前列腺素E1注射液治疗早期2型糖尿病肾病临床观察

比较不同剂量的前列腺素E1注射液在早期2型糖尿病肾病患者中的,l鑫床疗效。最终随机纳入9l例早期2型糖尿病’肾病患者,分别接受10μg／d（A组,n=47）与20μg／d（B组,n=44）的前列腺素E1治疗,2周后观察8小时尿微量白蛋白排泄率（UAER）、血尿素氮（BUN）和肌酐（Cr）的变化。结果显示,两组患者治疗后...     

文化多元主义与人类团结的当代论证

立足于当前"少数群体"伸张自身权利的实际,"多元文化范式"才是契合时代要求的新哲学观念。这一范式是对传统形而上学"统一性"观念的解构而不是否弃。多元文化范式不再从绝对主义的立场来探寻社会统一性的价值根基,从而实现了哲学观念的重大变革。     

Abnormal diurnal pattern of cortisol secretion in patients after aneurysmal subarachnoid hemorrhage

Substantial evidence suggests that impairment of the hypothalamus?pituitary system can occur following an aneurysmal subarachnoid hemorrhage (aSAH). Given that the diurnal cortisol rhythm is primarily controlled by the hypothalamus?pituitary system, this study examined whether changes in diurnal cortisol rhythm occurred after aSAH. Cortisol concentrations were measured in the saliva samples collected from patients after aSAH and other types of cerebral hemorrhage (non-aSAH) in the post-awakening period and at night (21:00?h), and the cortisol awakening response (CAR) and diurnal cortisol decline were determined. The area under the cortisol curve from immediately after to 45?min after awakening (CARauc) in the aSAH patient group was comparable to that in the non-aSAH or healthy control groups. However, an obvious cortisol peak was not found after the awakening period, and the morning/nighttime cortisol ratio in the aSAH patient group was significantly lower than that in other examined groups due to higher nighttime cortisol concentrations. In aSAH patients, the CARauc and nighttime cortisol concentrations were negatively correlated with the Fisher CT grade. These results indicate that the diurnal cortisol rhythm is not regulated normally after aSAH, and cortisol secretory activity decreases as the volume of subarachnoid bleeding increases. Our findings will be helpful to understand altered hypothalamus?pituitary?adrenal axis function after aSAH.     

When Is Difficult Planning Good Planning? The Effects of Scenario‐Based Planning on Optimistic Prediction Bias

As a general rule, individuals tend to be optimistic in predicting when they will complete an upcoming activity. Building upon the ease of generation theory, we examined how dividing the planning process into multiple steps would impact the magnitude of optimism in “real world” planning. In Experiment 1 we found a decrease in optimistic prediction bias when individuals described their plans by generating a relatively difficult five‐step, rather than a relatively easy two‐step, optimistic scenario. In Experiment 2 the bias diminished when individuals generated the easy, rather than difficult, pessimistic scenario. In Experiment 3 the bias decreased even among individuals who generated the easy, rather than difficult, optimistic scenario when they were led to negatively interpret the feeling of ease.     

History,Current Status,and Future Prospects of Counseling in South Korea

Although the counseling profession was introduced to South Korea in the 1950s by American delegates of education, counseling has been only lately recognized as a specialized field that requires distinctive knowledge and skills. In this article, the authors describe the history and the current status of counseling in South Korea and then discuss challenges and future prospects.     

为分析性辩护

自从蒯因在著名的《经验论的两个教条》等一系列文章中对分析性做出批评以后,分析传统内已经很少有哲学家再对分析性概念持肯定态度了;随之受到威胁的是意义以及逻辑必然性的概念。     

青少年负性情绪信息记忆偏向的情绪弹性和性别效应

为了探讨情绪弹性和性别变量对青少年再认记忆负性情绪信息的影响,该实验采用再认记忆测验范式,以49名青少年为被试,以负性情绪图片为实验材料,考察了不同情绪弹性和性别的青少年再认负性情绪图片时的错误率差异。结果发现,情绪弹性对再认记忆负性情绪图片的主效应显著,统计效力明显。性别对再认记忆负性情绪图片的主效应显著,统计效力明显。情绪弹性与性别在再认记忆上的交互作用不显著。这说明青少年负性情绪信息加工过程中产生的记忆偏向效应受情绪弹性和性别因素的影响。     

Social,Religious and Spiritual Capital and Physical/Emotional Functioning in a National Sample of African Americans

Spiritual and religious capital are forms of the broader construct of social capital. The present study, using probability‐based sampling methods, surveyed a national sample of African American adults to examine the relative contributions of spiritual and religious capital to their physical and emotional functioning. Analyses were conducted to determine if these constructs made a unique contribution above and beyond general social capital. African American men and women (N = 803) were interviewed by telephone. Hierarchical linear regressions revealed that, across the full sample, although social capital was a positive predictor of physical and emotional functioning (p < .05 and p < .001), neither religious nor spiritual capital made an additional contribution to these outcomes. However, the relationships among these variables differed for men and women. Among men, social capital predicted positive emotional functioning (p < .001) but not physical functioning; spiritual and religious capital made no additional contribution to either outcome variable. Among women, social capital predicted positive emotional functioning (p < .01) but not physical functioning. However, religious capital did make a significant additional contribution to the prediction of emotional functioning (ΔR², p < .01). Dividing the sample into different age groups did not produce any different findings from those found with the sample as a whole. Findings are discussed in terms of implications for church‐ and faith‐based health promotion interventions aimed at health disparities reduction. Copyright © 2011 John Wiley & Sons, Ltd.     

GSK-3β activity in the hippocampus is required for memory retrieval

Several molecules were recently found to be important for the memory retrieval process in the hippocampus; however, the mechanisms underlying the memory retrieval remain poorly understood. GSK-3β has been implicated in the control of synaptic plasticity and memory formation. Here, we investigated the relationship between hippocampal GSK-3β activity and memory retrieval using behavioral and Western blotting methods. We found that GSK-3β was activated in the hippocampus after a retention session in the passive avoidance task. An intrahippocampal injection of the GSK-3β inhibitor, SB 216763, before the retention session blocked memory retrieval (but not reconsolidation) without affecting locomotor activity. These results suggest that GSK-3β activation would be essential for memory retrieval in the hippocampus.