The Association Between Physical Functioning and Self-rated General Health in Later Life: The Implications of Social Comparison

Self-rated general health has been used widely in health surveys as a single-item measurement of health-rated quality of life. Heterogeneity in self-evaluation of health has been well documented, yet the causes of this heterogeneity are poorly understood. This study evaluated the moderating effects of age, aging, gender, race, education and income on the relationship between physical functioning and self-rated general health using social comparison theory as a guiding framework. A longitudinal mixed-effects regression model was used to analyze a cohort enrolled into the Health and Retirement Study in 1993 that was interviewed at baseline and during four subsequent waves. The results revealed that the association between physical functioning and self-rated general health is weaker among subgroups that tend to have lower health status; i.e., older individuals, non-Caucasians and less educated individuals. These findings suggest the usefulness of social comparison theory in explaining self-rated general health and provide the basis for future research.     

Orthographic neighborhood size effect in Chinese character naming: orthographic and phonological activations

The present study examined the effects of orthographic neighborhood (N) size on the cognitive processes underlying Chinese character reading. Previous research has shown increasing N size facilitates word naming and recognition performance in alphabetic languages. Experiment 1 revealed that a large N size was associated with a general inhibition of processes underlying character reading, in contrast to previous findings with alphabetic languages. This inhibitory effect was influenced by regularity and consistency. Experiment 2 sought to assess the effects of higher-frequency neighbors on character naming performance. The results revealed that higher-frequency neighbors with different pronunciation to the target interfered with the phonological retrieval of targets. We propose that this type of interference may have caused the N size effect observed in Experiment 1. The results of Experiment 3 revealed that a large N size facilitated target naming in the absence of higher-frequency neighbors. The current results shed light on the processes underlying character naming, and we propose possible cognitive mechanisms of the N size effect on Chinese character naming.     

Disentangling the adult attention-deficit hyperactivity disorder endophenotype: parametric measurement of attention

Attention deficit hyperactivity disorder (ADHD) persists frequently into adulthood. The decomposition of endophenotypes by means of experimental neuro-cognitive assessment has the potential to improve diagnostic assessment, evaluation of treatment response, and disentanglement of genetic and environmental influences. We assessed four parameters of attentional capacity and selectivity derived from simple psychophysical tasks (verbal report of briefly presented letter displays) and based on a "theory of visual attention." These parameters are mathematically independent, quantitative measures, and previous studies have shown that they are highly sensitive for subtle attention deficits. Potential reductions of attentional capacity, that is, of perceptual processing speed and working memory storage capacity, were assessed with a whole report paradigm. Furthermore, possible pathologies of attentional selectivity, that is, selection of task-relevant information and bias in the spatial distribution of attention, were measured with a partial report paradigm. A group of 30 unmedicated adult ADHD patients and a group of 30 demographically matched healthy controls were tested. ADHD patients showed significant reductions of working memory storage capacity of a moderate to large effect size. Perceptual processing speed, task-based, and spatial selection were unaffected. The results imply a working memory deficit as an important source of behavioral impairments. The theory of visual attention parameter working memory storage capacity might constitute a quantifiable and testable endophenotype of ADHD.     

干细胞技术与肝硬化:共性与个性的新实践

干细胞横向分化(transdifferentiation)的能力,在肝脏再生过程中发挥作用,随着对干细胞的深入研究,干细胞技术为终末期肝病的治疗提供了新思路.本文对干细胞加以分类并综述了各种干细胞研究进展,对干细胞在肝脏疾病细胞治疗上的应用及前景作了总结和展望.     

