Learning strategy selection in the water maze and hippocampal CREB phosphorylation differ in two inbred strains of mice

Learning strategy selection was assessed in two different inbred strains of mice, C57BL/6 and DBA/2, which are used for developing genetically modified mouse models. Male mice received a training protocol in a water maze using alternating blocks of visible and hidden platform trials, during which mice escaped to a single location. After training, mice were required to choose between the spatial location where the platform had been during training (a place strategy) and a visible platform presented in a new location (a cued/response strategy). Both strains of mice had similar escape performance on the visible and hidden platform trials during training. However, in the strategy preference test, C57BL/6 mice selected a place strategy significantly more often than DBA/2 mice. Because much evidence implicates the hippocampus and striatum as important neural substrates for spatial/place and cued/response learning, respectively, the engagement of the hippocampus was then assessed after either place or cue training by determining levels of cAMP response element-binding protein (CREB) and phosphorylated CREB (pCREB) in these two mouse strains. Results revealed that hippocampal CREB levels in both strains of mice were significantly increased after place in comparison to cued training. However, the relation of hippocampal pCREB levels to training was strain dependent; pCREB was significantly higher in C57BL/6 mice than in DBA/2 mice after place training, while hippocampal pCREB levels did not differ between strains after cued training. These findings indicate that pCREB, specifically associated with place/spatial training, is closely tied to differences in spatial/place strategy preference between C57BL/6 and DBA/2 mice.     

Statistical processing: not so implausible after all

Myczek and Simons (2008) have shown that findings attributed to a statistical mode of perceptual processing can, instead, be explained by focused attention to samples of just a few items. Some new findings raise questions about this claim. (1) Participants, given conditions that would require different focused attention strategies, did no worse when the conditions were randomly mixed than when they were blocked. (2) Participants were significantly worse at estimating the mean size when given small samples than when given the whole display. (3) One plausible suggested strategy--comparing the largest item in each display, rather than the mean size--was not, in fact, used. Distributed attention to sets of similar stimuli, enabling a statistical-processing mode, provides a coherent account of these and other phenomena.     

Applying the Lifestyle Routine Activities Theory to Understand Physical and Nonphysical Peer Victimization

Peer victimization is a serious problem, and understanding where, with whom, and how long victims spend their time is important. Applying the lifestyle routine activities theory (LRAT), this study examines the association between 4 components of LRAT and physical and nonphysical peer victimization. Using the 2007 National Crime Victimization Survey, we examined Poisson and negative binomial regression models to explain whether physical and nonphysical peer victimization was affected by measures of routine activities. Our findings indicate that students’ exposure and proximity to motivated offenders, school environment, capable guardianship, and target attractiveness were associated with risk of peer victimization. Findings also reveal that risk factors varied depending on the type of victimization.     

The role of negative publicity in consumer evaluations of sports stars and their sponsors

This paper aims to specify and test empirically the impact that two types of negative information (immorality and incompetence) about a sports star have on consumers' perceptions of the sports star and the sponsor. The moderating role of game relevance (game‐related and non‐game‐related) and fan identification with a sports star (high identification and low identification) are also investigated. Using a sample of South Korean consumers (n = 249), we found in the experiment that the type of negative information affects participants' attitudes toward the sports star and the sponsor. This result implies that a sports star's involvement in negative events not only damages the star's reputation but also detracts from the value of the sponsor company. The results also show that the two factors moderate the main effects of negative publicity on consumers' perception of the sports star and his or her sponsor. First, the negative publicity about the sports star's functional issues (e.g., a career‐threatening injury) negatively affects consumer attitude toward the sports star and the sponsor more in the out‐of‐game context than in the in‐game situation. Second, bad sports star publicity has a greater negative effect on consumer perception of sponsors for lowly identified than highly identified sports stars, while the moderating effect on consumer perception of the sports star is not significant. Detailed practical implications and academic contributions are discussed. Copyright © 2017 John Wiley & Sons, Ltd.     

