The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies

Adults with Down syndrome (DS) are at a very high risk of developing early onset Alzheimer’s disease (AD) due to trisomy of chromosome 21. AD is preceded by a prolonged prodromal “pre-clinical” phase presenting with clinical features that do not fulfil the diagnostic criteria for AD. It is important to clinically characterise this prodromal stage to help early detection of the disease as neuropathology of AD is almost universal by the fifth decade in DS. There is a lack of knowledge of the trajectory of decline associated with the onset of dementia in this population and early signs may be overlooked or misdiagnosed, negatively affecting the quality of life of those affected and the use of early pharmacological or psychosocial interventions. The objective of this systematic review is to evaluate the published literature on longitudinal data in order to identify the cognitive and behavioural changes occurring during the prodromal and early stages of AD in this population. Fifteen peer-reviewed articles met the inclusion criteria, including a total number of 831 participants, with the duration between baseline and follow up varying from 1 year to 47 years. Results suggest that, compared to the general population for which short-term (episodic) memory loss is the most common indicator associated with the onset of AD, in people with DS, executive dysfunction and Behavioural and Psychological Symptoms of Dementia (BPSD) are commonly observed during pre-clinical and early stages and may precede memory loss. The review highlights the importance of using a broad spectrum of assessments in the context of heterogeneity of symptoms. Theoretical and practical implications are discussed, as well as the need for further research.     

Interrelations of Imagery Use,Imagery Ability,and Performance in Young Athletes

The present study aimed to provide a better understanding of the relationship between imagery use, imagery ability, the interrelation between these two constructs, and athletic performance for young athletes. Participants were 80 gymnasts between 7 and 16 years of age. We assessed 5 different functions of imagery use and imagery ability regarding cognitive and motivational imagery. Cognitive specific imagery use, motivational general-mastery imagery use, and goal imagery ability significantly predicted performance at competition, independent of the athletes’ age. Consequently, it is useful to support young athletes’ imagery use and imagery ability systematically in order to improve their learning processes and sports performance.     

Do Parents’ Academic Gender Stereotypes Influence Whether They Intrude on their Children’s Homework?

In this study, we explored the possibility that when parents endorse particular academic gender stereotypes (e.g., boys are better at math, girls are better at English) they are more likely to engage in uninvited intrusions with homework, intrusions which then undermine children’s confidence in these domains. Participants included 38 fifth to eighth grade students (mean age = 12.16 years, 60% girls, 87% White) and their mothers and fathers. The findings indicated that even though boys received more parental intrusive support with homework, girls were more sensitive to these intrusions, specifically when they involved math. Parents’ intrusive support mediated the relationship between parents’ math-related gender stereotypes and girls’ math ability perceptions, which suggests that these behaviors communicate to girls their parents’ math stereotype beliefs.     

Behavioral specifications of reward-associated long-term memory enhancement in humans

Recent functional imaging studies link reward-related activation of the midbrain substantia nigra-ventral tegmental area (SN/VTA), the site of origin of ascending dopaminergic projections, with improved long-term episodic memory. Here, we investigated in two behavioral experiments how (1) the contingency between item properties and reward, (2) the magnitude of reward, (3) the uncertainty of outcomes, and (4) the contextual availability of reward affect long-term memory. We show that episodic memory is enhanced only when rewards are specifically predicted by the semantic identity of the stimuli and changes nonlinearly with increasing reward magnitude. These effects are specific to reward and do not occur in relation to outcome uncertainty alone. These behavioral specifications are relevant for the functional interpretation of how reward-related activation of the SN/VTA, and more generally dopaminergic neuromodulation, contribute to long-term memory.     

Ten- and twelve-month-olds' visual anticipation of orientation and size during grasping

The anticipation of two object dimensions during grasping was investigated in 10- and 12-month-olds. We presented objects varying in both orientation and size and analyzed infants’ anticipatory hand configurations. We found in Experiment 1 that nearly all of the 12-month-olds (94%), but less than half of the 10-month-olds (40%), anticipated both dimensions before touching the object. Experiment 2 ruled out the possibility that this behavior resulted from the infants’ inability to anticipate the size of the stimuli. Thus, integrating two object dimensions during reaching seems to be difficult for 10-month-olds. In addition, we found a sequential adjustment when two dimensions were considered: Infants first adjusted the orientation and then the size. The implications of our findings concerning the planning and execution of grasping movements are discussed.     

Tracking 10-year competitive winning performance of judo athletes across age groups

Little information is available concerning early specialization and competitive success in judo across the early training years. Thus, the present objective was to verify the stability of individual competitive performance of a state-level championship for judo athletes who had been previously successful. For this, 406 athletes from six age groups (9 to 20+ years old) of each sex were followed for 10 years. Using recorded data from the S?o Paulo State Judo Federation beginning in 1999, the scores and standings for these judo players were analyzed. The proportion of medal winners during this period was not constant, differing from the grand mean in all groups of both 204 males and 202 females. At the end of this period, only 7% of the male and 5% of the female athletes had maintained their competitive levels. Successful competitive performance in early judo competition was not associated with success later in adulthood.     

Thought as Revolt in The Old Man and the Wolves

This article explores how Julia Kristeva's construction of a fictional narrative space enables her to examine the conditions that can produce a culture of revolt. Focusing on one of her novels, The Old Man and the Wolves, the article brings together Hannah Arendt's political philosophy (which provides a framework for Kristeva's depiction of totalitarianism) with Duns Scotus's principle of individuation and Giorgio Agamben's notion of quodlibet (“whatever singularity”) to argue that the future of a culture of revolt is closely connected to the role of women. By aligning feminine thought to political revolt, I demonstrate that Kristeva's revalorization of feminine experiences in the novel constitutes the basis of an ethics that includes the recognition of “whatever” forms of life that have been historically neglected.     

Self-defeating personality and memories of parents' child-rearing behaviour

A group of 132 nonclinical volunteers was given the Self-defeating Personality Scale and a short version of the Egna Minnen Betr?ffande Uppfostran (EMBU) scale to explore correlations of scores for adults' self-defeating traits with memories of parents' child-rearing behaviours. For men, the recall of two rejecting parents and, for women, the memory of a nonsupportive father were significantly correlated with scores of self-defeating traits. The latter scores correlated positively with memories of both overinvolved mother and father for men, while no significant correlation was found among women.     

Gender,Sexual Agency,and Friends with Benefits Relationships

Recent trends suggest that friends with benefits (FWB) relationships are prevalent among emerging adults on college campuses. Notably, young women are just as likely to participate in these relationships as young men, a finding that differentiates FWBs from heterosexual hook ups, where women traditionally report less participation. As such, it has been suggested that friends with benefits relationships may provide young women an avenue to explore and achieve sexual agency. Yet, whether emerging adults actually perceive friends with benefits relationships as affording women sexual agency has not been explored explicitly. In this study, we focus on female sexual agency and examine whether college women and men perceive FWB relationships as a means of expressing women’s sexual agency. Based on focus group discussions with 71 women and 35 men at a large public university, this study explores the myriad ways that students make sense of FWB relationships. Focus group discussions focused on the themes of empowerment, control, and safety in FWB relationships; we examine these themes in order to provide a nuanced analysis of FWB relationships as an increasingly widespread sexual behavior among young people on college campuses.