MMPI-2 validity scale characteristics in a correctional sample

The current study investigated the proportion of content-nonresponsive and content-responsive faking Minnesota Multiphasic Personality Inventory-2 (MMPI-2) protocols in a state corrections sample. Participants were 51,486 inmates who completed the MMPI-2 at the time they entered the Ohio Department of Rehabilitation and Correction system. Overall, approximately 79% of the study participants produced valid profiles. Of the entire study sample, 11.3% produced content-nonresponsive profiles, and 9.4% produced content-responsive faking profiles. African Americans produced a higher proportion of content-nonresponsive profiles than Caucasians, and women were slightly more likely than men to produce content-responsive faking profiles. Differences in level of education between African Americans and Caucasians did not account for the disparity in content-nonresponsive profiles. Implications for current practice and future research are discussed.     

Blockade of NR2B-Containing NMDA Receptors Prevents BDNF Enhancement of Glutamatergic Transmission in Hippocampal Neurons

Application of brain-derived neurotrophic factor (BDNF) to hippocampal neurons has profound effects on glutamatergic synaptic transmission. Both pre- and postsynaptic actions have been identified that depend on the age and type of preparation. To understand the nature of this diversity, we have begun to examine the mechanisms of BDNF action in cultured dissociated embryonic hippocampal neurons. Whole-cell patch-clamp recording during iontophoretic application of glutamate revealed that BDNF doubled the amplitude of induced inward current. Coexposure to BDNF and the NMDA receptor antagonist AP-5 markedly reduced, but did not entirely prevent, the increase in current. Coexposure to BDNF and ifenprodil, an NR2B subunit antagonist, reproduced the response observed with AP-5, suggesting BDNF primarily enhanced activity of NR2B-containing NMDA receptors with a lesser effect on non-NMDA receptors. Protein kinase involvement was confirmed with the broad spectrum inhibitor staurosporine, which prevented the response to BDNF. PKCI19-31 and H-89, selective antagonists of PKC and PKA, had no effect on the response to BDNF, whereas autocamtide-2-related inhibitory peptide, an antagonist of CaM kinase II, reduced response magnitude by 60%. These results demonstrate the predominant role of a specific NMDA receptor subtype in BDNF modulation of hippocampal synaptic transmission.     

MESA: A portable multi-energy sensor array for low-frequency electromagnetic field fluctuations

The study of the relation between electromagnetic fields and various psychological phenomena would be enhanced by the measurement and correlation of time series over multiple energy bands. The paper discusses the design and implementation of a computerized multi-energy sensor array (MESA) that detects and records low-frequency energy fluctuations. The current implementation of MESA focuses on the measurement of magnetic fields, infrared and visible light frequencies, and indices of seismic activity. However, MESA is sufficiently flexible to accommodate the measurement of other variables as well, and it can be configured to suit applications in laboratory and field settings.     

Smooth pursuit eye movements in normal and dyslexic children

This paper describes a detailed study of horizontal eye movements associated with visual tracking of a smoothly moving target. Essentially all children, even at target velocities as low as 5 degrees/sec., show some saccadic eye movements superimposed on smooth tracking movements. Detailed analysis of pursuit eye-movements from a group of 26 poor readers and 34 normal controls (8 to 13 yr.) showed that about 25% of poor readers have an abnormally raised saccadic component in smooth pursuit. This suggests that studies of eye movements during tracking of smoothly moving targets at low velocity, combined with a quantitative approach to data analysis, may be useful for early detection of a significant proportion of poor-reading children.     

Clues to aural discrimination

Five measures of the items of the Multiple-Choice Intelligibility Test were obtained: apparent aural similarity of the four words available to a listener on hearing a stimulus, interconsonantal differences among the prevocalic portions of these words, phonemic discrepancies among these words, distinctive feature differences among these words, and the pooled discrimination score of the four words that were available to the responder on hearing the stimulus. The last score was made the target in a multiple correlation problem, and the relative contribution, combined and separately, of the four remaining measures to the target measure was determined. These four measures accounted for approximately 45% of the variance among the scores of discrimination. The strongest contributors were apparent aural similarity of the available responses and the phonemic discrepancy among the available responses.     

Screening for apraxia: a short assessment for stroke patients

Apraxia is a disorder that involves impaired ability to execute previously learned movements that cannot be attributed to basic sensory or motor disturbances. A thorough assessment of apraxia typically entails both pantomiming and imitation of transitive (tool-related), intransitive (communication-related), and meaningless gestures, presented in an array of different, process-dependent sensory conditions. Precise and detailed assessment tools are often time-consuming and a shorter screening tool may be desirable for efficient surveillance of this disorder in stroke patients. In the present study, stroke patients (N = 37) were compared to healthy controls (N = 30) in their production of commonly used transitive and intransitive gestures. Five gestures (knife, flipper, tweezers, okay sign, cab hailing) were consistently performed with poorer accuracy in stroke patients when compared to healthy controls. The combination of gestures that best captured apraxic performance was statistically determined based on Z-score data. Results provide a shortened and sensitive method of detecting apraxia in stroke patients.     

A Pilot Study of a Mental Silence Form of Meditation for Women in Perimenopause

Menopausal symptoms often feature or are worsened by psychological and psychosomatic factors. As there is limited research into the potential role of psychological interventions, especially meditation, for the treatment of these symptoms the current study adopted an AB case series design with a follow-up phase. Fourteen women who were experiencing hot flashes and other menopausal symptoms and receiving no treatment for them attended meditation classes twice weekly for 8 weeks and practiced daily at home. A mental silence orientated technique of meditation called Sahaja Yoga (SYM) was taught. The Hot Flash Diary, Kupperman Index, MENQOL, Greene’s Climacteric Scale and STAI, were administered at baseline, mid treatment (4 weeks), post-treatment (8 weeks) and at 8 weeks follow-up. Substantial improvements in all measures occurred at post treatment. Changes in vasomotor symptoms, especially hot flashes, were most prominent as a significant decrease of 67% at post-treatment and 57% at follow-up (χ² = 11.7, p < .003) were noted and Kupperman’s Index score decreased by 58% at post-treatment and 40% at follow-up (χ² = 11.7, p < .005). All other symptom measures improved substantially from baseline to post-treatment, non-parametric analysis indicating that most of these changes were significant. These findings tentatively suggest that menopausal symptoms, especially vasomotor symptoms, and particularly hot flashes, might be substantially improved by using meditation.