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131.
132.
羧化不全骨钙素(ucOCN)是骨中成骨细胞分泌的特异性蛋白,因其在调控神经发育、神经可塑性等中的重要角色而受到神经科学领域关注。"骨-脑"串联"对话"是骨内分泌-神经介导的应答系统,ucOCN透过血脑屏障后介导单胺类神经递质、神经内分泌、神经免疫、神经再生及基因表达等机制,进而作用于海马CA3区、扣带回等脑区功能发挥来调节抑郁发生及改善。而ucOCN作为骨源性力学刺激敏感基因,运动上调其表达后进入血液循环,通过介导5-HT/GABA分泌、HPA轴功能、炎症反应、神经营养因子(BDNF等)表达或信号途径(如GSK3β/β-catenin、TLR4/miR-223/NLRP3等)激活等来实现"骨串联脑",发挥运动抗抑郁作用。通过对骨源性因子ucOCN介导脑区功能变化从而实现运动抗抑郁的作用机制进行探讨、梳理,一方面有助于更深入了解骨内分泌功能,另一方面为抑郁发生、改善和运动抗抑郁研究提供新的理论基础和研究思路。 相似文献
133.
Synthese - In their 2010 (Erkenntnis 73:393–412) paper, Dizadji-Bahmani, Frigg, and Hartmann (henceforth ‘DFH’) argue that the generalized version of the Nagel–Schaffner... 相似文献
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The development of the understanding of the words and and or was studied. Children in the age interval 2:0–7:6 received two tests of word understanding, varying in the degree to which the context of the test items contributed in determining the meaning of the connectives, and one test of spontaneous usage. The results from the tests of word understanding showed that the context variable facilitated small children's responding, and that most reponses were correct at the age of four and beyond. The results from the production test indicated that and was used to express enummerations and or to express alternatives. The difference between the linguistic and the logical meaning of the connectives was discussed. 相似文献
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Journal for General Philosophy of Science - Die Wissenschaftspsychologie wird als ein Gebiet interdisziplinärer Forschungen an der Grenze zwischen Psychologie und allgemeiner Theorie und... 相似文献
138.
Clustering with relational constraint 总被引:2,自引:0,他引:2
The paper deals with clustering problems where grouping is constrained by a symmetric and reflexive relation. For solving clustering problems with relational constraints two methods are adapted: the standard hierarchical clustering procedure based on the Lance and Williams formula, and local optimization procedure, CLUDIA. To illustrate these procedures, clusterings of the European countries are given based on the developmental indicators where the relation is determined by the geographical neighbourhoods of countries.Extended version of the paper presented at the European meeting of the Psychometric Society, Groningen, June, 19–21, 1980.This work was supported in part by the Boris Kidri Fund, Yugoslavia. 相似文献
139.
A mean interstimulus interval (ISI) of 10 sec. resulted in significantly-shorter RTs to a single light stimulus than a 30 sec. average ISI. During a second workperiod the groups performing under each of the two ISI conditions were divided into four subgroups given 0, 25, 50 or 75% interspersion of an additional stimulus (sound). With short ISIs the condition of maximum predictability of event structure (light stimulus only) gave the shortest average RTs. With lessened predictability (increased proportion of the sound stimulus) there was a slight monotonous increase in RT. With long ISIs the same relationship was curvilinear, i.e. 25% interspersion of sound stimulus was most effective in preserving vigilance. 相似文献
140.
Kosta Došen 《Studia Logica》1985,44(1):39-70
This paper, a sequel to Models for normal intuitionistic modal logics by M. Boi and the author, which dealt with intuitionistic analogues of the modal system K, deals similarly with intuitionistic analogues of systems stronger than K, and, in particular, analogues of S4 and S5. For these prepositional logics Kripke-style models with two accessibility relations, one intuitionistic and the other modal, are given, and soundness and completeness are proved with respect to these models. It is shown how the holding of formulae characteristic for particular logics is equivalent to conditions for the relations of the models. Modalities in these logics are also investigated.This paper presents results of an investigation of intuitionistic modal logic conducted in collaboration with Dr Milan Boi. 相似文献