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91.
Risk assessment is an essential component of genetic counseling and testing, and the accuracy of risk assessment is critical
for decision making by consultands. However, it has been shown that genetic risk calculations may have high error rates in
practice. Risk calculations for autosomal dominant disorders are frequently complicated by age-dependent penetrance and sensitivities
of less than 100% in genetic testing. We provide methods of risk calculation for prototypical pedigrees of a family at risk
for an autosomal dominant disorder with age-dependent penetrance. Our risk calculations include scenarios in which the sensitivity
of genetic testing is less than 100%, and in which the sensitivity of genetic testing varies for different family members
at risk. Our Bayesian methods permit autosomal dominant disease probabilities to be calculated accurately, taking into account
all relevant information. Our methods are particularly useful for hereditary cancer syndromes, in which genetic testing can
seldom achieve 100% sensitivity. Our methods can be applied to many different scenarios, including those where the sensitivity
of genetic testing varies for different family members at risk.
The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services,
nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. 相似文献
92.
The association between children's numerical magnitude processing and mental multi-digit subtraction
Children apply various strategies to mentally solve multi-digit subtraction problems and the efficient use of some of them may depend more or less on numerical magnitude processing. For example, the indirect addition strategy (solving 72–67 as “how much do I have to add up to 67 to get 72?”), which is particularly efficient when the two given numbers are close to each other, requires to determine the proximity of these two numbers, a process that may depend on numerical magnitude processing. In the present study, children completed a numerical magnitude comparison task and a number line estimation task, both in a symbolic and nonsymbolic format, to measure their numerical magnitude processing. We administered a multi-digit subtraction task, in which half of the items were specifically designed to elicit indirect addition. Partial correlational analyses, controlling for intellectual ability and motor speed, revealed significant associations between numerical magnitude processing and mental multi-digit subtraction. Additional analyses indicated that numerical magnitude processing was particularly important for those items for which the use of indirect addition is expected to be most efficient. Although this association was observed for both symbolic and nonsymbolic tasks, the strongest associations were found for the symbolic format, and they seemed to be more prominent on numerical magnitude comparison than on number line estimation. 相似文献
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This article sheds light on the debate regarding political trust and protest activity. The debate boils down to the question whether trust in politics is positively or negatively related to protest activity. We exploit a dataset encompassing data on about 9,000 demonstrators spread over seven European countries. These demonstrators' trust in their parliaments varies widely, ranging from trustworthy capable, to corrupt incapable. We examine the diverging sociodemographic profiles and motivational dynamics that turn distrusting and trusting citizens into demonstrators. We hypothesize and show that distrusting demonstrators turn their back to institutionalized politics; for them, demonstrating substitutes the party politics they distrust. For trusting demonstrators, demonstrating supplements party politics. Trusting and distrusting demonstrators also differ considerably in terms of motivation. Distrusting demonstrators are stronger motivated to demonstrate than trusting demonstrators. Moreover, while political cynicism amplifies the motivation of distrusting demonstrators, it suppresses the motivation of trusting demonstrators. We conclude that the question to be answered is not so much whether people who engage in protest activity trust or distrust their political elites, but rather who the trusting and distrusting protesters are and why they protest. 相似文献
99.
This article studies how Dutch military personnel respond to austerity-related discontent. Based on the online survey (N = 579) conducted among military personnel we investigate 4 response strategies to austerity measures applied in the Dutch armed forces: voice (collective protest), exit (leaving the organization), silence (deliberately deciding not to protest), and neglect (engaging in anti-organizational behavior). We focus on how personnel combine these strategies and apply cluster analysis to identify 6 typical response patterns that we label as protesters, escapers, quiescents, conformers, obstructionists and combaters. We investigate how personal characteristics and perception of unique military environment influence the response of military personnel. We conclude that clusters we described are not only distinct in their behavior—their personal characteristics and perceptions differ as well. 相似文献
100.
We examined the development of magnitude representations in children (Exp 1: kindergartners, first-, second- and sixth graders, Exp 2: kindergartners, first-, second- and third graders) using a numerical same-different task with symbolic (i.e. digits) and non-symbolic (i.e. arrays of dots) stimuli. We investigated whether judgments in a same-different task with digits are based upon the numerical value or upon the physical similarity of the digits. In addition, we investigated whether the numerical distance effect decreases with increasing age. Finally, we examined whether the performance in this task is related to general mathematics achievement. Our results reveal that a same-different task with digits is not an appropriate task to study magnitude representations, because already late kindergarteners base their responses on the physical similarity instead of the numerical value of the digits. When decisions cannot be made on the basis of physical similarity, a similar numerical distance effect is present over all age groups. This suggests that the magnitude representation is stable from late kindergarten onwards. The size of the numerical distance effect was not related to mathematical achievement. However, children with a poorer mathematics achievement score seemed to have more difficulties to link a symbol with its corresponding magnitude. 相似文献