Musculoskeletal pain complaints and performance on cognitive tasks over the adult life span

The present study aimed at comparing participants with and without self reported musculoskeletal pain in a normal population with regard to performance on a range of tests for episodic memory, semantic memory, and other cognitive functions and to see if expected differences interacted with age. The results showed that participants with pain performed worse on a range of tasks as compared to participants without pain, and that these differences occurred regardless of age. The most robust effects of pain were displayed on tests for vocabulary and construction ability as these were the only effects that remained significant after controlling for years of education and reported depression in separate analyses. When depression and education were controlled for in the same analysis, even these effects were eliminated, suggesting interplay between pain, depressive status, and educational level in the negative effects on cognitive functioning.     

Abrupt, but not gradual visuomotor distortion facilitates adaptation in children with developmental coordination disorder

A previous experiment investigating visuomotor adaptation in typically developing children and children with Developmental Coordination Disorder (DCD) suggested poor adaptation to an abruptly induced visuomotor perturbation. In the current study, using a similar center-out drawing task, but administering either an abrupt or a gradual perturbation, and twice as many adaptation trials, we show that typically developing children are well able to successfully update an existing internal model in response to a 60 degrees rotation of the visual feedback, independent of the perturbation condition. Children with DCD, however, updated their internal map more effectively during exposure to an abrupt visuomotor perturbation than to a gradual one. This may suggest that the adaptation process in children with DCD responds differently to small vs. large steps of visuomotor discrepancies. Given the known role of the cerebellum in providing an error signal necessary for updating the internal model in response to a gradual visuomotor distortion, the results of our study add to the growing body of evidence implicating compromised cerebellar function in DCD.     

Global Benefit-risk Evaluation of Antidepressant Action: Comparison of Pooled Data for Venlafaxine,SSRIs, and Placebo

Do antidepressants have an equivalent risk-benefit ratio? Venlafaxine, a serotonin-norepinephrine reuptake inhibitor, is an effective antidepressant for treating major depression. The results of some clinical studies have suggested that venlafaxine may have more potent efficacy in sustaining remission in patients with major depression. Comparative clinical studies, however, lack suitable power to discern treatment differences in safety and also lack a quantitative basis for comparing risk and benefit. A global benefit-risk analysis of pooled data from eight randomized, double-blind, clinical trials of the safety and efficacy of venlafaxine and selective serotonin reuptake inhibitors (SSRIs) was performed. By using the ratio measure of risk-benefit, patients treated with venlafaxine (n=851) for 6-8 weeks experienced a relative gain of 1.57 compared with SSRI-treated patients (n=743) and a relative gain of 2.27 compared with placebo-treated patients (n=439). Subgroup analyses showed a relative gain of 1.35 for venlafaxine-treated patients (n=538) compared with fluoxetine-treated patients (n=549) and a relative gain of 2.53 compared with placebo-treated patients (n=357). A dose-response relationship was apparent between low (<75 mg/day), medium (75-150 mg/day), and high (>150 mg/day) dosages of venlafaxine; r values were 0.758, 0.822, and 1.181, respectively (P=.023, high dosage versus placebo; P=.030, medium dosage versus placebo). Important differences in risk and benefit exist between venlafaxine and SSRIs as a group compared with fluoxetine alone. A significant gain in benefit-risk in the treatment of major depression was observed with an increase in venlafaxine dosage from 75->150 mg/day.     

FOK判断等级及其准确性的实验研究

通过实验集中控制了ＦＯＲ判断等级及其准确性的影响因素。实验以中文字串为学习材料,使用组内设计的实验方法研究了被激活信息的量和强度对ＦＯＤ等级及准确性的影响。实验结果表明：ＦＯＫ判断的等级是由被激活信息的总量决定;的,和被激活信息的正确与否无关;ＦＯＤ判断的准确性是由被激活信息的强度决定的;且二者是在内联系的。     

人类自我意识的多重起源：兼论精神分裂症的进化论解释

将ＰｏｗｖｉｎｅｌｌｉａｎｄＣａｎｔ提出的栖处降服假说推广以生态位－亚生态位中的维数－参量之间的更一般的互相降服情景,提出了人类的自我意识的多重起源的假设及对精神分裂症作出了进化方面的解释,最后对意识起源之谜进行了探讨和推测：意识具有精炼信息的功能。     

Depressive symptoms in Swedish adolescents

This study examined the prevalence of self-reported depressive symptoms in a Swedish urban school sample (n=547) aged 13 to 18 years using the Beck Depression Inventory (BDI). The data obtained were examined with respect to sex and age differences and compared with a clinical sample of adolescents hospitalized because of psychiatric disturbances. The results indicated a strong preponderance of depressive symptoms among girls in the school sample, in particular for the severe symptom level. Eight percent of subjects reported depressive symptoms sufficiently high to be classified as a moderate, and 2% as a severe, level of depression. Factor analysis yielded four factors representing dysphoric mood, social activity, relationship, and food-related dimensions. The BDI showed a high internal consistency, and test-retest reliability calculated for a 2-week and a 2-month interval revealed strong correlations. The means of total scores on the BDI for the clinical sample were significantly higher than for those in the school sample.     

Defects of immediate memory related to the cerebral blood flow distribution

Different forms of memory defects were studied in 16 patients with organic dementia. The test performance was related to the regional cerebral blood flow (rCBF) in the left (dominant) hemisphere. Verbal memory (Paired Associates) correlated to the blood flow in temporal and parietal regions. Spatial recognition (Memory for Objects, Memory for Geometrical Design) correlated to the temporal and lower frontal regions. One spatial memory test (Visual Retention test) correlated to the temporal region only. Another spatial memory test (Memory for Design) did not show correlations to any regions of the dominant hemisphere. Finally it was found that the hemisphere mean flow values did not correlate to performance. This emphasizes the main finding—the regional correlations. It is concluded that memory performance involves various extratemporal regions depending upon the specific quality of the memory task to be performed.