Relations of Neuroticism and Attentional Control with Symptoms of Anxiety and Aggression in Non-Clinical Children

The present study examined the associations between neuroticism and attentional control and the occurrence of symptoms of psychopathology in children. A large sample of non-clinical children aged 9 to 17 years (N = 409) completed questionnaires measuring neuroticism, attentional control, and symptoms of anxiety and aggression. Results demonstrated that neuroticism was positively associated with symptoms of anxiety and aggression, whereas attentional control was negatively linked to such symptoms. Regression analyses showed that both neuroticism and attentional control accounted for an independent and significant proportion of the variance in children’s anxiety and aggression symptoms. Further, tentative support was found for the notion that neuroticism and attentional control have an interactive effect on symptoms of anxiety and aggression. Results did not show that age had an influence on the emergence of this interaction.     

Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study

Hoarding behavior occurs frequently in obsessive-compulsive disorder (OCD). Results from previous studies suggest that individuals with OCD who have hoarding symptoms are clinically different than non-hoarders and may represent a distinct clinical group. In the present study, we compared 235 hoarding to 389 non-hoarding participants, all of whom had OCD, collected in the course of the OCD Collaborative Genetics Study. We found that, compared to non-hoarding individuals, hoarders were more likely to have symmetry obsessions and repeating, counting, and ordering compulsions; poorer insight; more severe illness; difficulty initiating or completing tasks; and indecision. Hoarders had a greater prevalence of social phobia and generalized anxiety disorder. Hoarders also had a greater prevalence of obsessive-compulsive and dependent personality disorders. Five personality traits were independently associated with hoarding: miserliness, preoccupation with details, difficulty making decisions, odd behavior or appearance, and magical thinking. Hoarding and indecision were more prevalent in the relatives of hoarding than of non-hoarding probands. Hoarding in relatives was associated with indecision in probands, independently of proband hoarding status. The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families.     

Gay male sexual assault survivors: the relations among internalized homophobia, experiential avoidance, and psychological symptom severity

This study explored the relations among internalized homophobia (IH), experiential avoidance, and psychological symptom severity in a community sample of 74 gay male sexual assault survivors. Results indicated that IH is associated with both depressive and posttraumatic stress disorder (PTSD) symptom severity. IH accounted for more variance than assault severity in predicting both PTSD and depression symptom severity. IH and experiential avoidance similarly predicted PTSD symptom severity. In comparison with IH, however, experiential avoidance is a stronger predictor of depression symptom severity. Results also showed that experiential avoidance partially mediated the relation between IH and both depressive and PTSD symptom severity. The implications of these findings are discussed and suggestions for future research are provided.     

Fusion or Internalized Homophobia? A Pilot Study of Bowen's Differentiation of Self Hypothesis With Lesbian Couples

Bowen, using the concept of differentiation, hypothesized that the way individuals learn to deal with their relationships with families of origin will influence the way they manage their relationships with their partners. This study surveyed a group of 53 lesbian couples on differentiation of self, internalized homophobia, and relationship satisfaction. We found that lesbian couples were not significantly different in their level of differentiation than random pairs. We also found that there was a positive relationship between differentiation of self and relationship satisfaction and that when considered together, internalized homophobia had the more significant connection to relationship satisfaction than did differentiation of self Implications for therapy are drawn from these findings.     

Rapid forgetting of social transmission of food preferences in aged rats: relationship to hippocampal CREB activation

A major characteristic of age-related changes in memory in rodents is an increase in the rate of forgetting of new information, even when tests given soon after training reveal intact memory. Interference with CREB functions similarly results in rapid decay of memory. Using quantitative immunocytochemistry, the present experiment examined the number of CREB- and pCREB-immunoreactive neurons in three regions of the dorsal and ventral hippocampus (dentate gyrus, CA3, and CA1) as a function of age and training. Rats were trained in a social transmission of food preference task. Using different food pairings, memory was tested in each rat immediately and 1, 2, 3, and 7 d later. Both young and old rats had intact and comparable memory scores at the immediate and 24-h tests, but old rats exhibited more rapid forgetting thereafter relative to that of young rats. The main findings were that training resulted in large increases in the number of pCREB-immunoreactive cells throughout the hippocampus in both young and aged rats. However, particularly in the ventral hippocampus, the training-elicited increase in pCREB-positive neurons was significantly lower in old than in young rats. Based on Western blot analyses in a separate set of rats, CREB levels were not responsive to training but were lower in the ventral hippocampus of old rats than of young rats. The present findings suggest that lower activation of CREB after training may contribute to the rapid forgetting seen in aged rats.     

Self-Assembly, Self-Organization: Nanotechnology and Vitalism

Over the past decades, self-assembly has attracted a lot of research attention and transformed the relations between chemistry, materials science and biology. The paper explores the impact of the current interest in self-assembly techniques on the traditional debate over the nature of life. The first section describes three different research programs of self-assembly in nanotechnology in order to characterize their metaphysical implications: (1) Hybridization (using the building blocks of living systems for making devices and machines) ; (2) Biomimetics (making artifacts mimicking nature); (3) Integration (a composite of the two previous strategies). The second section focused on the elusive boundary between self-assembly and self-organization tries to map out the various positions adopted by the promoters of self-assembly on the issue of vitalism.

Glucose attenuation of paradoxical sleep deficits in old rats.

Glucose administration enhances memory in several amnestic populations, including old humans and rodents. The present experiment demonstrates that glucose also enhances measures of sleep in old rats. Three-hour day-time sleep EEGs were assessed in 3- and 24-month-old rats. The animals received injections of saline or glucose (100, 500, and 1000 mg/kg) on different days in a counter-balanced order. At doses of 100 and 500 mg/kg, glucose augmented the duration of paradoxical sleep bouts and total paradoxical sleep time in old, but not young, rats. Within 2 weeks after the sleep tests, measures of several brain neurotransmitter functions were obtained. Glucose was more effective in enhancing paradoxical sleep in those individual aged rats with high levels of hippocampal choline acetyltransferase and occipital cortex serotonin concentrations than in aged rats with lower levels on these neurochemical measures. The findings suggest that glucose attenuates selective age-related sleep deficits in old rats. More generally, these results add to a growing body of evidence indicating that moderate doses of peripheral glucose can influence a variety of CNS measures.     

An analysis of item gains and losses in retroactive interference.

The repeated-testing paradigm is used to study both retroactive interference and hypermnesia (the improvement in memory across repeated tests). Considerable theoretical progress has been made by separately analyzing the 2 components of hypermnesia: the recovery of previously unrecalled items on later tests (item gains) and the forgetting of previously recalled items on later tests (item losses). Item gains increase with increases in item-specific processing, whereas item losses decrease with increases in relational processing. The authors suggest that separate analysis of item gains and losses in retroactive interference research may also prove fruitful. Three experiments showed that an interpolated list affects item gains but not losses, whereas processing similarity between the target and interpolated lists affects losses but not gains. These results are interpreted within the relational-item-specific processing framework.