Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals

The working-memory functions of the prefrontal cortex (PFC) are improved by stimulation of postsynaptic, alpha2A-adrenoceptors, especially in aged animals with PFC cognitive deficits. Thus, the alpha2A-adrenoceptor agonist, guanfacine, greatly improves working-memory performance in monkeys and rats following systemic administration or intra-PFC infusion. Alpha2A-adrenoceptors are generally coupled to Gi, which can inhibit adenylyl cyclases and reduce the production of cAMP. However, no study has directly examined whether the working-memory enhancement observed with guanfacine or other alpha2A-adrenoceptor agonists results from cAMP inhibition. The current study confirmed this hypothesis in both rats and monkeys, showing that treatments that increase cAMP-mediated signaling block guanfacine's beneficial effects. In aged rats, guanfacine was infused directly into the prelimbic PFC and was challenged with co-infusions of the cAMP analog, Sp-cAMPS. In aging monkeys, systemically administered guanfacine was challenged with the phosphodiesterase 4 inhibitor, rolipram, using intramuscular doses known to have no effect on their own. In both studies, agents that mimicked the actions of cAMP (rats) or increased endogenous cAMP (monkeys) completely blocked the enhancing effects of guanfacine on working-memory performance. These results are consistent with alpha2A-adrenoceptor stimulation enhancing PFC working-memory function via inhibition of cAMP-mediated signaling.     

UK and Spanish stranger sexual offenders crime scene behaviours and previous convictions: A cross-cultural comparison

International comparisons of previous convictions (PC) and crime scene behaviours (CSB) of stranger sexual offences can inform offender profiling strategies; especially the degree to which pragmatic models cross validate across countries. The present study compared PC and CSB of 474 UK and 418 Spanish cases. CSB and PC were analysed using Chi-square. UK stranger sexual offenders displayed a higher proportion of all CSB analysed. UK offenders also had a significantly higher proportion of PC with the exception of violence offences. There were no significant differences in sexual pre-convictions. In both the UK and Spain the CSB ‘reference to the police’ was significantly association with the PC ‘Criminal damage’ no other similar significant associations were found. Explanations for these findings include differences between the countries in regards to: legislation, crime recording processes, data coding processes, with additional consideration of any cultural, environmental and contextual factors.     

On the relation between spontaneous trait inferences and intentional inferences: An inference monitoring hypothesis

More than twenty five years after the beginning of research on spontaneous trait inferences (Winter & Uleman, 1984) an intriguing paradox in the impression formation literature remains: if traits are spontaneously inferred, why aren't they used to organize behavioral information and thereby facilitate recall under memory instructions (Hamilton, Katz, & Leirer, 1980)? We hypothesized that organization by traits is more evident under impression formation goals because only in that case then are inferences sufficiently monitored to permit their use in organizing impressions. As a consequence, such monitored traits can then be used strategically as retrieval cues. Merging the main features of the Winter and Uleman and the Hamilton et al. experimental paradigms, Experiment 1 simultaneously replicated the main results of both studies. Using a new recognition paradigm, Experiments 2 and 3 further tested this inference monitoring hypothesis by showing that monitoring of trait inferences only occurs under particular processing goals, and is dependent on the availability of cognitive resources.     

Refining the theory of basic individual values

We propose a refined theory of basic individual values intended to provide greater heuristic and explanatory power than the original theory of 10 values (Schwartz, 1992). The refined theory more accurately expresses the central assumption of the original theory that research has largely ignored: Values form a circular motivational continuum. The theory defines and orders 19 values on the continuum based on their compatible and conflicting motivations, expression of self-protection versus growth, and personal versus social focus. We assess the theory with a new instrument in 15 samples from 10 countries (N = 6,059). Confirmatory factor and multidimensional scaling analyses support discrimination of the 19 values, confirming the refined theory. Multidimensional scaling analyses largely support the predicted motivational order of the values. Analyses of predictive validity demonstrate that the refined values theory provides greater and more precise insight into the value underpinnings of beliefs. Each value correlates uniquely with external variables.     

