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51.
Cortical plasticity associated with stuttering therapy   总被引:1,自引:0,他引:1  
Neuroimaging studies have indicated that persistent developmental stuttering (PDS) may be associated both with an abnormality in white matter of left-hemispheric speech areas and a right-hemispheric hyperactivity. The latter may compensate for the deficient structural connectivity in the left hemisphere. To investigate the effects of stuttering therapy on brain activity nine male adults with PDS underwent functional magnetic resonance imaging (fMRI) before and within 12 weeks after fluency shaping therapy. Brain response differences during overt sentence reading before and after therapy were assessed by utilizing random effects analyses. After therapy, a more widespread activation was observed in frontal speech and language regions and temporal areas of both hemispheres, particularly and more pronounced on the left side. Interestingly, distinct posttreatment left-sided activation increases were located directly adjacent to a recently detected area of white matter anomaly [M. Sommer, M.A. Koch, W. Paulus, C. Weiller, C. Buchel (2002). Disconnection of speech-relevant brain areas in persistent developmental stuttering. The Lancet, 360, 380-383] suggesting that fluency shaping techniques reorganize neuronal communication between left-sided speech motor planning, motor execution, and temporal areas. Hence, a therapeutic mechanism can be assumed to remodel brain circuitry close to the source of the dysfunction instead of reinforcing compensation via homologous contralateral brain networks. EDUCATIONAL OBJECTIVES: The reader will learn about and be able to: (1) describe brain activation changes detected shortly after fluency-shaping therapy; (2) identify left-hemispheric regions where a (re)functionalization after fluency-shaping therapy seems to occur adjacent to a recently described abnormal white matter region in PDS subjects; and (3) discuss how an effective cerebral compensation mechanism for stuttering could work.  相似文献   
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The effect of life-change events on perceptual augmentation-reduction was studied in 72 subjects (40 men, 32 women). In three experiments the kinesthetic figural aftereffect was measured prior to and after either a physical fitness program, a course in yoga, or training in Transcendental Meditation. Each program lasted a minimum of 8 wk. Subjects completing fitness training, all of whom were initially classified as augmenters, became reducers by the end of their program. Subjects enrolled in yoga and meditation courses remained relatively stable in their perceptual tendencies.  相似文献   
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Subjects learned a list of unrelated words to a criterion of either two successive correct trials (standard criterion), or two successive correct trials plus five additional recall trials (extra criterion). The extra recall trials significantly increased the subjective organization of recall. In the extra criterion group, a posthypnotic amnesia suggestion and a nonhypnotic distraction task produced equivalent decrements both in the amount recalled and in the subjective organization of recall. In the standard criterion group, suggestion and distraction reduced the amount recalled, but not the subjective organization of recall. The implications of these findings for understanding the contradictory results of earlier studies of recall organization during amnesia are discussed. Implications for theories of hypnotic amnesia are also discussed.  相似文献   
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This study utilised textual analysis to characterise the representation of fatherhood in the eight issues of Destiny Man magazine published in 2014. Stories that pertained to fatherhood and that were related to aspects of contemporary family construction, work, and identity formation were included for detailed text analysis. Our findings suggest that fatherhood is defined by access to wealth, and is inextricably linked to features of modern-day neoliberal capitalism with its bias towards wealth accumulation and economic standards of identity. Additionally, matters such as race and origin seem to be the primary classification criteria when it comes to self-identification as a father figure. From these data, we conclude that the notion of fatherhood is fluid; it changes continuously depending on the social class position of the incumbent male.  相似文献   
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These last years in France, the term ‘nosocomial infection’ has been replaced by ‘health-care associated infection’, which has a much broader definition. In all cases, the plausibility of the association between infection and the care provided deserved to be rigorously analyzed. To qualify an infection as nosocomial, the expert witness must at the judge's request determine that infection actually occurred within the health facility and is linked to health care. French Public Health Code as well the most recent jurisprudence give currently a rather close definition of nosocomial infection. The principle of faultness liability in the field of nosocomial infection has been enshrined in the law of March 4th 2002, the most severe situations (death; permanent functional deficit > 25 percent) being compensated by ONIAM, the French national office of compensation for nosocomial infection.  相似文献   
59.
Biased extensive measurement: The general case   总被引:1,自引:0,他引:1  
We develop a theory of biased extensive measurement which allows us to prove the existence of a ratio-scale without transitivity of indifference and with a property of homothetic invariance weaker than independence. These representations, which cover the cases of interval orders and of semiorders, reveal a unique biasing function smaller or equal to 1 that distorts extensive measurement and explains departures from its standard axioms. We interpret this biasing function as characterizing the qualitative influence of the underlying measurement process and we show that it induces a proportional indifference threshold.  相似文献   
60.
The masked-priming lexical decision task has been the paradigm of choice for investigating how readers code for letter identity and position. Insight into the temporal integration of information between prime and target words has pointed out, among other things, that readers do not code for the absolute position of letters. This conception has spurred various accounts of the word recognition process, but the results at present do not favor one account in particular. Thus, employing a new strategy, the present study moves out of the arena of temporal- and into the arena of spatial information integration. We present two lexical decision experiments that tested how the processing of six-letter target words is influenced by simultaneously presented flanking stimuli (each stimulus was presented for 150 ms). We manipulated the orthographic relatedness between the targets and flankers, in terms of both letter identity (same/different letters based on the target’s outer/inner letters) and letter position (intact/reversed order of letters and of flankers, contiguous/noncontiguous flankers). Target processing was strongly facilitated by same-letter flankers, and this facilitatory effect was modulated by both letter/flanker order and contiguity. However, when the flankers consisted of the target’s inner-positioned letters alone, letter order no longer mattered. These findings suggest that readers may code for the relative position of letters using words’ edges as spatial points of reference. We conclude that the flanker paradigm provides a fruitful means to investigate letter-position coding in the fovea and parafovea.  相似文献   
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