Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism

Several evidences suggest that brain histamine is involved in memory consolidation but the actual contribution of the hippocampal histaminergic system to this process remains controversial. Here, we show that when infused into the CA1 region of the dorsal hippocampus immediately after training in an inhibitory avoidance task, but not later, histamine induced a dose-dependent promnesic effect without altering locomotor activity, exploratory behavior, anxiety state or retrieval of the avoidance response. The facilitatory effect of intra-CA1 histamine was mimicked by the histamine N-methyltransferase inhibitor SKF-91844 as well as by the H2 receptor agonist dimaprit and it was blocked completely by the H2 receptor antagonist ranitidine. Conversely, the promnesic action of histamine was unaffected by the H1 receptor antagonist pyrilamine, the H3 receptor antagonist, thioperamide, and the NMDAr polyamine-binding site antagonist ifenprodil. By themselves, ranitidine, pyrilamine, thioperamide, and ifenprodil did not affect IA memory consolidation. Our data indicate that, when given into CA1, histamine enhances memory consolidation through a mechanism that involves activation of H2 receptors; however, endogenous CA1 histamine does not seem to participate in the consolidation of IA memory at least at the post-training times analyzed.     

Phenomenological reports diagnose accuracy of eyewitness identification decisions

This study investigated whether measuring the phenomenology of eyewitness identification decisions aids evaluation of their accuracy. Witnesses (N = 502) viewed a simulated crime and attempted to identify two targets from lineups. A divided attention manipulation during encoding reduced the rate of remember (R) correct identifications, but not the rates of R foil identifications or know (K) judgments in the absence of recollection (i.e., K/[1 − R]). Both RK judgments and recollection ratings (a novel measure of graded recollection) distinguished correct from incorrect positive identifications. However, only recollection ratings improved accuracy evaluation after identification confidence was taken into account. These results provide evidence that RK judgments for identification decisions function in a similar way as for recognition decisions; are consistent with the notion of graded recollection; and indicate that measures of phenomenology can enhance the evaluation of identification accuracy.     

Personality and Cognitive Ability as Predictors of Typical and Maximum Managerial Performance

Despite long-established distinctions between typical and maximum performance variables on both the predictor and criterion side, little previous research has directly addressed the extent to which these distinctions translate into differential predictor-criterion relationships. Using a sample of candidates for managerial positions, we examined relations of predictors conceptually linked to typical (i.e., broad, narrow, and compound personality traits) and maximum (i.e., broad and narrow cognitive abilities) performance with corresponding criterion measures (N = 84–873). Supervisory ratings of managerial performance served as the typical performance criterion, whereas maximum performance was assessed via an assessment center. Confirmatory factor analyses supported the distinction between typical and maximum performance. Results also confirmed our hypothesis that cognitive abilities are more strongly correlated with maximum performance than with typical performance and largely supported the expectation of the opposite pattern with personality traits as predictors.     

Moral Foundations and Heterogeneity in Ideological Preferences

Scholars have documented numerous examples of how liberals and conservatives differ in considering public policy. Recent work in political psychology has sought to understand these differences by detailing the ways in which liberals and conservatives approach political and social issues. In their moral foundations theory, Haidt and Joseph contend the divisions between liberals and conservatives are rooted in different views of morality. They demonstrate that humans consistently rely on five moral foundations. Two of these foundations—harm and fairness—are often labeled the individualizing foundations, as they deal with the role of individuals within social groups; the remaining three foundations—authority, ingroup loyalty, and purity—are the binding foundations as they pertain to the formation and maintenance of group bonds. Graham, Haidt, and Nosek demonstrate that liberals tend to disproportionately value the individualizing foundations, whereas conservatives value all five foundations equally. We extend this line of inquiry by examining whether different types of liberals and conservatives value the moral foundations to varying degrees. Using survey data (n = 745), we rely on a mixed‐mode latent class analysis and identify six ideological classes that favor unique social and fiscal policy positions. While most of the respondents belonging to these classes self‐identify as conservative, they endorse the moral foundations in varying degrees. Since our findings demonstrate considerable heterogeneity with respect to ideology and moral preferences, we conclude by encouraging scholars to consider this heterogeneity in detailing the motivational and psychological foundations of ideological belief.     

Internistische Psychosomatik

Die psychische Komorbidität internistischer Patienten im Sinne einer ICD-Diagnose des Kapitels F beträgt mehr als 35%: Neurotische, besonders somatoforme, Schmerz-, affektive Störungen und Suchterkrankungen sind häufig. Die Liegedauer ist bei psychischer Komorbidität deutlich erhöht. Es benötigen 5% der internistischen Patienten ein psychosomatisches Konsil. Neue, komplexe Behandlungsstrategien, wie Transplantationen, Kardioverter-Defibrillatoren, Medikamentenpumpen, erfordern häufig spezifische psychosoziale Interventionen. Ältere Patienten haben Erkrankungen, die zunehmend chronifizieren und komplexer werden. Damit werden Lebensqualität und psychische Komorbidität zu zentralen Outcomevariablen der Volkskrankheiten. Das zweite große Aufgabenfeld internistischer Psychosomatik ist die Untersuchung und die Behandlung psychosomatischer Patienten im engeren Sinne (Essstörungen, Schmerz- und somatoforme Störungen), weil internistische Diagnostik und Therapie erforderlich oder die Motivation der Patienten primär somatisch ist. Organisationsmodelle reichen von Konsil-/Liaisondiensten bis zu integrierten psychosomatischen Abteilungen oder Fachabteilungen an Allgemeinkrankenhäusern. Aussichtsreiche Forschungsstrategien werden neben der Erforschung psychosomatischer Mechanismen in der Entwicklung pragmatischer Behandlungsprogramme, ihrer Überprüfung in klinischen Studien und der Versorgungsforschung gesehen. Darüber hinaus sollte eine Intensivierung nationaler und internationaler Forschungsnetze erfolgen, wenn immer möglich unter Beteiligung anderer Disziplinen, um auch im Bereich der Forschung konkurrenzfähig zu bleiben.