Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli

Putting feelings into words (affect labeling) has long been thought to help manage negative emotional experiences; however, the mechanisms by which affect labeling produces this benefit remain largely unknown. Recent neuroimaging studies suggest a possible neurocognitive pathway for this process, but methodological limitations of previous studies have prevented strong inferences from being drawn. A functional magnetic resonance imaging study of affect labeling was conducted to remedy these limitations. The results indicated that affect labeling, relative to other forms of encoding, diminished the response of the amygdala and other limbic regions to negative emotional images. Additionally, affect labeling produced increased activity in a single brain region, right ventrolateral prefrontal cortex (RVLPFC). Finally, RVLPFC and amygdala activity during affect labeling were inversely correlated, a relationship that was mediated by activity in medial prefrontal cortex (MPFC). These results suggest that affect labeling may diminish emotional reactivity along a pathway from RVLPFC to MPFC to the amygdala.     

Cognitive resource limitations during sentence comprehension in Parkinson's disease

We report a single-case study of peripherally acquired dyslexia that meets the clinical criteria of "alexia without agraphia." The patient, AA, has a large infarct involving the left posterior cerebral artery. The most striking feature is a severe impairment in recognizing single visually presented letters that precludes explicit or implicit access to reading, even in a letter-by-letter fashion. AA can, however, differentiate letters from similar nonsense characters and digits, and he is also able to identify alphanumeric signs when the visual channel is bypassed (through somesthesic or kinesthesic presentation). Spelling tasks are also well performed. Since there is a breakdown in mapping a visually presented letter to its abstract graphemic representation, we propose the term "visuographemic alexia" for this kind of reading disorder. The pattern of deficits is interpreted following theoretical models previously developed in cognitive neuropsychology. An alexia for arabic numerals with preserved comprehension lends additional support for the crucial processing of different notational systems (e.g., phonographic vs logographic). More general perceptive disorders do not seem to account for these patterns; they are material-specific. Finally, we attempt to specify functional correlations with the implied neural networks.     

Billing and Record-Keeping for Familial Cancer Risk Counseling: A National Survey

We surveyed 111 genetic counselors providing cancer risk counseling (CRC) in order to document their billing and record-keeping practices. Of the 75 respondents, billing was generally done under the supervising physician with a wide variation in charges. Follow-up telephone interviews with 28 counselors who charge patients revealed that billing was usually done using the CPT codes for consultations, and the ICD-9 diagnostic codes for cancer (if applicable), a medical complaint, or a family history of cancer code. Most counselors exclude some clinical information from the patient's medical record. In consultation notes, 81% of counselors document a discussion of genetic testing, but only 37% document the patient's actual testing decision, and only 19% document test results. In anticipation of increased referrals for CRC, data are needed on the components of a CRC visit, the amount of time required to provide CRC, patient outcomes measures, and charges and reimbursement. The feasibility and advisability of keeping results separate from the patient's medical record also needs to be addressed.     

Fitting a response model forn dichotomously scored items

A method of estimating the parameters of the normal ogive model for dichotomously scored item-responses by maximum likelihood is demonstrated. Although the procedure requires numerical integration in order to evaluate the likelihood equations, a computer implemented Newton-Raphson solution is shown to be straightforward in other respects. Empirical tests of the procedure show that the resulting estimates are very similar to those based on a conventional analysis of item difficulties and first factor loadings obtained from the matrix of tetrachoric correlation coefficients. Problems of testing the fit of the model, and of obtaining invariant parameters are discussed.Research reported in this paper was supported by NSF Grant 1025 to the University of Chicago.     

Discriminability and central intermittency in same-different judgements

Four sets of paired visual stimuli (OO, XX, XO, or OX) were judged by 48 subjects to be either “same” or “different.” Decision latencies of the same and different judgement were studied as a function of the inter-stimulus interval (ISI). In Experiments I and II, in which stimulus durations were 70 millisec., decision latencies showed marked increases when the ISI was reduced to 100 millisec., but in Experiments III and IV, in which the stimulus durations were only 40 millisec., comparable increases did not occur until the ISI was reduced to 50 millisec. These increases were more marked for “same” than for “different” judgements, although overall decision latencies were generally shorter for “same” judgements. The effects of varying ISIs and stimulus durations are interpreted in terms of masking; they fail to support an hypothesis of central intermittency.