A single exposure to severe stressors causes long-term desensitisation of the physiological response to the homotypic stressor

Although some laboratories have reported that a single session of stress is able to induce a long-lasting sensitisation of the hypothalamic-pituitary-adrenal (HPA) response to further exposures to stress, we have found that a single exposure to severe emotional (immobilisation, restraint or shock) or systemic (endotoxin) stressors reduces the responsiveness of the HPA to the same, but not to a novel (heterotypic), stressor, in which case a slight sensitisation was observed. Long-term desensitisation has been found to reduce not only secretion of peripheral HPA hormones (ACTH and corticosterone), but also to reduce responses of central components of the HPA axis (c-fos and CRF gene expression at the level of the paraventricular nucleus of the hypothalamus, PVN). In addition, desensitisation also applies to the impact of the stressor on food intake and, probably, to stress-induced hyperglycaemia. The development of long-term desensitisation of the HPA axis does not appear to be a universal consequence of exposure to severe stressors as it was not observed in response to insulin-induced hypoglycaemia. Whether or not the development of long-term effects of stress depend on the specific pathways activated by particular stressors remains to be tested. The observed desensitisation of the HPA axis in response to the homotypic stressor shows two special features which makes it difficult to be interpreted in terms of an habituation-like process: (a) the effect increased with time (days to weeks) elapsed between the first and second exposure to the stressor, suggesting a progressive maturational process; and (b) the stronger the stressor the greater the long-term desensitisation. Therefore, it is possible that desensitisation of the HPA axis is the sum of two different phenomena: long-term effects and habituation-like processes. The contribution of the former may be more relevant with severe stressors and longer inter-stress intervals, and that of the latter with mild stressors and repeated exposures. Long-term stress-induced changes may not take place at the level of the PVN itself, but in brain nuclei showing synaptic plasticity and putatively involved in the control of the HPA axis and other physiological responses. As for the precise areas involved, these remain to be characterized.     

Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex

Extinction of auditory fear conditioning is thought to form a new memory. We previously found that rats with vmPFC lesions could extinguish fear to the tone within a session, but showed no recall of extinction 24 h later. One interpretation is that the vmPFC is the sole storage site of extinction memory. However, it is also possible that lesioned rats were unable to retrieve extinction memory stored in other structures. To determine if a latent extinction memory could be retrieved with additional training, we repeated the experiment but added an additional 5 d of extinction reminder trials. Replicating our previous findings, vmPFC-lesioned rats extinguished normally on day 1, but showed no recall of extinction on day 2. Over the next 5 d, however, lesioned rats showed significant savings in their rate of re-extinction. Thus, the vmPFC is not the only site where extinction memory is stored. Nevertheless, lesioned rats receiving only two extinction trials per day required twice as many days to initiate extinction as controls. Although recall of extinction is possible without the vmPFC, it is significantly delayed. We suggest that the vmPFC accelerates extinction by permitting access to recently learned extinction trials, thereby maximizing behavioral flexibility.     

Are readers of our face readers of our minds? Dogs (<Emphasis Type="Italic">Canis familiaris</Emphasis>) show situation-dependent recognition of human’s attention

The ability of animals to use behavioral/facial cues in detection of human attention has been widely investigated. In this test series we studied the ability of dogs to recognize human attention in different experimental situations (ball-fetching game, fetching objects on command, begging from humans). The attentional state of the humans was varied along two variables: (1) facing versus not facing the dog; (2) visible versus non-visible eyes. In the first set of experiments (fetching) the owners were told to take up different body positions (facing or not facing the dog) and to either cover or not cover their eyes with a blindfold. In the second set of experiments (begging) dogs had to choose between two eating humans based on either the visibility of the eyes or direction of the face. Our results show that the efficiency of dogs to discriminate between attentive and inattentive humans depended on the context of the test, but they could rely on the orientation of the body, the orientation of the head and the visibility of the eyes. With the exception of the fetching-game situation, they brought the object to the front of the human (even if he/she turned his/her back towards the dog), and preferentially begged from the facing (or seeing) human. There were also indications that dogs were sensitive to the visibility of the eyes because they showed increased hesitative behavior when approaching a blindfolded owner, and they also preferred to beg from the person with visible eyes. We conclude that dogs are able to rely on the same set of human facial cues for detection of attention, which form the behavioral basis of understanding attention in humans. Showing the ability of recognizing human attention across different situations dogs proved to be more flexible than chimpanzees investigated in similar circumstances.     