A comparative study on the flow experience in web-based and text-based interaction environments

The purpose of this study was to explore a substantial phenomenon related to flow experiences (immersion) in text-based interaction systems. Most previous research emphasizes the effects of challenge/skill, focused attention, telepresence, web characteristics, and systems' interface design on users' flow experiences in online environments. However, text-based interaction systems without telepresence features and web characteristics still seem to create opportunities for flow experience. To explore this phenomenon, this study incorporates subject involvement and interpersonal interaction as critical antecedents into the model of flow experience, as well as considers the existence of telepresence. Results reveal that subject involvement, interpersonal interaction, and interactivity speed are critical to focused attention, which enhances users' immersion. With regard to the effect of telepresence, the perceived attractiveness of the interface is a significant facilitator determining users' immersion in web-based, rather than in text-based, interaction environments. Interactivity speed is unrelated to immersion in both web-based and text-based interaction environments. The influence of interpersonal involvement is diminished in web-based interaction environments. The implications and limitations of this study are discussed.     

Cathodal transcranial direct current stimulation of the right Wernicke's area improves comprehension in subacute stroke patients

Previous studies have shown the appearance of right-sided language-related brain activity in right-handed patients after a stroke. Non-invasive brain stimulation such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) have been shown to modulate excitability in the brain. Moreover, rTMS and tDCS have been found to improve naming in non-fluent post-stroke aphasic patients. Here, we investigated the effect of tDCS on the comprehension of aphasic patients with subacute stroke. We hypothesized that tDCS applied to the left superior temporal gyrus (Wernicke’s area) or the right Wernicke’s area might be associated with recovery of comprehension ability in aphasic patients with subacute stroke. Participants included right-handed subacute stroke patients with global aphasia due to ischemic infarct of the left M1 or M2 middle cerebral artery. Patients were randomly divided into three groups: patients who received anodal tDCS applied to the left superior temporal gyrus, patients who received cathodal tDCS applied to the right superior temporal gyrus, and patients who received sham tDCS. All patients received conventional speech and language therapy during each period of tDCS application. The Korean-Western Aphasia Battery (K-WAB) was used to assess all patients before and after tDCS sessions. After intervention, all patients had significant improvements in aphasia quotients, spontaneous speech, and auditory verbal comprehension. However, auditory verbal comprehension improved significantly more in patients treated with a cathode, as compared to patients in the other groups. These results are consistent with the role of Wernicke’s area in language comprehension and the therapeutic effect that cathodal tDCS has on aphasia patients with subacute stroke, suggesting that tDCS may be an adjuvant treatment approach for aphasia rehabilitation therapy in patients in an early stage of stroke.     

Basketball training increases striatum volume

The striatum is associated with the learning and retention of motor skills. Several studies have shown that motor learning induces neuronal changes in the striatum. We investigated whether macroscopic change in striatum volume occurs in a segment of the human population who learned basketball-related motor skills and practiced them throughout their entire athletic life. Three-dimensional magnetic resonance imaging volumetry was performed in basketball players and healthy controls, and striatum volumes were compared based on basketball proficiency, region and side. We identified morphological enlargement in the striatum of basketball players in comparison with controls. Our results suggest that continued practice and repetitive performance of basketball-related motor skills may induce plastic structural changes in the human striatum.     

Is Human Life Absurd?

Philosophia - This essay examines whether or not absurdity is intrinsic to human life. It takes Camus’ interpretation of ‘The Absurd’ as its conceptual starting point. It traces...     

An outcome evaluation of Functional Family Therapy for court‐involved youth

This article presents results of a study on the effectiveness of Functional Family Therapy (FFT), a family intervention designed to prevent delinquency. The sample includes 155 court‐involved youth. This study employs two complementary outcomes: court‐obtained data on recidivism and the clinical data on clients’ psychosocial functioning, the Strengths and Needs Assessment (SNA). Adolescents in the treatment and in the comparison groups experienced statistically significant improvements on the majority of the SNA domains. Although youths in the treatment group improved more, the differences between the groups were not statistically significant. Multivariate analysis showed that youths in FFT had significantly lower odds of recidivism as measured by reconvictions for drug offenses, property offenses and technical violations. The results suggest that FFT was effective in reducing recidivism, however, such reductions cannot be attributed to improvements in the SNA scores.