How to do a meta‐analysis

Meta‐analysis is a statistical tool for estimating the mean and variance of underlying population effects from a collection of empirical studies addressing ostensibly the same research question. Meta‐analysis has become an increasing popular and valuable tool in psychological research, and major review articles typically employ these methods. This article describes the process of conducting meta‐analysis: selecting articles, developing inclusion criteria, calculating effect sizes, conducting the actual analysis (including information on how to do the analysis on popular computer packages such as IBM SPSS and R) and estimating the effects of publication bias. Guidance is also given on how to write up a meta‐analysis.     

The Infectious Diseases Society of America Lyme guidelines: a cautionary tale about the development of clinical practice guidelines

Flawed clinical practice guidelines may compromise patient care. Commercial conflicts of interest on panels that write treatment guidelines are particularly problematic, because panelists may have conflicting agendas that influence guideline recommendations. Historically, there has been no legal remedy for conflicts of interest on guidelines panels. However, in May 2008, the Attorney General of Connecticut concluded a ground-breaking antitrust investigation into the development of Lyme disease treatment guidelines by one of the largest medical societies in the United States, the Infectious Diseases Society of America (IDSA). Although the investigation found significant flaws in the IDSA guidelines development process, the subsequent review of the guidelines mandated by the settlement was compromised by a lack of impartiality at various stages of the IDSA review process. This article will examine the interplay between the recent calls for guidelines reform, the ethical canons of medicine, and due process considerations under antitrust laws as they apply to the formulation of the IDSA Lyme disease treatment guidelines. The article will also discuss pitfalls in the implementation of the IDSA antitrust settlement that should be avoided in the future.     

‘The Inner Citadels of the Color Line’: Mapping the Micro‐Ecology of Racial Segregation in Everyday Life Spaces

The role of racial segregation in perpetuating racial prejudice and inequality has been widely investigated by social scientists. Most research has concentrated on the macro‐sociological organization of institutions of residence, education and employment. In this paper, we suggest that such work may be usefully complemented by research that investigates the so‐called ‘micro‐ecology of segregation’ in everyday life spaces – the dynamic, largely informal network of social practices through which individuals maintain racial isolation within settings where members of other race groups are physically co‐present. Developing this argument, we discuss some historical examples of research on the micro‐ecological dimension of race segregation in the United States. We also draw examples from an ongoing program of work on everyday practices of contact and segregation in post‐apartheid South Africa. The paper concludes by exploring some conceptual and methodological implications of treating racial segregation as a micro‐ecological practice.     

Evaluating the invariance of the factor structure of the EPQ-R-N among adolescents

We examined the factor structure of the Neuroticism scale of the Eysenck Personality Questionnaire (EPQ-R-N; S. B. G. Eysenck, Eysenck & Barrett, 1985) and its factor invariance across sex and racial/ethnic groups in a sample of 1,979 adolescents. Using confirmatory factor analyses, we compared a hierarchical model to previous models of the EPQ-R-N and to single-factor and 3-factor structures. The hierarchical factor structure in which a general factor coexists with 3 group factors (depression, social concerns, and worry) was superior to alternative models. The general factor accounted for more than 60% of the variance in EPQ-R-N total scores and was invariant across sex and ethnicity. The 3 group factors varied across ethnicity and sex. We discuss the implications of these findings for conceptualization and assessment of neuroticism using the EPQ-R-N.     

Dimensions of Relationship Quality

Four studies examined the dimensions of relationship quality. In Study 1, based on a principal components analysis, four dimensions underlying the prototype of relationship quality were identified: intimacy, agreement, independence, and sexuality. The four–factorial structure was replicated both with a German sample (Study 2) and a Canadian sample (Study 3). Study 4 tested the validity of scales based on the four–factorial structure of relationship quality with German and Canadian samples. Relationship satisfaction was predicted well by the four scales, with intimacy contributing most, and sexuality least, to overall relationship satisfaction. The four scales correlated as predicted with other constructs relevant to close relationships, such as commitment, trust, love, and the like. Consequences for the measurement of relationship quality are discussed.     

Actin polymerization in lateral amygdala is essential for fear memory formation

Actin polymerization is involved in key neuronal functions such as intracellular trafficking and morphogenesis. In this study, we examined the role of actin polymerization in lateral amygdala (LA) in fear conditioning memory formation. Microinfusion of cytochalasin D, an actin polymerization inhibitor, into rat LA immediately before fear conditioning training impaired the formation of long-term fear memory (LTM) but not short-term fear memory (STM). Microinfusion of cytochalasin D into rat LA immediately after fear conditioning impaired LTM. Cytochalasin D had no effect on fear conditioning memory retrieval when injected immediately before LTM test. These results show that actin cytoskeleton rearrangement is essential for fear memory consolidation.     

Effect of fatigue on double pole kinematics in sprint cross-country skiing

The aim of the present study was to examine the effect of fatigue (physiological, mechanical, and muscular parameters) induced by a sprint simulation on kinematic parameters (cycle, phases, and joints angles) of the double pole technique. Eight elite skiers were tested for knee extensor strength and upper body power both before and after a three-bout simulation of sprint racing. They were video analyzed during the final part of the test track of bouts 1 and 3 using a digital camera. Results showed that skiers were in a fatigue state (decrease of the knee extensors voluntary force (-10.4+/-10.4%) and upper body power output (-11.1+/-8.7%) at the end of the sprint. During bout 3, the final spurt and cycle velocities decreased significantly (-7.5+/-12.3%; -13.2+/-9.5%; both p<.05). Angular patterns were only slightly modified between bouts 1 and 3 with trunk, hip, and pole angles being significantly greater for the third bout. The decrease of hip and trunk flexion and the lower inclination of the pole during the poling phase suggested a reduced effectiveness of the force application which could lead to a decrease in the cycle velocity.