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221.
The hypothesis of independent processing channels was tested in a letter-recognition task. Letter space and retinal position were varied for both unilateral and bilateral presentations of two-letter configurations. The response latencies indicated contour interference effects for small letter spaces as well as a different type of processing delay which increased rapidly with increased letter distance from the fixation point. The latter effect was assumed to represent an interaction between the feature extraction processes of the adjacent letters. Since the processing capacity decreases as a function of the distance from the fovea, the reaction times were correspondingly lengthened. 相似文献
222.
Bo Hagberg 《Psychological research》1980,41(2-3):211-215
Summary The relationship between psychometric performance and regional cerebral blood flow (rCBF) measurement in a series of patients suffering from presenile dementia is discussed. An evaluation of central concepts in the late Professor A.R. Luria's dynamic localization model for behavior determination is made. A new indirect measurement of regional cerebral metabolism (rCBF) is used. In general, support is obtained from Luria's model for the interpretation of the relation between psychometric results and the rCBF data. 相似文献
223.
224.
Bo Chen 《Frontiers of Philosophy in China》2006,1(4):539-560
The debate on the yan-yi relation was carried out by Chinese philosophers collectively, and the principles and methods in the debate still belong
to a living tradition of Chinese philosophy. From Yijing (Book of Changes), Lunyu (Analects), Laozi and Zhuangzi to Wang Bi, “yi” which cannot be expressed fully by yan (language), is not only “idea” or “meaning” in the human mind, but is also some kind of ontological existence, which is beyond
yan and emblematic symbols, and unspeakable. Thus, the debate on the yan-yi relation refers firstly to metaphysics, secondly to moral philosophy, and then to epistemology and philosophy of language.
Guided by this view, this paper recalls the source of the debate on the yan-yi relation to Yijing and Lunyu, distinguishes four meanings of “yi” in Chinese philosophy, and reconstructs three arguments. These arguments are the “yan cannot express yi fully” argument, “forget yan once you get yi” argument, and “yan can express yi fully” argument. Finally, this paper exposes and comments on those principles, methods and the general tendency shown in
the debate from the following five aspects: starting point, value-preference, methodology, texts (papers and books), and influences.
__________
Translated from Jianghai Xuekan 江海学刊 (Jianghai Academic Studies), 2005 (3) 相似文献
225.
“镜像”的内涵与外延:围绕镜像神经元的争议 总被引：1，自引：0，他引：1
镜像神经元被认为是改变认知神经科学的重要发现,它的发现为迄今为止许多行为实验难以检验的心智或认知现象提供了一个统一的研究视角。然而,镜像神经元在社会认知活动中的重要作用却引起了研究者的激烈争论。系统回顾镜像神经元研究中的争议,可以尝试以争论焦点出现的逻辑关系和性质为依据将其划分为两类:一类是关于镜像"内涵"的争议,主要包括镜像神经元是否存在及其起源的争议。另一类则主要围绕镜像"外延"的争议,即有关镜像神经元系统和镜像机制的争议。未来的研究必须摒弃将镜像神经元视为"认知科学圣杯"的神经还原主义倾向,将之视为一个由多个子系统组成的开放的复杂巨系统,并将焦点转向关注镜像机制。 相似文献
226.
227.
Inhibition is a widely used notion proposed to account for data obtained in choice reaction time (RT) tasks. However, this concept is weakly supported by empirical facts. In this paper, we review a series of experiments using Hoffman reflex, transcranial magnetic stimulation and electroencephalography to study inhibition in choice RT tasks. We provide empirical support for the idea that inhibition does occur during choice RT, and the implications of those findings for various classes of choice RT models are discussed. 相似文献
228.
