An analysis of some sensitizing agents in the pathogenesis of stress-induced gastric erosive disease

Prior surgical implantation of a venous catheter sensitized rats to coldimmobilization stress. Three of six catheterized females succumbed during the stress. The remaining rats fell into two groups in terms of their core temperature at the end of the stress period: Male uncatheterized rats had higher temperatures than rats in the other three groups. No relation was found between catheter patency and magnitude of hypothermia. Degree of gastric disease paralleled the core temperature findings in that the male uncatheterized rats had significantly fewer gastric erosions than the rats in the other three groups. Additionally, a robust effect of gender was found with uncatheterized females showing more hypothermia and more gastric disease than uncatheterized males. A subsequent experiment was conducted to evaluate whether anesthesia or wearing the protective spring was responsible in part for the sensitization seen. Here, the gender difference was less although females consistently averaged lower core temperatures after stress than did males. Despite similar core temperatures after stress, females that were prepared with the protective spring apparatus developed more gastric disease than female controls or similarly treated males. Thus, the additional sensitization exhibited by females in the first experiment may relate to the fact that both catheterization and the taping procedure were sensitizers while only catheterization was a sensitizer for males.     

The effects of ethanol intoxication on phobic anxiety

Behavioral conceptions of alcohol abuse often include the hypothesis that drinking behavior is a negatively reinforced operant, with ethanol intoxication viewed as alleviating aversive environmental and internal states. This hypothesis has not been confirmed or refuted by previous studies which employed mild stressors and limited assessment methodology. In the present experiment, 22 patients with severe phobias approached their phobic animal under two consecutive conditions—first while sober and second after drinking either a placebo or an intoxicating dose of ethanol. The severe anxiety induced was assessed behaviorally, physiologically and by the patient's self-report of fear. The intoxicated patients did not experience decreased anxiety, tachycardia or avoidance, compared to the placebo group. These results have clinical implications and suggest the need to reconsider tension-reduction theories of alcohol abuse.     

The Most Important Election of Our Lifetime: Focalism and Political Participation

This article argues that a psychological bias called “focalism” contributes to an overestimation of the differences between political candidates, which in turn increases participation and polarization. Focalism causes people to confuse the allocation of attention to things with the importance of those things. Because attention to politics typically centers on conflict, the result is an exaggeration of differences across the partisan divide. I test this intuition using an experimental design that provides all respondents with all the information they need to estimate how much Joe Biden and Donald Trump objectively disagreed on policy positions just before the 2020 election. I find that shifting attention—toward either those positions the candidates agreed or disagreed with each other on—influences beliefs about the differences between candidates. The effect exceeds that of identifying as a Democrat or as a Republican. Beyond those perceptions, focalism increases turnout intentions, perceptions of election importance, negative feelings towards the out-candidate, and affective polarization.     

Replies to Wallace,Queloz, and Kirwin

In this article, I reply to the comments offered by R. Jay Wallace, Matthieu Queloz, and Claire Kirwin on my book, The Will to Nothingness. An Essay on Nietzsche's Genealogy of Morality (OUP, 2021). These comments and my replies cover central features of the book, including my analysis of ressentiment as an expression of the will to power; the concept of self-undermining functionality I introduce to make sense of Nietzsche's critique of the ascetic ideal; and my reasons for omitting to examine the “unconditional will to truth,” which he presents as the latest embodiment of this ideal.     

Direct quantitative judgments of sums and a two-stage model for psychophysical judgments

Judged magnitudes of differences between stimuli have previously been shown to support a two-stage interpretation of magnitude estimation, in which input transformations and output transformations are each describable as power functions. In an effort to provide support for the model independent of the difference estimation procedure. the present investigation employed two additional judgment tasks. We obtained magnitude judgments and category judgments of the combined magnitudes (sums) of paired weights from two groups of Ss. Values of the inferred input exponent k calculated from the two sets of data were very similar and were also remarkably similar to the exponent previously calculated from magnitude estimations of differences between weights. The output exponent calculated from magnitude judgments of sums described a concave upward function; however. the similar function describing category judgments was essentially linear. These results show that the inferred input exponent is not the result of the difference estimation task, and in addition provides support for the contention that the interval scale may be a less biased sensory measure than the magnitude scale. The introduction of an additive constant to the model improved its fit to the data but the rule by which it was introduced made very little difference.     

Bar holding during escape conditioning

To analyze bar-holding behavior during escape conditioning three rats were trained to escape from shock by pressing a bar, and three were trained to escape by releasing a bar. Bar holding behavior was stronger and more stable under the release condition. These effects were related to the relative shock duration of onbar versus offbar shocks.     

Built Space and the Interactional Framing of Experience During a Murder Interrogation

Human interaction and communication involve space in multiple ways. This paper examines the spatial and interactional order of a covertly video-taped police interrogation. When the participants enter the interrogation room and become engaged in the interrogation process, the room itself is a constraint and a resource for interaction. While interacting within a built environment, the participants appropriate their material surroundings in ways that constitute a spatial order and make possible certain arguments. This paper examines how the physical structure of the interrogation room is differentially appropriated, used, and filled in by the participants'; territorial and postural manoeuvers over the course of their interaction; and how the spatial structures thus created by the bodily appropriation of the physical locale are subsequently formulated by talk and thereby used as a metaphorical resource to frame the participants' situated experience. Through this embedded process, the interrogators move the suspect toward confession.