Molecular Tumor Boards: Ethical Issues in the New Era of Data Medicine

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine” (DM) (big data, data mining). The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision of care. Molecular tumor boards (MTB) are one response to these changes and are now providing better access to next-generation sequencing (NGS) and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent (IC) documents at all academic medical centers and to introduce dynamic and electronic informed consent (e-IC).     

Should DBS for Psychiatric Disorders be Considered a Form of Psychosurgery? Ethical and Legal Considerations

Deep brain stimulation (DBS), a surgical procedure involving the implantation of electrodes in the brain, has rekindled the medical community’s interest in psychosurgery. Whereas many researchers argue DBS is substantially different from psychosurgery, we argue psychiatric DBS—though a much more precise and refined treatment than its predecessors—is nevertheless a form of psychosurgery, which raises both old and new ethical and legal concerns that have not been given proper attention. Learning from the ethical and regulatory failures of older forms of psychosurgery can help shed light on how to address the regulatory gaps that exist currently in DBS research. To show why it is important to address the current regulatory gaps within psychiatric DBS, we draw on the motivations underlying the regulation of earlier forms of psychosurgery in the US. We begin by providing a brief history of psychosurgery and electrical brain stimulation in the US. Against this backdrop, we introduce psychiatric DBS, exploring current research and ongoing clinical trials. We then draw out the ethical and regulatory similarities between earlier forms of psychosurgery and psychiatric DBS. As we will show, the factors that motivated strict regulation of earlier psychosurgical procedures mirror concerns with psychiatric DBS today. We offer three recommendations for psychiatric DBS regulation, which echo earlier motivations for regulating psychosurgery, along with new considerations that reflect the novel technologies used in DBS.     

Why Frankenstein is a Stigma Among Scientists

As one of the best known science narratives about the consequences of creating life, Mary Shelley’s Frankenstein; or, The Modern Prometheus (1818) is an enduring tale that people know and understand with an almost instinctive familiarity. It has become a myth reflecting people’s ambivalent feelings about emerging science: they are curious about science, but they are also afraid of what science can do to them. In this essay, we argue that the Frankenstein myth has evolved into a stigma attached to scientists that focalizes the public’s as well as the scientific community’s negative reactions towards certain sciences and scientific practices. This stigma produces ambivalent reactions towards scientific artifacts and it leads to negative connotations because it implies that some sciences are dangerous and harmful. We argue that understanding the Frankenstein stigma can empower scientists by helping them revisit their own biases as well as responding effectively to people’s expectations for, and attitudes towards, scientists and scientific artifacts. Debunking the Frankenstein stigma could also allow scientists to reshape their professional identities so they can better show the public what ethical and moral values guide their research enterprises.     

Somatic Countertransference as Evidence of Adhesive Identification in a Severely Traumatized Woman

This paper discusses the use of somatic countertransference as a means of learning about the patient, about projective and adhesive identification and about the object relating nature of the most traumatized and withdrawn part of the personality. It assumes an elemental knowledge of British Object Relations and uses clinical material to illustrate the hypotheses that somatic countertransference is an indicator of a very elemental communication occurring from the aspect of the psyche that is united in a body mind or mind body. The paper assumes that this body mind was object seeking at birth and perhaps before. Because these early aspects of the personality are non verbal and non conceptual, the analyst must rely not only on the verbal material in a session but on the emotional and sensual experiences within the transference and the countertransference. Such reliance requires a faith in one’s own intuition without a certainty that one is “right.” Because speaking of such early experience is difficult, often writers and analysts appear more certain than they are. This is a hazard of this type of analytic work. What I am writing about is conjecture or imagination or dream, but I am suggesting that such dream work is a valuable tool for analysis.     

The Psychic Life of Fragments: Splitting from Ferenczi to Klein*

The present paper starts from the reflection that there is a curious “phenomenological gap” in psychoanalysis when it comes to processes of splitting and to describing the “life” of psychic fragments resulting from processes of splitting. In simpler terms, we are often in a position to lack a precise understanding of what is being split and how the splitting occurs. I argue that although Melanie Klein’s work is often engaged when talking of splitting (particularly through discussions on identification, projection and projective identification), there are some important phenomenological opacities in her construction. I show that by orchestrating a dialogue between Melanie Klein and Sándor Ferenczi, we arrive at a fuller and more substantive conception of psychic splitting and of the psychic life of fragments which are the result of splitting. This is even more meaningful because there are some unacknowledged genealogical connections between Ferenczian concepts and Kleinian concepts, which I here explore. While with Klein we remain in the domain of “good” and “bad” objects—polarised objects which are constantly split and projected—with Ferenczi we are able to also give an account of complicated forms of imitation producing psychic fragments and with a “dark” side of identification, which he calls “identification with the aggressor”. While attempting to take steps toward imagining a dialogue between Klein and Ferenczi, I note a certain silent “Ferenczian turn” in a late text by Melanie Klein, “On the Development of Mental Functioning”, written in 1958. In particular, I reflect on her reference to some “terrifying figures” of the psyche, which cannot be accounted for simply as the persecutory parts of the super-ego but are instead more adequately read as more enigmatic and more primitive psychic fragments, resulting from processes of splitting.     