The effect of violent video games on aggressive behavior is an important topic in the field of game research. Recently, growing evidence suggests that justified game violence decreases feelings of guilt caused by in-game immoral behavior. However, little is known about the impact on aggressive behavior, and whether other factors moderate this effect. In a two-factor experiment, we tested the impact of justification of video game violence on aggressive behavior, and whether this effect would be enhanced by game immersion. Pilot experiment 1 (N = 60) and pilot experiment 2 (N = 40) demonstrated that the justification of violence and game immersion was successfully controlled by avatar and graphics quality. In the Main experiment, 123 participants played one of four conditions of a video game (2 [justification: justified vs. unjustified violence] × 2 [immersion: high vs. low immersion]) and it was found that participants who played in the justified violence condition reported greater aggressive behavior than those in the unjustified violence condition. In addition, participants who played in high immersion reported greater aggressive behavior than those in low immersion. However, game immersion did not moderate the effects of justified violence. This unexpected effect is likely due to participants' distancing themselves from and identifying less with their violent avatars. 相似文献
229.
J.Y. Hilary Wong Bo Angela Wan Tom Bland Marcella Montagnese Alex D. McLachlan Cahir J. O'Kane Shuo Wei Zhang Liria M. Masuda-Nakagawa 《Learning & memory (Cold Spring Harbor, N.Y.)》2021,28(2):53
Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by noradrenergic input in mammals, or octopamine (OA) in insects. To understand the circuit mechanisms of this signaling, we characterized the function of two OA neurons, sVUM1 neurons, that originate in the subesophageal zone (SEZ) and target the input region of the memory center, the mushroom body (MB) calyx, in larval Drosophila. We found that sVUM1 neurons target multiple neurons, including olfactory projection neurons (PNs), the inhibitory neuron APL, and a pair of extrinsic output neurons, but relatively few mushroom body intrinsic neurons, Kenyon cells. PN terminals carried the OA receptor Oamb, a Drosophila α1-adrenergic receptor ortholog. Using an odor discrimination learning paradigm, we showed that optogenetic activation of OA neurons compromised discrimination of similar odors but not learning ability. Our results suggest that sVUM1 neurons modify odor representations via multiple extrinsic inputs at the sensory input area to the MB olfactory learning circuit.Behavioral choices depend on discrimination among “sensory objects,” which are neural representations of multiple coincident sensory inputs, across a range of sensory modalities. For example, “odor objects” (Gottfried 2009; Wilson and Sullivan 2011; Gire et al. 2013) are represented in sparse ensembles of neurons, that are coincidence detectors of multiple parallel inputs from odor quality channels. This principle is used widely in animals, including in mushroom bodies (MBs), the insect center for associative memory (Masuda-Nakagawa et al. 2005; Honegger et al. 2011), and in the piriform cortex (PCx) of mammals (Stettler and Axel 2009; Davison and Ehlers 2011).The selectivity of sensory representations can be modulated dynamically by changes in behavioral state, allowing an animal to learn and respond according to perceptual task. In mammals, the noradrenergic system originating in the locus coeruleus (LC) is implicated in signaling behavioral states such as attention, arousal and expectation (Aston-Jones and Cohen 2005; Sara and Bouret 2012).In insects, octopamine (OA), structurally and functionally similar to noradrenalin (NA) in mammals (Roeder 2005), can mediate changes in behavioral state that often promote activity; for example, sensitization of reflex actions in locusts (Sombati and Hoyle 1984), aggressive state in crickets (Stevenson et al. 2005), initiation and maintenance of flight state (Brembs et al. 2007; Suver et al. 2012), and enhanced excitability of Drosophila motion detection neurons during flight (Strother et al. 2018). Another role of OA is as a reward signal: A single OA neuron, VUMmx1, mediates the reinforcing function of unconditioned stimulus in the honeybee proboscis extension reflex (Hammer 1993; Hammer and Menzel 1998; Menzel 2012). In Drosophila, acquisition of appetitive memory is impaired in TβH mutants, unable to synthesize OA (Schwaerzel et al. 2003), and activation of OA neurons can substitute reinforcing stimulus in appetitive learning (Schroll et al. 2006). Moreover, OA receptors are necessary for reward learning in Drosophila (Burke et al. 2012) and crickets (Matsumoto et al. 2015).To understand the neural mechanisms of OA in higher order sensory discrimination, we used the simple sensory “cortex” of larval Drosophila, the calyx, which is the sensory input region of the mushroom bodies (MBs), the insect memory center. Here, each MB neuron (Kenyon cell [KC]) typically arborizes in several glomeruli, most of which are organized around the terminus of an olfactory projection neuron (PN); KCs thus combinatorially integrate multiple sensory input channels (Masuda-Nakagawa et al. 2005) and are coincidence detectors of multiple inputs. The APL provides inhibitory feedback (Lin et al. 2014; Masuda-Nakagawa et al. 2014) and helps to maintain KC sparse responses and odor selectivity (Honegger et al. 2011), analogous to inhibition in the mammalian PCx (Poo and Isaacson 2009; Stettler and Axel 2009; Gire et al. 2013). Thus, odors are represented as a sparse ensemble of KCs that are highly odor selective, a property beneficial for memory (Olshausen and Field 2004).In addition, the larval MB calyx is innervated by two OA neurons, sVUMmd1 and sVUMmx1, ventral unpaired medial neurons with dendritic fields originating in the mandibular and maxillary neuromeres, respectively, of the SEZ in the third instar larva (Selcho et al. 2014). sVUMmd1 and sVUMmx1 are named as OANa-1 and OANa-2, respectively, in the EM connectomic analysis of a 6-h first instar larva (Eichler et al. 2017; Supplemental Fig. 3 of Saumweber et al. 2018). These sVUM1 neurons also innervate the first olfactory neuropile of the antennal lobe (AL). This pattern of innervation is conserved in other insects, for example, the dorsal unpaired median (DUM) neurons in locusts (for review, see Bräunig and Pflüger 2001), the VUMmx1 neuron in honeybees (Hammer 1993; Schröter et al. 2007), and OA-VUMa2 neurons in adult Drosophila (Busch et al. 2009). In adult Drosophila, OA-VUMa2 neurons also show a dense innervation of the lateral horn, implicated in innate behaviors (Busch et al. 2009). The widespread innervation of the insect olfactory neuropiles also resembles the widespread NA innervation of mammalian olfactory processing areas, such as the olfactory bulb, and piriform cortex, by LC neurons originating in the brainstem.We characterized the innervation pattern and synaptic targets of sVUM1 neurons in the calyx, with MB intrinsic and also extrinsic neurons, the localization of the OA receptor Oamb in the calyx circuit, and the impact of sVUM1 neuron activation on behavioral odor discrimination. For this we used an appetitive conditioning paradigm, and tested the ability of larvae to discriminate between similar odors, as opposed to dissimilar odors. Since the larval connectome is based on a single brain, at first instar stage before octopaminergic connections have become as extensive as at third instar, and to obtain a comprehensive understanding of the synaptic targets of sVUM1s in the third-instar larval calyx, we extended our analysis to previously unanalyzed connectivity of VUM1s, to APL and PNs. Further, we combined light microscopy of third-instar larvae with the connectome described by Eichler et al. (2017).We find that sVUM1 neurons in third-instar larvae contact all the major classes of calyx neuron to some degree, consistent with EM synaptic analysis of the 6-h larva (Eichler et al. 2017). A GFP fusion of the OA receptor Oamb is localized in the terminals of PNs, and activating a subset of five SEZ neurons, including sVUM1 neurons, can affect discrimination of similar odors, without affecting underlying olfactory learning and memory ability. We suggest a broad modulatory effect of sVUM1 neurons in the calyx, including a potential role in modulating PN input at the second synapse in the olfactory pathway. 相似文献
230.
In this article, we analyse one of the most famous recent thought‐experiments in philosophy, namely Donald Davidson's Swampman. Engaging recent commentators on Davidson's Swampman as well as analysing the spatio‐temporal conditions of the thought‐experiment, we will show how the ‘experiment’ inevitably fails. For it doesn't take seriously some of its own defining characteristics: crucially, Swampman's creation of a sudden in a place distinct from Davidson's. Instead of denigrating philosophical thought‐experiments per se, our analysis points towards considering thought‐experiments in a different sense: imaginary scenarios helpfully self‐deconstructing rather than constituting substantive philosophical resources. 相似文献