The Effect of Parental Responsiveness on Differences in Psychological Distress and Delinquency between Singleton and Non-Singleton Chinese Adolescents

We assessed the differences in psychological distress and delinquent participation between singleton and non-singleton Chinese adolescents and the extent to which parental responsiveness (mother’s vs. father’s) might account for such differences. Using survey reports of 1,924 7th and 8th graders from three middle schools in the outskirts of Fuzhou, China, we observed small but significant differences between singleton and non-singleton adolescents. Singletons reported lower levels of psychological distress and delinquent participation than non-singleton adolescents. Furthermore, singletons received higher levels of parental responsiveness, which was inversely related to psychological distress and delinquent participation, respectively. The difference in psychological distress between singletons and non-singletons was completely mediated by both maternal and paternal responsiveness. Paternal responsiveness alone fully mediated the difference in delinquent participation between singleton and non-singleton adolescents. We discussed these results in light of both theoretical literature and empirical implications.     

积极情景线索对内隐攻击性的影响

通过向被试呈现代表积极情景线索的材料(一段含有互助、和谐信息的公益短片),运用内隐联想测验(IAT)范式,从内隐社会认知的角度来研究积极情境线索对个体内隐攻击性的影响,并分析这种影响是否具有性别差异。结果表明:未观看积极情景线索材料的被试表现出显著的内隐攻击性,而观看积极情景线索材料的被试的内隐攻击性不显著;积极情景线索的主效应显著,且这一效应不存在性别差异。这说明,积极情景线索能有效抑制个体的内隐攻击性,并支持自我攻击信念IAT是测量个体内隐攻击性的有效工具。     

Has someone moved my plate? The immediate and persistent effects of object location changes on gaze allocation during natural scene viewing

In this study, we investigated the immediate and persisting effects of object location changes on gaze control during scene viewing. Participants repeatedly inspected a randomized set of naturalistic scenes for later questioning. On the seventh presentation, an object was shown at a new location, whereas the change was reversed for all subsequent presentations of the scene. We tested whether deviations from stored scene representations would modify eye movements to the changed regions and whether these effects would persist. We found that changed objects were looked at longer and more often, regardless of change reportability. These effects were most pronounced immediately after the change occurred and quickly leveled off once a scene remained unchanged. However, participants continued to perform short validation checks to changed scene regions, which implies a persistent modulation of eye movement control beyond the occurrence of object location changes.     

一种对动物学习记忆能力突变筛查的新途

本文详细描述了一种全自动化的行为检测方案。在自然饲养环境/检测环境(24/7)中, 我们测量了小鼠针对两个给食器中获得食物的比例与它们在相应给食器停留时长的比例进行匹配的精确性与准确性。该方案是对传统条件性习得 (trials-to-acquisition) 行为测验设备的改进, 可以检测动物时间间隔能力的精确性与准确性, 对定时目标选择的相关概率的效果, 以及记忆一天中从不同给食器中获得食物次数的精确性与准确性。该压缩系统避免了在整个实验过程中对小鼠的持握操作, 可忽略实验者/技术员的实验操作时间, 而且可以递送小鼠置入实验环境后, 7~9个实验日中全部3组实验流程产生的大量结果。其中, 第一个实验流程为单个24小时周期内完成的时间匹配能力的筛查, 它对动物的时间、空间估计能力的记忆机制进行精确检测。因此, 该系统允许在有限的实验空间、较短的实验周期内, 对大量的实验小鼠进行有可能存在的学习记忆能力缺陷进行大规模筛查。此外, 该系统运行所依赖的软件可以在公共开放平台获得。     

工作记忆对时间加工的影响

非时间信息加工与时间加工的关系是复杂的, 存在双向干扰或单向干扰, 结果的不一致与任务所需的注意资源及工作记忆都有关。工作记忆的中央执行系统在时间加工中起主要作用, 同时进行的非时间任务对中央执行功能的需求越多, 两种任务之间的干扰程度越大。语言环和视空间模板对时间加工的影响与非时间信息的类型有关。工作记忆作为一个整体以工作记忆容量为指标, 计时成绩也表现出与工作记忆容量有关的年龄、智力等方面的差异。时间加工和工作记忆在额叶、顶叶、基底神经节等皮质存在共同的神经机制。未来应该丰富工作记忆的研究内容, 结合时间加工的分段性探讨工作记忆影响时间加工的具体进程及神经机制, 并力求在应用方面取得一定的成果。