Reactivated memory of an inhibitory avoidance response in mice is sensitive to a nitric oxide synthase inhibitor

It is accepted that once consolidation is completed memory becomes permanent. However, it has also been suggested that reactivation (retrieval) of the original memory, again, makes it sensitive to the same treatments that affect memory consolidation when given after training. Previous results demonstrated that the immediate post-training intraperitoneal administration of N^ω-nitro-l-arginine methyl ester (L-NAME), a non-specific inhibitor of nitric oxide synthase (NOS), impairs retention test performance of a one-trial step-through inhibitory avoidance response in adult mice. The effect of L-NAME on retention was attributed to an action on memory consolidation of the original learning. For the first time, we report that the administration of L-NAME after the first retention test (memory reactivation) of the inhibitory avoidance response impairs retention performance over six consecutive days. This impairment effect is dose-and-time dependent and could not be attributed to a retrieval deficit since a mild footshock did not reinstate the original avoidance response and no spontaneous recovery was observed at least 21 days after training. Further support for a storage deficit interpretation as opposed to a retrieval deficit was obtained from the fact that L-NAME’s effects after retrieval were not due to state-dependency. The impairment effect of L-NAME was dependent on the age of the original memory. That is, there was an inverse correlation between the susceptibility of the memory trace when reactivated and the time elapsed between training and the first retrieval session. We suggest an action of L-NAME on memory reactivation-induced processes that are different from memory extinction of the original learning extending the biological significance of nitric oxide on memory.     

Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Preliminary Australian normative data

The aim of the present study was to establish demographically adjusted normative data for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) in an Australian context. RBANS data from 172 healthy Australian community dwelling adults enrolled in the “Using our Brains” (UoB) Brain Tissue Donor program between April 2002 and September 2005 were included in this study. The present study group differed from the original North American normative sample on all 12 subtests and five RBANS indices. Education and to a lesser degree age were related to RBANS performance. The present study provides complementary RBANS normative data for clinicians and researchers when interpreting RBANS results for Australian individuals closely matching those reported in this study.     

Jung in Africa: the historical record

Blake Burleson's ninety-minute presentation was part one of 'A Passage to Africa' moderated by John Beebe. Eight individual filmed sequences from home movies taken by Helton Godwin Baynes during Jung's 1925 expedition to East Africa were shown. In addition to placing these clips in their historical, geographic, and cultural context, Burleson introduced the following cultural complexes revealed in the film and in travelling companion Ruth Bailey's commentary on the film: romantic primitivism, 'going black', self-conscious élite, 'furor Africanus', the 'black man's burden', racial inferiority, and the 'curse of Ham'.     

The efficiency of biological motion perception

Humans can readily perceive biological motion from point-light (PL) animations, which create an image of a moving human figure by tracing the trajectories of a small number of light points affixed to a moving human body. We have applied ideal observer analysis to a standard biological motion discrimination task involving either full-figure or PL displays. Contrary to current dogma, we find that PL animations can be rich inpotential stimulus information but that human observers are remarkably inefficient at exploiting this information. Although our findings do not discount the utility of PL animation, they do provide a realistic measure of the computational challenge posed by biological motion perception.     

The Moral Deliberations of 15 Clergy on Suicide and Assisted Death: A Qualitative Study

Given the relationship between moral objections to suicide, physician-assisted suicide (PAS), and euthanasia and religion, it is important to understand under what conditions clergy have moral objections to suicide, ending futile medical treatment, PAS, and euthanasia. This study used thematic analysis to explore the moral deliberations of 15 clergy and the right- and wrong-making properties of nine death and dying scenarios. Fifteen Catholic, Jewish, and Protestant clergy completed semi-structured interviews. Data analysis generated eight themes: sanctity of life, preservation of the natural course of life, pastoral care, support of the faith community, referral to professional services, end-of-life decision in community, consultation with medical professionals, and a shift to a hopeful narrative. Respondents consistently endorsed the priority of pastoral care, demonstrating a deep concern for the well-being of suffering congregants. In conclusion, respondents were consistent in the application of eight themes to end-of-life scenarios but differed in their approach to the removal of a feeding tube and being present for a PAS death. Every respondent objected to suicide.     

