血栓形成及抗凝药物在临床应用中的思考

血栓栓塞性疾病对人类的健康已构成了极大的危害.在临床工作中应深入了解血栓形成以及凝血机制的新概念,了解传统抗凝药物的特点、以及凝血因子靶点Ⅹa、Ⅱa等特异性抑制为基础的新型抗凝药物的研发进展,合理使用抗凝药物,提高对血栓栓塞性疾病的诊治水平.     

fMRI correlates of inhibition of return in perifoveal and peripheral visual field

When a target appears in the same peripheral location as a previous cue, responding is typically delayed if the cue-target interval is relatively long. This phenomenon is termed inhibition of return (IOR) and has been suggested to reflect an attentional bias in favour of novel visual space. It has been demonstrated recently that IOR is much stronger in the far periphery than in the perifoveal visual field. The present study further investigated the neural mechanisms underlying this eccentricity effect of IOR with an event-related fMRI technique. The results demonstrated a stronger activation in visual cortex for perifoveal processing and a broader activation in multiple brain areas for peripheral processing. When IOR effects were compared between these two areas, a stronger activation of the fronto-parietal network was evidenced for perifoveal versus peripheral IOR, while the prefrontal cortex was more strongly involved in the peripheral IOR versus perifoveal IOR. These results suggest that different neural mechanisms are mediating the dissociable inhibitory functions between the perifoveal and peripheral visual field.     

One first? Acquisition of the cardinal and ordinal uses of numbers in preschoolers

We studied the acquisition of the ordinal meaning of number words and examined its development relative to the acquisition of the cardinal meaning. Three groups of 3-, 4-, and 5-year-old children were tested in two tasks requiring the use of number words in both cardinal and ordinal contexts. Understanding of the counting principles was also measured by asking the children to assess the correctness of a cartoon character's counting in both contexts. In general, the children performed cardinal tasks significantly better than ordinal ones. Tasks requiring the production of the number for a given quantity or position were solved more accurately than those testing the ability to select a set of n objects or the object in the nth position. Different profiles were obtained for the principles; those principles shared by the two contexts were mastered earlier in the cardinal context. Regarding order (ir)relevance, older children adhered to rigid ways of counting, producing better results in the ordinal context and incorrect rejections in the cardinal trials. Altogether, our data indicate that the acquisitions of cardinal and ordinal meanings of numbers are related, and cardinality precedes the development of ordinality.     

Ingroup ambivalence and experienced discomfort: the moderating roles of affective versus cognitive attitudinal basis, group identification, as mediated by negative beliefs about the ingroup

Prior research has found individuals' reactions to vary depending on whether such associations are activated by emotions (an affective basis) or by beliefs (a cognitive basis) about the object's properties. Accordingly, this conceptual distinction should be relevant also for the discomfortive responses to one's ambivalent attitudes regarding fellow group members (or the ingroup). Findings from two studies support the argument that ambivalence-associated discomfort a) is a general tendency when it regards affect-based ambivalence towards fellow group members, while b) only holds for the more identified group members when ambivalence concerns beliefs about the ingroup, and for this latter group members c) this tendency is driven by the strength of their negative beliefs about the ingroup or fellow group members.     

Goal relevance moderates evaluative conditioning effects

An important process by which preferences emerge is evaluative conditioning, defined as a change in the evaluation of a stimulus by pairing it repeatedly and consistently with an affective stimulus. The current research focuses on the role of motivation in this learning process. Specifically, it was investigated whether a conditioning procedure that is relevant to an individual's current goals is more effective than an irrelevant procedure. To this end, beverages were conditioned with either disgusted faces (relevant) or fearful faces (irrelevant). The results showed that thirsty(rather than non-thirsty) participants’ choice and evaluation of beverages were influenced by pairing beverages with disgust but not with fear. As similar results were obtained under optimal and suboptimal presentation of the conditioned stimuli, it is suggested that goals can affect automatic, associative learning, adding to the emerging body of research demonstrating that goals unconsciously affect evaluative processes.     

