A Plexiglas helmet and catheter protection assembly for chronic intravenous administration of drugs in small primates

A restraint and catheter-protection system consisting of a Plexiglas helmet and a nylon-tubing protector line has been developed to permit the long-term study of drug self-administration in monkeys. Frequent observations of monkeys in the system over a period exceeding a year have shown that the technique satisfies the requirements for long-term study of drug administration through an indwelling catheter and avoids several recurring problems inherent in other protection systems. Additional applications of the helmet and protector line are discussed.     

Book reviews

Encyclopaedia of Linguistics, Information and Control. Edited by A. R. Meetham with the assistance of R. A. Hudson. Oxford: Pergamon Press. 1969. Pp. xiv + 718. 300s.

The Biological Basis of Personality. By H. J. Eysenck. Springfield: Thomas. 1968. Pp. xv + 399. $18.50.

Scientific Basis of Dvug Dependence. Biological Council Symposium. Edited by H. Steinberg. London: Churchill. 1969. Pp. 429. 100s.

Minnesota Symposia on Child Psychology, Vol. 2. Edited by John P. Hill. Minneapolis: University of Minnesota Press. 1969. Pp. viii + 172.

Memory and Attention: an introduction to human information processes. By Donald A. Norman. Chichester, Sussex: John Wiley. 1969. Pp. ix + 201. 84s. (cloth); 44s. (paper). Verbal Learning and Memory: selected readings. By Leo Postman and Geoffrey Keppel. Harmondsworth: Penguin Books. 1969. Pp. 501. 12s.

Handbuch der Kinderheilkunde. Edited by H. Opitz and F. Schmidt. Rand VIII/I: Neurologie-Psychologic-Psychiatrie. Redigiert von F. Schmidt und H. Asperger. Berlin: Springer Verlag. Pp. 1060. Price DM385, S96.25.

Digital Computing. By R. S. Lehman and D. E. Bailey. London: John Wiley & Sons Ltd. 1969. Pp. xxiv + 303. 79s.

Real-Time Computers. By W. R. Uttal. New York: Harper & Row. 1968. Pp. xiv + 338. 93s.     

Control of-treadmill exercise of rats with hypothalamic stimulation

Running and resting behavior of rats was measured during treadmill exercise under conditions involving (1) rear-shock avoidance, (2) continuous electrical stimulation of the hypothalamus, or (3) no rear-shock and no hypothalamic stimulation. Hypothalamic stimulation was superior for eliciting consistent running with a minimum of resting. A second experiment demonstrated that decreases in hypothalamically elicited treadmill running resulting from prolonged exercise could be counteracted by increasing the intensity of the hypothalamic stimulus. A third experiment suggested that very little training was needed to induce a high and consistent level of running performance using hypothalamic stimulation.