Depressive symptoms in outpatients with heart failure: Importance of inflammatory biomarkers,disease severity and personality

Objective: Depressive symptoms are highly prevalent in heart failure (HF) patients, however the underlying etiology of depression in HF patients remains yet unclear. Hence, the goal is to examine the relative importance of inflammation, disease severity and personality as predictors of depression in HF patients. Design: Depressive symptoms (Hospital Anxiety and Depression Scale, depression subscale) were assessed at baseline and one-year follow-up in 268 HF patients (75.6% men; mean age?=?66.7?±?8.7). Markers of inflammation (TNFα, sTNFr1, sTNFr2, IL-6 and IL-10), disease severity (e.g. New York Heart Association (NYHA) classification) and personality (Type D personality, loneliness) were assessed at baseline. Results: At baseline, NYHA class, body mass index, educational level, Type D personality and loneliness were significantly associated with depression. Higher NYHA class (B?=?2.25; SE?=?.83), higher educational level (B?=?1.41; SE?=?.48), Type D personality (B?=?2.56; SE?=?.60) and loneliness (B?=?.19; SE?=?.05) were also independently associated with higher depression levels at one-year follow-up (all p-values?<?.005). Inflammation, brain natriuretic peptide and left ventricular ejection fraction were not related to depression over time. Conclusions: Personality factors, but not inflammation, were independent concomitants of depressive symptoms in patients with HF. Gaining more insight into the etiology of depression in HF patients is important in order to identify potential targets for novel interventions.     

The eACS: Attentional control in the presence of emotion

We present a questionnaire – The Emotional Attentional Control Scale (eACS) – An adaptation of the original Attentional Control Scale (ACS) that assesses the voluntary control of attention. A low score on the ACS has been associated with high levels of anxiety and depression. As the ACS items are affectively neutral, some people scoring high on the ACS may still show low levels of attentional control (AC) in more emotionally-demanding situations. We propose that the eACS, which focuses on the emotional modulation of AC, may explain additional variance in AC deficits associated with psychopathology.     

A Way to the Soul of the Mentally ill by Gertrude Schwing

Abstract

Despite the skepticism and indifference to group psychotherapy that existed in the 1950s and 1960s within the psychoanalytic community in general and among the staff and administration of the Menninger Clinic in Topeka, Kansas in particular, a few clinicians there forged ahead in pursuit of incorporating this modality as an accepted treatment. After gaining some acceptance first in the hospital, we experienced a slow rate of growth, except with our trainees who were generally enthusiastic about group work. Many of them were intrigued first by their exposure to the group dynamics seminars and later by the didactic courses and supervised group work that eventually came to be required by the accrediting body for residency programs of the American Psychiatric Association. Visiting senior consultants and teachers, mainly associated with the American Group Psychotherapy Association, as well as an esteemed clinician from the Tavistock Clinic, also lent credibility and legitimacy to our effort. When group treatment began to be adopted by units of the Menninger Hospital in the early 1970s, there was a significant sea change in the attitude of the organization and group psychotherapy became a well established modality.     

Psychoanalysis and the Education of the Child by Gerald H. J. Pearson

A conceptualization is presented which encourages a renewed exploration of the way in which psychiatric patients discuss their medications in the group therapy setting. It is suggested that process-oriented group therapiststend to harbor subtle prejudices which may inhibit examination of this material. If we listen to medication-related discourse more carefully, we find that patients disclose important information about hopes and fears about treatment, self-efficacy, attitudes about control and authority, and other sensitive or disowned parts of experience. The process of interactions about medicines often reveals interpersonal difficulties, particularly around intimacy. Suggestions for intervening more effectively with this type of material are presented. The importance of medication attributions in revealing curative fantasies is discussed.     

General theories of explanation: buyer beware

We argue that there is no general theory of explanation that spans the sciences, mathematics, and ethics, etc. More specifically, there is no good reason to believe that substantive and domain-invariant constraints on explanatory information exist. Using Nickel (Noûs 44(2):305–328, 2010) as an exemplar of the contrary, generalist position, we first show that Nickel’s arguments rest on several ambiguities, and then show that even when these ambiguities are charitably corrected, Nickel’s defense of general theories of explanation is inadequate along several different dimensions. Specifically, we argue that Nickel’s argument has three fatal flaws. First, he has not provided any compelling illustrations of domain-invariant constraints on explanation. Second, in order to fend off the most vehement skeptics of domain-invariant theories of explanation, Nickel must beg all of the important questions. Third, Nickel’s examples of explanations from different domains with common explanatory structure rely on incorrect formulations of the explanations under consideration, circular justifications, and/or a mischaracterization of the position Nickel intends to critique. Given that the best and most elaborate defense of the generalist position fails in so many ways, we conclude that the standard practice in philosophy (and in philosophy of science in particular), which is to develop theories of explanation that are tailored to specific domains, still is justified. For those who want to buy into a more ambitious project: beware of the costs!     

William stanley jevons and the extent of meaning in logic and economics

This paper shows that William Stanley Jevons was not precursor of logical positivism despite his attempt to build up a unified science. His mechanical reductionism was directed towards this project, and Jevons tried to found mathematics on logic through the development of a theory of number. We show that his attempts were unsuccessful, and that his errors remain visible within the totality of his mechanical system, including his economics. We argue that both his logic and his economics are comprehensible only when interpreted in terms of extent of meaning, and that Jevons’ system gives rise to difficulties when interpreted in terms of intent of meaning. We argue that Jevons’ methodological recommendations were intended to bridge the gap between extent and intent of meaning. Although Jevons did not succeed in establishing a unified science, his flawed methodology resulted in one of the first applications of statistics to the social sciences     

The role of general and number-specific order processing in adults’ arithmetic performance

Digit order processing is highly related to individual differences in arithmetic performance. To examine whether serial scanning or associative mechanisms underlie order processing, order tasks (i.e. deciding whether three digits were presented in an order or not) were administered in two experiments. In the first experiment, digits were presented in different directions namely ascending, descending and non-ordered. For each direction, close and far distance sequences were presented. Results revealed reversed distance effects for ordered sequences, but ascending sequences elicited faster performance and stronger reversed distance effects than descending sequences, suggesting that associative mechanisms underlie order processing. In the second experiment, it was examined to which extent the relation between order processing and arithmetic is number-specific by presenting order tasks with digits, letters and months. In all order tasks similar distance effects were observed and similar relations with arithmetic were found, suggesting that both general associative mechanisms and number-specific mechanisms contribute to arithmetic.     

The reliability of and the relation between non-symbolic numerical distance effects in comparison, same-different judgments and priming

The development of number processing is generally studied by examining the performance on basic number tasks (comparison task, same-different judgment, and priming task). Using these tasks, so-called numerical distance effects are obtained. All these effects are generally explained by assuming a magnitude representation related to a mental number line: magnitudes are represented from left to right with partially overlapping representations for nearby numbers. In this study, we compared the performance of adults on these different tasks using non-symbolic stimuli. First, we investigated whether the effects obtained in these behavioral tasks are reliable. Second, we examined the relation between the three different effects. The results showed that the observed effects in the case of the comparison task and the same-different task proved to be reliable. The numerical distance effect obtained in the priming task, however, was not reliable. In addition, a correlation was found between the distance effects in the comparison task and the same-different task. The priming distance effect did not correlate with the other two effects. These results suggest important differences between distance effects obtained under automatic and intentional task instructions regarding the use of them as indices of mathematical ability.