The tortuous route from genes to behavior: A neuroconstructivist approach

In their excitement at using the human genome project to uncover the functions of specific genes, researchers have often ignored one fundamental factor: the gradual process of ontogenetic development. The view that there might be a gene for spatial cognition or language has emanated from a focus on the structure of the adult brain in neuropsychological patients whose brains were fully and normally developed until their brain insult. The developing brain is very different. It starts out highly interconnected across regions and is neither localized nor specialized at birth, allowing interaction with the environment to play an important role in gene expression and the ultimate cognitive phenotype. This article takes a neuro constructivist perspective, arguing that domain-specific end states can stem from more domain-general start states, that associations may turn out to be as informative as dissociations, and that genetic mutations that alter the trajectory of ontogenetic development can inform nature/nurture debates.     

Part-list cuing in amnesic patients: evidence for a retrieval deficit

Part-list cuing--the detrimental effect of the presentation of a subset of learned items on recall of the remaining items--was examined in amnesic patients and healthy control subjects. Subjects studied two types of categorized item lists: lists in which each category consisted of strong and moderate items and lists in which each category consisted of weak and moderate items. The subjects recalled a category's strong and weak items in either the presence of or absence of the moderate items serving as retrieval cues. In healthy subjects, part-list cuing impaired recall of the strong items but not of the weak items; in amnesics, part-list cuing impaired recall of both types of items. Part-list cuing is often attributed to a change in the retrieval process from a more effective one when cues are absent to a less effective one when they are present. On the basis of this view, our results indicate that part-list cuing causes a stronger retrieval inefficiency in amnesic patients than in healthy people.     

Measures of Hindu pathways: development and preliminary evidence of reliability and validity

The authors examined religious practices of Hindus in the United States and developed measures of their religious pathways. Based on reviews of the psychology of religion, Hindu literature, and interviews with Hindus (N=15), 4 religious pathways were identified: devotion, ethical action, knowledge, and physical restraint/yoga. Items reflecting these pathways were generated and administered to a pilot sample (N=42) and then mailed to a sample across the United States (N=182). Consistent with Hindu theology, participants endorsed 4 religious pathways. Results indicated that the measures of the religious pathways possessed adequate psychometric properties and were predictive of mental and physical well-being. Additional findings emphasized the need to attend to age, marital status, and acculturation when studying religious practices among Hindus.     

Some antiepileptic compounds impair learning by rats in a Morris water maze

In the present experiments, we investigated the effects of several commonly employed antiepileptic drugs on the performance of adult rats in a Morris water maze task. We found that phenytoin treatment produced the most deleterious performance impairments across all days of training, and that these performance deficits are not likely due to any general sensorimotor impairments. Carbamazepine had milder, but detectable negative effects, as carbamazepine-treated animals exhibited initial acquisition deficits, but rapidly achieved escape levels comparable to controls. In marked contrast, valproate and ethosuximide had no detectable effects on learning in the water maze. These results parallel previous findings in rats treated with these compounds and tested in an instrumental learning task, and are in general agreement with the human clinical literature. To the extent that one might wish to minimize learning deficits associated with maintenance on antiepileptic drugs, phenytoin is definitely not the treatment of choice, while valproate or ethosuximide are apparently much less disruptive.     

Social influences on cognitive processing in enacted social support: effects on receivers’ cognitive appraisals,emotion, and affiliation

Background and objectives. Social support is linked with psychological health, but its mechanisms are unclear. We examined supporters’ influence on recipients’ cognitive processing as a mechanism of effects of support on outcomes associated with depression.

Design/methods. 2?×?2 between-subjects experiment. 147 participants (1) experienced a negative event (false feedback); (2) received social support modeling one of two contrasting cognitive processing modes (abstract/evaluative or concrete/experiential); (3) generated explanations for the event, later coded for processing mode and internal/external causal attribution; and (4) reported on emotion, perceptions of self and future, and social affiliation. To examine relational effects, half of participants were led to perceive the supporter as similar to themselves via a shared birthday manipulation.

Results. Support condition influenced participants’ processing mode and causal attributions as predicted. Abstract/evaluative support led to more positive emotion and self-perceptions, and less pessimistic expectancies for the future than concrete/experiential support. Perceived similarity moderated effects on beliefs about an upcoming social interaction, magnifying positive affiliation outcomes of abstract/evaluative versus concrete/experiential support.

Conclusions. Processing modes that are generally maladaptive at the intrapersonal level may be adaptive (and vice versa) when they are interpersonally influenced, and perceived similarity may facilitate interpersonal effects of processing mode on affiliation.