Determinants of picture naming times in Icelandic

Numerous studies have found that word frequency has a significant effect on the time it takes to name an object or read a word. Recently, claims have been made that this frequency effect is perhaps more correctly interpreted as an age of acquisition effect. This paper reports an experiment in which naming times in Icelandic for 175 stimuli from the Snodgrass and Vanderwart picture set were determined. A multiple regression analysis of naming times against a number of independent factors showed that objective age of acquisition was the strongest predictor of naming time, with familiarity and name agreement also showing a significant effect. The effect of word frequency was, however, not significant. Possible reasons for this are discussed.     

Effect of the similarity between target and global and local levels in hierarchical stimuli processing

The hypothesis of global precedence was investigated by manipulating the similarity between target and relevant level, and between target and global and local levels of hierarchical stimuli, both in divided and selective attention conditions. The similarity was measured on the basis of the amount of shared contour between two visual forms. The stimuli were circles, right-facing semicircles, i.e., 1/2 of the circumference missing, and right-facing partial circles with a 1/4 of the circumference missing. The circle was used as a target and, consequently, the similarity between target and semicircle and between it and the partial circle was 50% and 75%, respectively. In the divided attention condition, the results showed a local advantage in the two similarity conditions between target and distractor level (50% and 75%) and a bidirectional and symmetrical interference at both levels of similarity. However, in the 'selective attention condition', a local reaction time advantage was only found when the similarity between target and irrelevant level was of 50%. When attention was directed towards the global level, local interference increased depending on the decrease in the degree of the local level similarity. When the attention was directed towards the local level, there was global interference but it was independent of the degree of the global level similarity. These results show the importance of the physical shape of the local elements used in experiments with hierarchical stimuli, since they may determine the relative speed of global processing, facilitating or impairing it.     

Asymptotic judgment of cause in a relative validity paradigm

We report three experiments in which we tested asymptotic and dynamic predictions of the Rescorla-Wagner (R-W) model and the asymptotic predictions of Cheng's probabilistic contrast model (PCM) concerning judgments of causality when there are two possible causal candidates. We used a paradigm in which the presence of a causal candidate that is highly correlated with an effect influences judgments of a second, moderately correlated or uncorrelated cause. In Experiment 1, which involved a moderate outcome density, judgments of a moderately positive cause were attenuated when it was paired with either a perfect positive or perfect negative cause. This attenuation was robust over a large set of trials but was greater when the strong predictor was positive. In Experiment 2, in which there was a low overall density of outcomes, judgments of a moderately correlated positive cause were elevated when this cause was paired with a perfect negative causal candidate. This elevation was also quite robust over a large set of trials. In Experiment 3, estimates of the strength of a causal candidate that was uncorrelated with the outcome were reduced when it was paired with a perfect cause. The predictions of three theoretical models of causal judgments are considered. Both the R-W model and Cheng's PCM accounted for some but not all aspects of the data. Pearce's model of stimulus generalization accounts for a greater proportion of the data.     

Preference for copying unambiguous demonstrations in dogs (Canis familiaris)

In an earlier study (P. Pongracz et al., 2001), it was shown that human demonstration significantly enhances the detouring ability of dogs (Canis familiaris) around a V-shaped fence. The authors investigated the effect of the direction of the demonstrated detour and the dogs' detouring experience. They found that dogs' trial-and-error experience influences strongly the direction of the dogs' detours later, even if the demonstrator showed detours along the opposite side of the fence. However, dogs' preferences based on their own experiences were changed when the dogs observed demonstrations only on 1 side of the fence. Dogs with no trial-and-error experience followed the direction of 1-sided demonstrations. The change from dogs' own directions to the demonstrated directions seems not to be due to simple facilitative effects of social experience; the similarity with the demonstrated action depends on complex interactions between individual experience and socially provided information.