Fixed-interval limited-hold avoidance with and without signalled reinforcement

Rats trained to lever press on a fixed-interval limited-hold avoidance schedule maintained a pattern of responding similar to that maintained by fixed-interval limited-hold schedules of positive reinforcement. But this positively accelerated pattern of behavior was maintained only when the occurrence of reinforcement was signalled by the presentation of a brief flash of light. This result suggests that the discriminative function of the reinforcer in avoidance is less pronounced than the discriminative function of the reinforcer in escape or positive reinforcement. It also suggests that the distinction between positive reinforcement and avoidance is not superfluous. Although the schedule of reinforcement is an important variable in determining the pattern of behavior, other variables, such as the nature (i.e., stimulus presentation, termination, or omission) of the reinforcer, are also potent determinants of behavior.     

A suit for protecting chronically implanted devices in monkeys

The plastic barrel suit provides complete protection of chronically implanted fistulas and electrical connectors. The lost time, expense, and the frustrations of having these devices damaged was avoided.     

Experimental design symbolization and model derivation

A method of design symbolization (DS) is given for a class of designs in which all factors are related by complete crossing or by nesting. Characterization of acceptable DS's, and logical relational properties are given. It is shown how the design model can be obtained from the DS.The preparation of this article was supported by NIH Grant GM-11128, and by grants to the Institute of Human Learning by NSF and NIH.     

The 3RT Test: Three reaction time tasks for IBM PC computers

The 3RT Test consists of a simple, a choice, and a conditional reaction time (RT) task. The three tasks involve comparable visual stimuli and require identical manual responses, but they differ in the complexity of cognitive processing required. The nonverbal stimuli convey commonly known meanings. Responses can be made either on the keyboard or on response keys connected to the computer’s serial port. The computer’s internal timer/counter is used for millisecond timing. The test administration program allows flexible setting of the test conditions. The data analysis program provides summary data not only for each RT task as a whole, but also for separate trial types within each task. Summary statistics include measures of variation and central value that are not affected by extreme scores. In addition to laboratory studies with normal adults, the 3RT Test is suitable for life-span developmental studies, cross-cultural comparisons, and other uses in various clinical settings.     

Potentiation of the pressor response to stress by tolbutamide in dogs

Tolbutamide has previously been shown to amplify the pressor effects of “exogenous” catecholamines in conscious dogs, possibly due to sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. The objective of this study was to examine if tolbutamide also amplifies the pressor effects of “endogenous” catecholamines released during psychological stress (classical Pavlovian aversive conditioning). Experiments were conducted in β-adrenoreceptor-blocked (propranolol, 1 mg/kg, i.v.) conscious dogs (n=4) trained in classical aversive conditioning. Conditioning was accomplished by following a tone (CS+) with a 1/2 second shock; another tone (CS-) was not followed by any shock and served as control. With saline pretreatment, aversive conditioning (i.e., CS+) increased mean arterial pressure (MAP) only by approximately 4.7% when compared to CS-, whereas with tolbutamide (45 mg/kg, i.v.) pretreatment, the increase in MAP induced by CS+ beyond what was induced by the CS- (approximately 6.2%) was significantly (p<0.05) larger than that with saline pretreatment. In isolated canine femoral arterial segments (n=4), the vasoconstrictor effect of phenylephrine (an α₁-agonist) at 5×10^?6M (which was the EC₅₀ value) was amplified by 2×10^?2M of tolbutamide from 54.0±2.0% to 66.9±2.1%. In conclusion, tolbutamide amplifies the pressor effects of “endogenous” catecholamines in conscious dogs, possibly by sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. This mechanism of action is novel and has not been reported with other agents.     

Some hypotheses concerning the evolution of polysemous words

The evolution of polysemous words is examined in three studies. Study 1 indicates that older words are more polysemous than recent words, and that frequently used words are more polysemous than infrequently used words. These effects were replicated, controlling for word concreteness (Study 2) and evaluation (Study 3), using two other samples of words. If words evolve additional meanings through metaphor (MacCormac, 1985), then variables (such as concreteness and evaluation) that play a role in metaphor may mediate the evolution of polysemy. The correlation between concreteness and polysemy was negligible (Study 2). As hypothesized, evaluation is a significant predictor of polysemy: Negative words are more polysemous than positive words, and relatively neutral words are more polysemous than evaluatively extreme words. These findings are consistent with the notion that polysemous words evolve, in part, through metaphor.