Early representations of ownership

To navigate a world filled with private property, children must be able to assign ownership information to objects and update that information when appropriate. In this chapter, the authors propose that children include ownership as an attribute of their object representations. Children can learn about ownership attributes either by witnessing owners acting on their property, a visual source, or by receiving information from the testimony of others, a verbal source. The authors consider the differences between these two forms of information and how they might conflict at the representational level, leading to difficulties in learning about ownership.     

Transdiagnostic internet treatment for anxiety and depression: a randomised controlled trial

Disorder-specific cognitive behavioural therapy programs delivered over the internet (iCBT) with clinician guidance are effective at treating specific anxiety disorders and depression. The present study examined the efficacy of a transdiagnostic iCBT protocol to treat three anxiety disorders and/or depression within the same program (the Wellbeing Program). Seventy-seven individuals with a principal diagnosis of major depression, generalised anxiety disorder, panic disorder, and/or social phobia were randomly assigned to a Treatment or Waitlist Control group. Treatment consisted of CBT-based online educational lessons and homework assignments, weekly email or telephone contact from a clinical psychologist, access to a moderated online discussion forum, and automated emails. Eighty one percent of Treatment group participants completed all 8 lessons within the 10 week program. Post-treatment data were collected from 34/37 Treatment group and 35/37 Control group participants, and 3-month follow-up data were collected from 32/37 Treatment group participants. Relative to Controls, Treatment group participants reported significantly reduced symptoms of anxiety and depression as measured by the Depression Anxiety and Stress Scales-21 item, Patient Health Questionnaire-9 item, and Generalised Anxiety Disorder-7 item scales, with corresponding between-groups effect sizes (Cohen’s d) at post treatment of.56,.58, and.52, respectively. The clinician spent a mean time of 84.76 min (SD = 50.37) per person over the program. Participants rated the procedure as highly acceptable, and gains were sustained at follow-up. These results provide preliminary support for the efficacy of transdiagnostic iCBT in the treatment of anxiety and depressive disorders.     

Choosing job-related personality traits: Developing valid personality-oriented job analysis

Although personality assessment has proven utility in pre-employment testing, little is known about how one should choose the personality traits that are most job-related. We developed a Personality-oriented Job Analysis (POJA) process for choosing job-related personality traits. We evaluated this process using 15 expert raters and approximately 330 medical students who each completed six different “jobs” in which their performance was evaluated. There was consistency across experts in POJA ratings of the job-relevance of personality traits. Also, POJA ratings of the personality traits correlated with the actual criterion-validity of the traits. Traits that received the highest POJA ratings tended to predict job performance. To our knowledge, this is the first published work to present evidence of the criterion-validity of POJA.     

To Know and Be Known: An Intimacy‐Based Explanation for the Gender Gap in Biblical Literalism

We assess the gender gap in U.S. Christianity by examining in a national sample (Baylor Religion Survey 2010) a particularly robust measure of religiosity: biblical literalism. Women are more likely to report biblical literalism than men in bivariate comparisons, but we argue that intimate attachment to God is a related intervening mechanism. The results of this study indicate: (1) intimate attachment to God is associated with more literal views of the Bible, (2) after accounting for attachment to God women are no longer associated with increased literalism, (3) divine proximity‐seeking behaviors are associated with more literal views of the Bible, (4) proximity‐seeking moderates the relationship between attachment to God and Bible views, and (5) gender moderates the relationship between both attachment to God and proximity‐seeking behaviors and Bible views. The evidence presented here provides a plausible mechanism by which gender differences in biblical literalism may be accounted for.