“Identify-to-reject”: A specific strategy to avoid false memories in the DRM paradigm

Previous research using the Deese–Roediger–McDermott (DRM) paradigm has shown that lists of associates in which the critical words were easily identified as the themes of the lists produce lower levels of false memories in adults. In an attempt to analyze whether this effect is due to the application of a specific memory-editing process (the identify-to-reject strategy), two experiments manipulated variables that are likely to disrupt this strategy either at encoding or at retrieval. In Experiment 1, lists were presented at a very fast presentation rate to reduce the possibility of identifying the missing critical word as the theme of the list, and in Experiment 2, participants were pressed to give yes/no recognition answers within a very short time. The results showed that both of these manipulations disrupted the identifiability effect, indicating that the identify-to-reject strategy and theme identifiability play a major role in the rejection of false memories in the DRM paradigm.     

Reactions to the Fairness of Promotion Methods: Procedural justice and job satisfaction

Fairness in promotions is a core issue for organizations as it is directly related to some of the most important organizational outcomes. However, the majority of the existing research about this question has been focused on entry‐level selection, and there is a gap in knowledge in the context of promotions. This paper focuses on how workers’ perceptions of promotion systems affect organizational justice and job satisfaction. In the present study, 213 employees and supervisors from 31 different private sector organizations complete a survey regarding procedural justice (PJ), job satisfaction, transparency, promotion systems, and some demographic variables. The results show that participants who perceived organizational promotion methods as transparent reported a high level of perceived PJ, and that the methods they see as fairer are those based on assessment of performance. In addition, transparency is considered as an important antecedent of PJ. Moreover, the interaction between organizational rank and gender moderates the relationship between transparency and promotion systems with PJ. Finally, organizational justice is strongly related with job satisfaction.     

Developing Faith-Based Health Promotion Programs that Target Cardiovascular Disease and Cancer Risk Factors

Journal of Religion and Health - The aim of this study was to evaluate the impact of a faith-based health promotion program on the ideal health behaviors shared between cardiovascular...     

Congestive Heart Failure and Quality of Life

Our study aimed to assess the quality of life (QoL) of patients with congestive heart failure (CHF) and to correlate the different aspects of QoL with relevant socio-demographic variables, CHF severity, somatic comorbidities, other clinical variables and depressive symptomatology. In a cross-sectional study design, a community sample of 103 adult patients with CHF (mean age 68 years, 73 % male) was recruited from an outpatient cardiology practice. CHF severity was assessed with physician ratings of the New York Heart Association (NYHA) functional class and measurement of brain natriuretic peptide (BNP) levels. The psychometric evaluation of quality of life was made using the Medical Outcomes Study Short Form-36 (SF-36) and the Kansas City Cardiomyopathy Questionnaire (KCCQ). The Beck Depression Inventory Second Edition (BDI-II) assessed depressive symptoms. Using multiple linear regression, predictors of poorer QoL included being a female, being older, living alone, NYHA functional class ≥ II, higher levels of BNP comorbidity (such as renal insufficiency and cerebrovascular disease), fluid retention, depressive symptomatology (assessed by BDI-II) and treatment with anti-dyslipidemics, diuretics and β-blockers. Among these correlates, psychological distress was the most strongly related to QoL. Also, functional status measured by NYHA demonstrated a high impact on QoL. Our findings suggest the need to address such factors in developing effective care to improve psychological and functional status in order to enhance QoL in these patients.     

Modeling the Neurological Control of Human Movements

Although computer models have been extensively used in recent years to understand the way physical systems operate and interact, the enormous power of mathematical modeling and computer simulations has been difficult to implement for the benefit of neuroscientists studying the human motor control system. Nevertheless, homeomorphic models are now being used to explain and predict the neural and biomechanical aspects of different human movements. This paper argues for the importance of regarding model simulations as a supplementary approach to traditional methods of experimental investigation by drawing examples from both the experimental and the modeling literature. The discussion focuses on studies of the triphasic control signal for fast, goal-directed movements and on aspects of sampled data control for slow, tracking movements. The aim of this viewpoint article is to promote a more widespread use of modeling and simulation in the field of motor control.