Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams

Gestational cocaine treatment results in significantly increased maternal aggression towards an intruder by postpartum day six, while acute postpartum treatment dose dependently decreases maternal aggressive (MA) behavior. Both increased and decreased aggression in the cocaine-treated dams are correlated with either decreased or increased levels of oxytocin in the amygdala, respectively. The current study was an effort to determine whether the effect of gestational cocaine on maternal aggression is transient or would continue into the postpartum period; whether an intermittent cocaine treatment regimen, which incorporates gestational and postpartum intermittent cocaine treatment, would differ from chronic daily gestational treatment; and finally, whether next generation female offspring of cocaine-treated or control dams would have altered MA behavior and oxytocin system changes attributable to either prenatal drug exposure, rearing condition or both. We now report no increase in maternal aggression following chronic gestational treatment and significantly lower levels of aggression in intermittently treated dams on postpartum day eight, with no significant effects in either group on postpartum day 12. Young adult female offspring of the cocaine-treated and control dams, who reared their own natural litters and were tested on postpartum day eight for maternal aggression, had higher levels of maternal aggression towards an intruder attributable to both prenatal cocaine exposure and rearing condition. Higher aggression in cocaine-reared next generation dams was associated with lower levels of oxytocin in the amygdala. Intergenerational effects of cocaine were apparent with respect to aggression and oxytocin system changes.     

Electoral Politics and Immigration in Canada: How Does Immigration Matter?

The conventional wisdom about the relationship between immigration and national electoral politics in Canada, albeit based on limited research, is that immigration is non-partisan and does not feature prominently during election campaigns. This paper examines the last two federal elections, in 2004 and 2006, employing a multi-pronged approach to party platform, media and survey analysis, in order to determine if immigration is discussed and, if so, how. It finds a political debate does take place but is not easily discernible using traditional research methods. This discourse is framed in terms of alternatives of inclusion, and not exclusion, something facilitated by the complexity of the Canadian immigration programme and the geographical and political landscape, and appears to be especially evident during more competitive elections.     

Malingering in toxic exposure: classification accuracy of reliable digit span and WAIS-III Digit Span scaled scores

This study examined the sensitivity and false-positive error rate of reliable digit span (RDS) and the WAIS-III Digit Span (DS) scaled score in persons alleging toxic exposure and determined whether error rates differed from published rates in traumatic brain injury (TBI) and chronic pain (CP). Data were obtained from the files of 123 persons referred for neuropsychological evaluation related to alleged exposure to environmental and industrial substances. Malingering status was determined using the criteria of Slick, Sherman, and Iverson (1999). The sensitivity and specificity of RDS and DS in toxic exposure are consistent with those observed in TBI and CP. These findings support the use of these malingering indicators in cases of alleged toxic exposure and suggest that the classification accuracy data of indicators derived from studies of TBI patients may also be validly applied to cases of alleged toxic exposure.     

A Model-Based Approach to Understanding Apraxia in Corticobasal Syndrome

Limb apraxia is a neurological disorder of higher cognitive function characterized by an inability to perform purposeful skilled movements and not attributable to an elementary sensorimotor dysfunction or comprehension difficulty. Corticobasal Syndrome (CBS) is an akinetic rigid syndrome with asymmetric onset and progression with at least one basal ganglia feature (rigidity, limb dystonia or myoclonus) and one cortical feature (limb apraxia, alien hand syndrome or cortical sensory loss). Even though limb apraxia is highly prevalent in CBS (70–80%), very few studies have examined the performance of CBS patients on praxis measures in detail. This review aims to (1) briefly summarize the clinical, neuroanatomical and pathological findings in CBS, (2) briefly outline what limb apraxia is and how it is assessed, (3) to comprehensively review the literature on limb apraxia in CBS to date and (4) to briefly summarize the literature on other forms of apraxia, such as limb-kinetic apraxia and buccofacial apraxia. Overall, the goal of the review is to bring a model-based perspective to the findings available in the literature to date on limb apraxia in CBS.     

Differences that suggest female investment in,and male distance from,children

A factorial between subjects experiment was conducted with sex of respondent, level of success, sex of stimulus parent, and sex of stimulus child as the independent variables. Two hundred seventy-two undergraduates without parenting experience constituted the sample. The attributions made to explain parenting success/failure and the ratings made both of the child and the parent on the same 60 personality item were the dependent variables. Female respondents were not only especially success-oriented, but evidenced a view of parenting emphasizing deliberation and skill, whereas their male counterparts were comparatively more inclined to explain failure in terms of it being the child's fault and to overstate a child's meanness.This investigation was completed on the first author's NIMH traineeship (5 T01 MH-14473) for doctoral study. The authors are appreciative of the contributions of Professors Donn Byrne, Kay Deaux, and William Martin to the development of this study.