The effects of violence on infants and young children: international perspectives on prevention

People become subject to political and social violence when governments fail to give priority to basic health care or education. Attempts to meet foreign obligations also produce severe economic recessions which further impede efforts to improve the general quality of life of disadvantaged populations. Since multiple factors contribute to violence, a multidisciplinary approach is best suited to address the problem. For example, poverty and its associated risks are linked to violence, but living in poverty does not necessarily engender violence. Living in poverty may, however, fuel high rates of child mortality, illiteracy, malnutrition, excessive population growth, street children, and familial disintegration. An integrated action program was developed in Brazil for at-risk individuals and their families based upon the idea of building and reinforcing family ties and intergenerational togetherness. Undernourished infants, street children, the handicapped, women subjected to violence, and neglected senior citizens received special interventions in the program described in the text.     

Self-Monitoring negative statements

We examined the effects of a self-monitoring program on reducing the frequency of negative statements of a student with mild mental retardation who was enrolled in a self-contained classroom at a middle school. A changing criterion design was used within a multiple baseline design across two classroom periods. Additionally, the frequency of positive statements was reported. The results showed a decrease in the number of negative statements, and an increase in the number of positive statements. Maintenance data collected up to 8 weeks after the program ended indicated that the student continued to emit positive rather than negative statements. The use of this procedure to decelerate undesirable behavior is discussed.     

Offering predictive testing for Huntington disease in a medical genetics clinic: Practical applications

Predictive testing for Huntington disease is presently offered in a select few medical genetics centers in the United States. This is in part due to the labor intensive counseling and psychological testing suggested by the research protocols. We discuss some specific suggestions for establishing programs for Huntington disease predictive testing within pre-existing medical genetics clinics to encourage more centers to offer presymptomatic testing. This will allow more at risk individuals the opportunity to consider predictive testing and cut down the expenses of traveling to the few predictive testing centers that currently exist. The counseling principals will remain similar to those discussed here, even following the identification of the Huntington disease mutation.     

Potentiation of the pressor response to stress by tolbutamide in dogs

Tolbutamide has previously been shown to amplify the pressor effects of “exogenous” catecholamines in conscious dogs, possibly due to sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. The objective of this study was to examine if tolbutamide also amplifies the pressor effects of “endogenous” catecholamines released during psychological stress (classical Pavlovian aversive conditioning). Experiments were conducted in β-adrenoreceptor-blocked (propranolol, 1 mg/kg, i.v.) conscious dogs (n=4) trained in classical aversive conditioning. Conditioning was accomplished by following a tone (CS+) with a 1/2 second shock; another tone (CS-) was not followed by any shock and served as control. With saline pretreatment, aversive conditioning (i.e., CS+) increased mean arterial pressure (MAP) only by approximately 4.7% when compared to CS-, whereas with tolbutamide (45 mg/kg, i.v.) pretreatment, the increase in MAP induced by CS+ beyond what was induced by the CS- (approximately 6.2%) was significantly (p<0.05) larger than that with saline pretreatment. In isolated canine femoral arterial segments (n=4), the vasoconstrictor effect of phenylephrine (an α₁-agonist) at 5×10^?6M (which was the EC₅₀ value) was amplified by 2×10^?2M of tolbutamide from 54.0±2.0% to 66.9±2.1%. In conclusion, tolbutamide amplifies the pressor effects of “endogenous” catecholamines in conscious dogs, possibly by sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. This mechanism of action is novel and has not been reported with other agents.     

Shape from stereo: A systematic approach using quadratic surfaces

We used quadratic shapes in several psychophysical shape-from-stereo tasks. The shapes were elegantly represented in a 2-D parameter space by the scale-independentshape index and the scale-dependentcurvedness. Using random-dot stereograms to depict the surfaces, we found that the shape of hyperbolic surfaces is slightly more difficult to recognize than the shape of elliptic surfaces. We found that curvedness (and indirectly, scale) has little or no influence on shape recognition.