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31.
Blair RJ 《Brain and cognition》2004,55(1):198-208
This article considers potential roles of orbital frontal cortex in the modulation of antisocial behavior. Two forms of aggression are distinguished: reactive aggression elicited in response to frustration/threat and goal directed, instrumental aggression. It is suggested that orbital frontal cortex is directly involved in the modulation of reactive aggression. It is argued that orbital frontal cortex does not "inhibit" reactive aggression but rather may both increase or decrease its probability as a function of social cues present in the environment. Early dysfunction in this function of orbital frontal cortex may be linked to the development of Borderline Personality Disorder. Instrumental aggression is linked to a fundamental failure in moral socialization. However, the available data suggest that the amygdala, but not orbital frontal cortex, is required for functions such as aversive conditioning and passive avoidance learning that are necessary for moral socialization. Psychopathic individuals who present with significant instrumental aggression, are impaired in aversive conditioning and passive avoidance learning and show evidence of amygdala dysfunction. Orbital frontal cortex and the amygdala are involved in response reversal where instrumental responses must be reversed following contingency change. Impairments in response reversal are also seen in psychopathic individuals. However, it remains unclear whether impairment in response reversal per se is associated with antisocial behavior. 相似文献
32.
Robertson JA 《The American journal of bioethics : AJOB》2004,4(3):32-3; discussion W23-31
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Rats were exposed to the compound flavors AX and BX, presented in alternation, and to CX on a separate block of trials. Generalization to BX after aversion conditioning with AX was less than to CX. An equivalent effect was found when the nature of the common element was changed after preexposure but not when the common element was omitted during preexposure, during conditioning and test, or both. Rats conditioned with X alone again showed less aversion to BX than to CX; similarly, rats conditioned with a novel flavor (Y) showed less aversion to BY than to CY. These effects support the proposal that intermixed preexposure to AX and BX enhances the perceptual effectiveness of their unique features, A and B. 相似文献
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36.
Blair HT Schafe GE Bauer EP Rodrigues SM LeDoux JE 《Learning & memory (Cold Spring Harbor, N.Y.)》2001,8(5):229-242
Fear conditioning is a form of associative learning in which subjects come to express defense responses to a neutral conditioned stimulus (CS) that is paired with an aversive unconditioned stimulus (US). Considerable evidence suggests that critical neural changes mediating the CS-US association occur in the lateral nucleus of the amygdala (LA). Further, recent studies show that associative long-term potentiation (LTP) occurs in pathways that transmit the CS to LA, and that drugs that interfere with this LTP also disrupt behavioral fear conditioning when infused into the LA, suggesting that associative LTP in LA might be a mechanism for storing memories of the CS-US association. Here, we develop a detailed cellular hypothesis to explain how neural responses to the CS and US in LA could induce LTP-like changes that store memories during fear conditioning. Specifically, we propose that the CS evokes EPSPs at sensory input synapses onto LA pyramidal neurons, and that the US strongly depolarizes these same LA neurons. This depolarization, in turn, causes calcium influx through NMDA receptors (NMDARs) and also causes the LA neuron to fire action potentials. The action potentials then back-propagate into the dendrites, where they collide with CS-evoked EPSPs, resulting in calcium entry through voltage-gated calcium channels (VGCCs). Although calcium entry through NMDARs is sufficient to induce synaptic changes that support short-term fear memory, calcium entry through both NMDARs and VGCCs is required to initiate the molecular processes that consolidate synaptic changes into a long-term memory. 相似文献
37.
Formal models of categorization make different predictions about the theoretical importance of linear separability. Prior research, most of which has failed to find support for a linear separability constraint on category learning, has been conducted using tasks that involve learning two categories with a small number of members. The present experiment used four categories with three or nine patterns per category that were either linearly separable or not linearly separable. With overall category structure equivalent across category types, the linearly separable categories were found to be easier to learn than the not linearly separable categories. An analysis of individual participants' data showed that there were more participants operating under a linear separability constraint when learning large categories than when learning small ones. Formal modeling showed that an exemplar model could not account for many of these data. These results are taken to support the existence of multiple processes in categorization. 相似文献
38.
Rehabilitation of the damaged brain can foster reconnection of damaged neural circuits; Hebbian learning mechanisms play an important part in this. The authors propose a triage of post-lesion states, depending on the loss of connectivity in particular circuits. A small loss of connectivity will tend to lead to autonomous recovery, whereas a major loss of connectivity will lead to permanent loss of function; for such individuals, a compensatory approach to recovery is required. The third group have potentially rescuable lesioned circuits, but guided recovery depends on providing precisely targeted bottom-up and top-down inputs, maintaining adequate levels of arousal, and avoiding activation of competitor circuits that may suppress activity in target circuits. Empirical data are implemented in a neural network model, and clinical recommendations for the practice of rehabilitation following brain damage are made. 相似文献
39.
Correlations for timing consistency among tapping and drawing tasks: evidence against a single timing process for motor control. 总被引:6,自引:0,他引:6
S D Robertson H N Zelaznik D A Lantero K G Bojczyk R M Spencer J G Doffin T Schneidt 《Journal of experimental psychology. Human perception and performance》1999,25(5):1316-1330
Three experiments were conducted to examine whether timing processes can be shared by continuous tapping and drawing tasks. In all 3 experiments, temporal precision in tapping was not related to temporal precision in continuous drawing. There were modest correlations among the tapping tasks, and there were significant correlations among the drawing tasks. In Experiment 3, the function relating timing variance to the square of the observed movement duration for tapping was different from that for drawing. The conclusions drawn were that timing is not an ability to be shared by a variety of tasks but instead that the temporal qualities of skilled movement are the result of the specific processes necessary to produce a trajectory. These results are consistent with the idea that timing is an emergent property of movement. 相似文献
40.
Randall T. Salekin Henrik Andershed Blair D. Batky Andrew P. Bontemps 《Journal of psychopathology and behavioral assessment》2018,40(1):1-5
A guiding question for this special section, sparked by the increasing number of studies on callous –unemotional traits (CU traits) and the DSM-5 Limited Prosocial Emotion (LPE) specifier, is whether CU traits are enough to identify a clinically meaningful subgroup of youth with conduct problems or whether other psychopathic traits contribute. Seven empirical papers and two commentary papers address this question to varying degrees and in different ways with some papers “competing” various models against one another along with other papers investigating distinct correlates of the psychopathy factors. Findings across the papers suggest that there could be benefits to examining the broader construct of psychopathy in addition to examining its underpinning dimensions rather than CU traits alone. Two commentary papers also shed light on the importance of psychopathic traits in children with Conduct Disorder (CD) and provide insights for future work on this topic. It is hoped that the articles and commentary will generate new ideas for research and practice that could have implications for the treatment of those individuals with CD and psychopathic traits. 相似文献