Psychosis and autism as diametrical disorders of the social brain

Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia, bipolar disorder, and major depression) represent two major suites of disorders of human cognition, affect, and behavior that involve altered development and function of the social brain. We describe evidence that a large set of phenotypic traits exhibit diametrically opposite phenotypes in autistic-spectrum versus psychotic-spectrum conditions, with a focus on schizophrenia. This suite of traits is inter-correlated, in that autism involves a general pattern of constrained overgrowth, whereas schizophrenia involves undergrowth. These disorders also exhibit diametric patterns for traits related to social brain development, including aspects of gaze, agency, social cognition, local versus global processing, language, and behavior. Social cognition is thus underdeveloped in autistic-spectrum conditions and hyper-developed on the psychotic spectrum.;>We propose and evaluate a novel hypothesis that may help to explain these diametric phenotypes: that the development of these two sets of conditions is mediated in part by alterations of genomic imprinting. Evidence regarding the genetic, physiological, neurological, and psychological underpinnings of psychotic-spectrum conditions supports the hypothesis that the etiologies of these conditions involve biases towards increased relative effects from imprinted genes with maternal expression, which engender a general pattern of undergrowth. By contrast, autistic-spectrum conditions appear to involve increased relative bias towards effects of paternally expressed genes, which mediate overgrowth. This hypothesis provides a simple yet comprehensive theory, grounded in evolutionary biology and genetics, for understanding the causes and phenotypes of autistic-spectrum and psychotic-spectrum conditions.     

Effects of neonatal handling on play behavior and fear towards a predator odor in juvenile rats (Rattus norvegicus)

The effects of brief daily separation, also known as "handling," during the first 2 weeks of life on play behavior and fearfulness toward a predatory odor were assessed in juvenile rats. Handled rats were more playful than nonhandled control rats, and while handling had no effect on the direct response of these rats toward a predatory odor, handled rats did not exhibit a conditioned suppression of play when tested later in the same context where they had been exposed to the predatory odor. Handled rats were still wary of the environment in that they continued to show a heightened level of risk assessment behavior. These data suggest that early postnatal experiences may play a significant role in determining how an animal deals with predatory threats later in life.     

THE VAGARIES OF VEGETARIANISM

The following was meant to be a ‘fun paper’, which the author's honesty and natural seriousness of mind prevented from coming off well. Its main theme is that it is not wrong to eat meat provided the animals eaten are painlessly killed or – usually in the case of human animals – already dead. In the course of his remarks the author touches on: the bearing of affluence on vegetarianism; animal rights; child eating; treating animals as ends and with due Kantian respect; the inadequacy of the word ‘duty’; aesthetics and morals; the distinction between private behaviour – say driving on the left hand side of the road – and public duty – say advocating or legislating for driving on the right hand side of the road; our duties to vegetables, snakes, flying ants and Martians; and the desirability of irrationality in matters of duty; stealing and eating as much meat as possible as a way of bringing the meat industry to its knees; the contribution that animals should make to animal welfare, viz. allowing themselves to be eaten. He ends by emphasising the likeness of non‐human animals to human animals. 1     

Measuring motivation multidimensionally: development of the Assessment of Individual Motives-Questionnaire (AIM-Q)

We report the development of the Assessment of Individual Motives-Questionnaire (AIM-Q), a new instrument based on an evolutionary psychology theory of human motivation. It provides multitrait-multimethod (MTMM) assessment of individual differences on 15 motive scales. A total heterogeneous sample of N = 1,251 participated in eight studies that evaluated the homogeneity, internal consistency, test-retest reliability, and MTMM convergent and discriminant validities of the AIM-Q's three methods. These studies generally support the overall strategy of assessing individual differences in multiple evolutionary-based motives with multiple methods. Additional validity studies are underway and, when validated further, the AIM-Q may offer a promising option for evolutionary psychologists and behavioral geneticists wanting to incorporate individual differences into their research but have had to use existing self-report measures of personality, which were not designed for such a purpose. It may also offer clinical and counseling psychologists an additional approach to personality measures for the prediction of behavior.     

Inhibitory sensory preconditioning detected with a sodium depletion procedure

In each of two experiments, two groups of rats were exposed to three flavoured solutions: A (citric acid), B (salt), and AX (a compound of citric acid and saccharin). Both experiments used a between-subjects design in which a paired group received presentations of A followed by B, alternating with presentations of AX (i.e., A → B/AX), and an unpaired group received alternating presentations of A, B, and AX (i.e., A/B/AX). This arrangement was expected to establish X as an inhibitor of B in group paired but not in group unpaired. In Experiment 1, after preexposure all subjects received a single presentation of an XB compound, then experienced sodium depletion, and were tested for their consumption of X, which was greater in group unpaired than in group paired. In Experiment 2, after preexposure, all subjects received four presentations of a new flavour, C, in compound with B and subsequently, under sodium depletion, were tested for consumption of XC. Intake of the XC compound was less in group paired than in group unpaired. These results suggest that, in group paired, X acquired an inhibitory relationship with B both retarding the acquisition of an excitatory association with B (retardation test, Experiment 1) and reducing the response to a new stimulus, C, strongly associated to B (summation test, Experiment 2). These results provide direct evidence of inhibition between two neutral stimuli and, therefore, of inhibitory sensory preconditioning.     

Beneath the surface of the therapeutic interaction: the psychoanalytic method in modern dress

This study represents a new generation of psychotherapy process research, using multiple perspectives on the data of the analytic situation, including impressions of the treating analyst, ratings of complete sessions by clinical judges, and objective linguistic measures. Computerized measures of language style developed in the framework of multiple code theory were applied to verbatim session recordings from a psychoanalytic case; the measures are illustrated in microanalyses of the process in two sessions. The results show agreement between the linguistic measures and clinical ratings based on a psychoanalytic perspective. The linguistic measures look beneath the surface of the therapeutic interaction by relying largely on lexical items of which clinicians are not likely to be explicitly aware, and enable a new perspective on the therapeutic discourse as seen in the graphic images of the microprocess. While the results of this study were limited to a single case, the automatized measures can be readily applied to large samples and in repeated single case designs. Two goals of process research, using measures such as those developed in this study, are discussed: to develop measures of mediating variables that can be used to identify specific treatment effects in comparative outcome studies; and, beyond this pragmatic aim, to assess development of capacities for self-exploration and self-regulation as psychoanalytic treatment goals.     

Effectiveness of a Multiple Family Group Intervention for Juvenile First Offenders in Reducing Parent Stress

Parenting practices are major influences on incidents of juvenile delinquency. Stress experienced by parents of children with behavioral problems is a leading contributor to parenting practices. We investigated the extent to which parental stress was reduced by participation in an established multiple group family intervention, the Family Solutions Program, developed to reduce recidivism among juvenile offenders. We also examined parent stress by gender, ethnicity, dropout rates, intervention benefits at 3-month follow-up, single- versus two-parent households, and across dimensions of family functioning and parent-adolescent communication. Parents reported greater levels of parent stress than non-clinical parents prior to intervention. Parental stress did diminish in response to intervention, but not until follow-up to intervention completion. No differences were found on initial parent stress level between completers and non-completers of the intervention or between parent stress and gender or ethnicity of the parent; however, single-parent household was associated with significantly higher levels of parent stress. Family functioning was significantly negatively correlated with parental stress. Finally, open communication between juvenile first offenders and their parents improved significantly in response to the intervention both at post-intervention and at follow-up.