preferred to prophylactic surgery and chemoprevention as a way to reduce risk for these cancers. Our data indicate that patient-provider communication about BRCA1 test results is suboptimal.     

Philosophy and reflection: A critique of Frank Welz’s sociological and “processual” criticism of Husserl and Schutz

Frank Welz’s Kritik der Lebenswelt undertakes a sociology of knowledge criticism of the work of Edmund Husserl and Alfred Schutz that construes them as developing absolutist, egological systems opposed to the “processual” worldview prominent since the modern rise of natural science. Welz, though, misunderstands the work of Schutz and Husserl and neglects how their focus on consciousness and eidetic features pertains to the kind of reflection that one must undertake if one would avoid succumbing to absolutism, that uncovers the presuppositions of the processual worldview itself, and that secures a domain distinctive of philosophy over against sociology. Finally, Welz’s charge that Schutz favors a Neo-Kantian social scientific methodology contradictory to his phenomenology neglects the levels of Schutz’s discourse and ignores how the Weberian ideal-typical approach can be subsumed within phenomenology.     

IQ independence of measures of dysfunctional cognition

An important step in validating measures of dysfunctional cognition is to ensure that they are not confounded with general intelligence. We evaluated the Cognitions Checklist (Depression and Anxiety subscales), the Dysfunctional Attitudes Scale, and the Hopelessness Scale in a sample of 162 outpatients with depressive or anxiety disorders. These measures were not confounded with fluid or crystallized intelligence. Furthermore, correlations between the dysfunctional cognition scales and symptom severity measures were not attenuated when intelligence was statistically controlled.     

Interference effects in an auditory Stroop task: congruence and correspondence

Two auditory Stroop experiments are reported in which subjects responded vocally to the gender of the speaker of stimulus words. The interference effects found were broadly similar to those of a manual-response auditory Stroop paradigm although response-set effects appeared to operate in the data. In all experimental conditions responses were slower to stimulus words which named potential responses than to those words which did not. Such effects have not been found in previous manual-response experiments and it is suggested that the relatively high degree of S-R and of ideomotor compatibility in the vocal response task, compared with the manual task, may be responsible for this difference between the paradigms.The second experiment enabled a comparison to be made between the effects of congruence between relevant and irrelevant elements of the Stroop stimulus and the effects of correspondence between the response and the irrelevant aspect of the stimulus. A predominant influence of congruence was found when the subject responded using words semantically related to speaker gender, but an effect of correspondence was obtained when an arbitrary pairing of response word and speaker gender was required.     

Facilitating accuracy of imitative articulation through reception training

Accuracy of imitation of nonsense words was examined in first- and second-grade children (65–99 months of age) as a function of prior reception training. Two experiments were conducted, involving within-subject comparisons. In the first, one group of words was trained as labels for nonsense objects, a second received noncontingent feedback yoked to the labeling words, a third was presented an equal number of times to control for exposure, and a fourth group was not included in the training phase. Testing involved accuracy of imitation of all four groups of words. Both the feedback and exposure words were imitated less accurately than the labeling words, but more accurately than the nonexposure controls. The second experiment examined the length of the label-object association, using an overtraining procedure. Words which came under the discriminative control of objects for greater numbers of trials were imitated more accurately than those meeting only a minimum discrimination criterion.     

The role of grammatical class on word recognition

The double dissociation between noun and verb processing, well documented in the neuropsychological literature, has not been supported in imaging studies. Recent imaging studies, in fact, suggest that once confounding with semantics is eliminated, grammatical class effects only emerge as a consequence of building frames. Here we assess this hypothesis behaviorally in two visual word recognition experiments. In Experiment 1, participants made lexical decisions on verb targets. We manipulated the grammatical class of the prime words (either nouns or verbs and always introduced in a minimal phrasal context, i.e., “the + N” or “to + V”), and their semantic similarity to a target (related vs. unrelated). We found reliable effects of grammatical class, and no interaction with semantic similarity. Experiment 2 further explored this grammatical class effect, using verb targets preceded by semantically unrelated verb vs. noun primes. In one condition, prime words were presented as bare words; in the other, they were presented in the minimal phrasal context used in Experiment 1. Grammatical class effects only arose in the latter but not in the former condition thus providing evidence that word recognition does not recruit grammatical class information unless it is provided to the system.     

Motivationally neutral stimulation of the nucleus basalis induces specific behavioral memory

The cholinergic system has been implicated in learning and memory. The nucleus basalis (NB) provides acetylcholine (ACh) to the cerebral cortex. Pairing a tone with NB stimulation (NBstm) to alter cortical state induces both associative specific tuning plasticity in the primary auditory cortex (A1) and associative specific auditory behavioral memory. NB-induced memory has major features of natural memory that is induced by pairing a tone with motivational reinforcers, e.g., food or shock, suggesting that the cholinergic system may be a “final common pathway” whose activation promotes memory storage. Alternatively, NB stimulation might itself be motivationally significant, either rewarding or punishing. To investigate these alternatives, adult male rats (n = 7) first formed a specific NB-induced memory (CS = 8.0 kHz, 2.0 s paired with NBstm, ISI = 1.8 s, 200 trials), validated by post-training (24 h) frequency generalization gradients (1–15 kHz) of respiration interruption that were specific to the CS frequency. Thereafter, they received the same level of NBstm that had induced memory, while confined to one quadrant of an arena, and later tested for place-preference, i.e., avoidance or seeking of the quadrant of NBstm. This NBstm group exhibited neither preference for nor against the stimulated quadrant, compared to sham-operated subjects (n = 7). The findings indicate that specific associative memory can be induced by direct activation of the NB without detectable motivational effects of NB stimulation. These results are concordant with a memory-promoting role for the nucleus basalis that places it “downstream” of motivational systems, which activate it to initiate the storage of the current state of its cholinergic targets.     

Parent and Child Factors Associated with Household versus Community Adversity among Black and Hispanic Children

Journal of Child and Family Studies - The purpose of this study was to describe exposure to within-household and community adverse childhood experiences (ACEs) and to identify child- and...