Biased allocation of faces to social categories

Three studies show that social categorization is biased at the level of category allocation. In all studies, participants categorized faces. In Studies 1 and 2, participants overallocated faces with criminal features--a stereotypical negative trait--to the stigmatized Moroccan category, especially if they were prejudiced. On the contrary, the stereotype-irrelevant negative trait stupid did not lead to overallocation to the Moroccan category. In Study 3, using the stigmatized category homosexual, the previously used negative trait criminal--irrelevant to the homosexual stereotype--did not lead to overallocation, but the stereotype-relevant positive trait femininity did. These results demonstrate that normative fit is higher for faces with stereotype-relevant features regardless of valence. Moreover, individual differences in implicit prejudice predicted the extent to which stereotype-relevant traits elicited overallocation: Whereas more negatively prejudiced people showed greater overallocation of faces associated with negative stereotype-relevant traits, they showed less overallocation of faces associated with positive stereotype-relevant traits. These results support our normative fit hypothesis: In general, normative fit is better for faces with stereotypical features. Moreover, normative fit is enhanced for prejudiced individuals when these features are evaluatively congruent. Social categorization thus may be biased in itself.     

If-Clauses and Probability Operators

Adams’ thesis is generally agreed to be linguistically compelling for simple conditionals with factual antecedent and consequent. We propose a derivation of Adams’ thesis from the Lewis-Kratzer analysis of if-clauses as domain restrictors, applied to probability operators. We argue that Lewis’s triviality result may be seen as a result of inexpressibility of the kind familiar in generalized quantifier theory. Some implications of the Lewis-Kratzer analysis are presented concerning the assignment of probabilities to compounds of conditionals.     

Effects of training condition on the contribution of specific items to relational processing in baboons (Papio papio)

Relational processing involves learning about the relationship between or among stimuli, transcending the individual stimuli, so that abstract knowledge generalizable to novel situations is acquired. Relational processing has been studied in animals as well as in humans, but little attention has been paid to the contribution of specific items to relational thinking or to the factors that may affect that contribution. This study assessed the intertwined effects of item and relational processing in nonhuman primates. Using a procedure that entailed both expanding and contracting sets of pictorial items, we trained 13 baboons on a two-alternative forced-choice task, in which they had to distinguish horizontal from vertical relational patterns. In Experiment 1, monkeys engaged in item-based processing with a small training set size, and they progressively engaged in relation-based processing as training set size was increased. However, in Experiment 2, overtraining with a small stimulus set promoted the processing of item-based information. These findings underscore similarities in how humans and nonhuman primates process higher-order stimulus relations.     

The spiritual benefits of travel for senior tourists

This research explores the spiritual benefits of travel for older adults and illustrates how travel meets seniors' self‐actualization and spiritual growth needs. The theoretical point of departure for this research is seniors' quest for meaning and self‐actualization, which act as push factors inducing older adults to travel. Semistructured depth interviews were conducted with 16 retired senior informants who had extensive travel experience. Using an interpretive method, this research reveals four key themes that illustrate the spiritual benefits of travel, thereby extending the growing literature on the motivations of senior travelers. These themes are described as “traveling generates meaning for older adults,” “traveling reveals the self to older adults,” “traveling encourages older adults to better understand others,” and “traveling enables older adults to better understand their relationship to nature”. In sum, the themes describe how older adults may meet their unique spiritual needs through travel and thereby enhance their spiritual development. This research represents one of a few studies examining senior tourism to employ an interpretive method and provides rich insights as a result. This research also extends the emerging research on spirituality in marketing by illustrating how the tourism industry may benefit from a perspective that considers the spiritual benefits of consumption. The research findings suggest that the intangible spiritual benefits of travel, in addition to the tangible benefits, should be highlighted in travel offers and tourism communications targeted to older adults. Copyright © 2014 John Wiley & Sons, Ltd.     

教养方式的母子感知差异与儿童抑郁的关系：母子依恋的中介作用

本研究以300个三至六年级双亲家庭中的儿童和母亲为研究对象,采用儿童版和家长版教养方式问卷、父母与同伴依恋问卷、流调中心抑郁量表,通过响应面分析法探讨了母子感知到的教养方式差异与儿童抑郁的关系,并使用标准分差法计算感知差异,通过结构方程模型分析了母子依恋是否在其中起到中介作用。研究发现:(1)母亲感知到的权威型、独裁型教养方式显著高于儿童感知,而纵容型教养方式则显著低于儿童;(2)权威型教养方式的母子感知差异正向线性预测儿童抑郁,独裁型教养方式的母子感知差异负向线性预测儿童抑郁,纵容型教养方式的感知差异对儿童抑郁没有显著预测作用;(3)母子依恋质量在权威型教养方式的母子感知差异和儿童抑郁之间起完全中介作用,但在独裁型教养方式的母子感知差异对儿童抑郁的预测中没有起到中介作用。