“My iPhone Changed My Life”: How Digital Technologies Can Enable Women’s Consumption of Online Sexually Explicit Materials

Digital technologies continue to change the ways women can access and consume sexual materials online, including pornography. Yet, limited research has considered the possibilities of digital technologies to enhance women’s access and consumption of online pornographic materials. In this paper, we use a cyberfeminist lens to examine women’s experiences consuming online sexually explicit materials, which most women defined as pornography including videos and images. In particular, we consider the ways women who identify as porn consumers can use digital technologies to enable and enhance their consumption of these pornographic materials. Drawing on qualitative, in-depth interviews with 11 women, our findings illustrate the ways women can use digital technologies to consume pornography online in ways that help them to fulfill their sexual needs, embrace and explore their sexual selves, connect in sexual relationships, and normalize their sexual desires.     

Condom Use Among South African University Students in the Province of KwaZulu-Natal

South Africa has one of the highest HIV infection rates in the world, with young people particularly affected. Condoms are an effective preventative method against HIV among sexually active adults. This study assessed the level of condom usage among university students in South Africa and their attitudes towards condom usage, negotiation efficacy and confidence in condom usage. It was a cross-sectional study conducted amongst South African university students living at the university residences. Students were randomly selected and required to complete a self-administered questionnaire. The mean age of participants (n?=?441) was 22.7?±?4.3 years. The mean age of sexual debut was 17.7?±?3.0 years with 1.4?±?1.47 (range 0–13) current partners. Less than half of the students used a condom at sexual debut and only 28.5% used condoms during recent sexual activity. Those students who used a condom at first sexual intercourse had marginally more positive attitudes about condom usage than those who did not do so (p?=?0.056). Students with a single current partner had more positive attitudes about condom usage than those with multiple current partners (p?=?0.021). Only 32.5% (n?=?127) of the students were very confident in using condoms. Similarly, only 33.0% (n?=?130) of the participants felt that they could definitely negotiate condom use with their partners. We conclude that condom use among South African students is low and that they lack the confidence to use condoms. We recommend that programmes to step up condom use must also incorporate educational interventions on usage.     

The Interplay Between Trust Among Peers and Interpersonal Characteristics in Homophobic Bullying Among Italian Adolescents

This study is based on exploring the trust between peers and the individual characteristics related to homophobic bullying in adolescence. Participants were 334 adolescents (141 boys and 193 girls) aged from 15 to 20 years. Participants completed the homophobic bullying scale, to investigate bullying actions towards sexual minorities, the personal attributes questionnaire, for personal characteristics, and the inventory of parent and peer attachment, to the trust between peers. The results demonstrated how female participants manifested a higher level of interpersonal traits and trust among peers than boys. Results showed how a lack of trust between peers predicts homophobic bullying. Nevertheless, we found that the lack of interpersonal characteristics represents a variable that likely mediates the relationship between lack of trust in peers and homophobic bullying. Theoretical and practical implications are discussed.     

Mismatched Lovers: Exploring the Compatibility Between LGBTQ+ Identity Theories and Gender and Sexual Plurality in Sri Lanka

Sexual and gender identity development theories in psychology and sociology exert considerable influence over discourse on gender and sexuality, shaping key domains such as counseling, education, and social work, as well as public policy and advocacy. While a robust body of literature has developed in critique of such theories and models, they continue to be applied in the Global South without much thought for their relevance to various non-Western cultural contexts. The current study explores the fit of these identity development theories to the experiences of 15 non-heterosexual and transgender individuals in Sri Lanka, gathered through a qualitative study of the question in 2016. These participants articulated gender and sexual self-conceptions that were incongruent with major identity development theories in significant ways. A broad majority failed to endorse central or salient sexual identities, while demonstrating a fluidity in object choice, sex roles, and sex acts, thus rupturing the theoretical notion of stable and coherent identities. Transgender participants did not demonstrate identity synthesis or pride and complicated theoretical understandings of sexual intimacy. These findings highlight the necessity of considering individual differences and cultural contexts when studying gender and sexuality and the dangers of universalizing theories across cultural differences.