Reinforcing effects of caffeine in coffee and capsules.

In a residential research ward the reinforcing and subjective effects of caffeine were studied under double-blind conditions in volunteer subjects with histories of heavy coffee drinking. In Experiment 1, 6 subjects had 13 opportunities each day to self-administer either a caffeine (100 mg) or a placebo capsule for periods of 14 to 61 days. All subjects developed a clear preference for caffeine, with intake of caffeine becoming relatively stable after preference had been attained. Preference for caffeine was demonstrated whether or not preference testing was preceded by a period of 10 to 37 days of caffeine abstinence, suggesting that a recent history of heavy caffeine intake (tolerance/dependence) was not a necessary condition for caffeine to function as a reinforcer. In Experiment 2, 6 subjects had 10 opportunities each day to self-administer a cup of coffee or (on different days) a capsule, dependent upon completing a work requirement that progressively increased and then decreased over days. Each day, one of four conditions was studied: caffeinated coffee (100 mg/cup), decaffeinated coffee, caffeine capsules (100 mg/capsule), or placebo capsules. Caffeinated coffee maintained the most self-administration, significantly higher than decaffeinated coffee and placebo capsules but not different from caffeine capsules. Both decaffeinated coffee and caffeine capsules were significantly higher than placebo capsules but not different from each other. In both experiments, subject ratings of "linking" of coffee or capsules covaried with the self-administration measures. These experiments provide the clearest demonstrations to date of the reinforcing effects of caffeine in capsules and in coffee.     

Smoking following myocardial infarction: a critical review of the literature

This paper critically reviews the available research on the effects of smoking cessation following acute myocardial infarction (MI). Studies that have examined the rate of smoking cessation following an MI indicate that approximately 1/3 to 1/2 of the smokers who suffer from MI subsequently reduce or quit smoking. Furthermore, studies that have examined subsequent mortality and morbidity suggest that individuals who quit smoking following MI exhibit lower mortality and morbidity than those who continue to smoke. It is argued that past studies may have overestimated post-MI smoking cessation rates, and by failing to control for a priori differences between quitters and continuing smokers (e.g., MI severity) may have underestimated the negative effects of smoking following MI. Suggestions for future research are proposed.     

A behavioural-pharmacological treatment of dually addicted patients

maintenance appears to be an effective means of treating narcotic addiction both because it blocks the effects of heroin and because patients are willing to accept methadone treatment. However, alcoholism has been found commonly to complicate methadone maintenance and to result in treatment failure. The regular ingestion of disulfiram, a drug which blocks ethanol metabolism, could provide a solution to this problem, but alcoholics tend not to persist in taking this drug, because unlike methadone it possesses no reinforcing properties. This paper describes a novel technique whereby the reinforcing action of methadone has been employed to maintain disulfiram-taking, and thus to arrest alcohol abuse and consequent treatment failure.     

君子不忧不惧：君子人格与心理健康——自我控制与真实性的链式中介

基于儒学经典命题提出君子人格通过自我控制与真实性的链式中介对心理健康产生正向效应的假设, 运用多种方法进行验证(总样本量为1169)。结果表明, 君子人格正向预测同时测量的心理健康(研究1)和6个月后测量的自尊、核心自我评价、情感平衡, 负向预测心理症状(研究4); 君子人格正向预测自我控制特质(研究1)和自我控制决策(研究3和研究4), 受到情境模拟操纵的自我控制提升心理健康与真实性(研究2), 受到回忆启动操纵的真实性提升心理健康(研究3); 链式中介作用也得到了同时和跨时间点测量、统计控制和实验控制等多方法结果的支持。君子人格水平较高的人, 更易自我控制, 由此感到自己的行为与真实自我更加一致与贯通, 因此具有更积极的心理状态。     

论医学的人本体及其文化内核

人和"人的世界"是系统的存在与演化过程,人和"人的世界"是文化的世界和流变。人,是人和"人的世界"的本体,文化是人和"人的世界"的内核及其展开。医学世界也是系统的存在与演化过程,是医学文化的展开与流变。医学人是医学世界的本体,医学文化内核及其展开形成医学世界,医学世界是医学文化流变的世界。     

多通道变化盲:理论、方法与进展

人们在特定条件下通常难以探测到事物的变化,这种现象发生在视、听、触感觉通道分别称为变化盲视、变话盲听和变化盲触。文章主要对以下四个方面进行详细的探讨:变化盲视及视觉表征理论、变化盲听及听觉信息加工机制、变化盲触及体表空间表征、多通道变化盲及空间注意和空间表征跨通道一致性本质。此外,文章还对多通道变化盲的理论深度和拓展方向及相关应用研究进行了展望。     

腹膜间皮细胞EMT在腹膜纤维化中的研究进展及意义

腹膜透析是终末期肾衰患者肾脏替代治疗的重要手段,腹膜纤维化导致腹透效能下降及超滤衰竭,制约着腹膜透析的应用.腹膜间皮细胞上皮细胞间充质转化是腹膜纤维化的起始和可逆环节,因此预防和逆转EMT的发生发展可能是阻止和延缓腹膜纤维化、超滤衰竭的最佳策略,并将带来巨大的社会和经济效益.     

CONTINGENCY MANAGEMENT INTERVENTIONS: EFFECTS ON TREATMENT OUTCOME DURING METHADONE DETOXIFICATION

We examined the effectiveness of a contingency management program in preventing relapse to illicit opiate use and increasing treatment retention during outpatient methadone detoxification treatment. Twenty male opiate addicts were randomly assigned to an experimental or control group. Following a 3-week methadone stabilization period, men in both groups received identical gradual methadone dose reductions during Weeks 4 through 9 and were maintained on placebo during Weeks 10 through 13. Beginning in Week 4, control patients received $5.00 for providing a specimen twice weekly. Experimental patients received $10.00 and a take home methadone dose for each opiate-free urine specimen but forfeited the incentives and participated in more intensive clinic procedures when specimens were opiate positive. The contingency management procedure slowed the rate of relapse to illicit opiate use. Experimental patients provided significantly more opiate-free urines during the methadone dose reduction in Weeks 4 through 9 than control patients, although the difference between groups was no longer significant during placebo administration in Weeks 10 through 13. In addition, the contingency management program improved treatment retention and reduced symptom complaints during the detoxification. The usefulness and limitations of contingency management procedures for outpatient methadone detoxification are discussed.     

The effects of a cooperation contingency on behavior in a continuous three-person environment

Five groups of three subjects resided for 10 or 15 days within a continuously programmed environment. Subjects followed a programmatic arrangement of required and optional private and social activities that determined the individual and group baseline behaviors into which experimental operations were introduced and withdrawn. A cooperation condition was in effect when all three subjects were required to select simultaneous access to a group area before it became available for use. A noncooperation condition was in effect when access to a group area could be selected by individual subjects, without regard to the other subjects' selections. For all groups, the effects of these two conditions on individual and group behaviors were investigated in reversal designs where several successive days occurred under each condition. Groups 1, 4, and 5 had the noncooperation condition interposed between cooperation conditions. Groups 2 and 3 had the cooperation condition interposed between noncooperation conditions. Durations of triadic activities, per cent of time in triadic activities, intercom use, and intersubject program synchronization were greater during cooperation conditions than during noncooperation conditions. These data show that a cooperation contingency within the behavioral program affected both social behavior and the collateral individual behavior necessary to execute the cooperation response.