An evaluation of recollection and familiarity in Alzheimer’s disease and mild cognitive impairment using receiver operating characteristics

There is a need to investigate exactly how memory breaks down in the course of Alzheimer’s disease (AD). Examining what aspects of memorial processing remain relatively intact early in the disease process will allow us to develop behavioral interventions and possible drug therapies focused on these intact processes. Several recent studies have worked to understand the processes of recollection and familiarity in patients with mild cognitive impairment (MCI) and very mild AD. Although there is general agreement that these patient groups are relatively unable to use recollection to support veridical recognition decisions, there has been some question as to how well these patients can use familiarity. The current study used receiver operating characteristic (ROC) curves and a depth of processing manipulation to understand the effect of MCI and AD on the estimates of recollection and familiarity. Results showed that patients with MCI and AD were impaired in both recollection and familiarity, regardless of the depth of encoding. These results are discussed in relation to disease pathology and in the context of recent conflicting evidence as to whether familiarity remains intact in patients with MCI. The authors highlight differences in stimuli type and task difficulty as possibly modulating the ability of these patients to successfully use familiarity in support of memorial decisions.     

PSYCHOLOGICAL OUTCOMES AMONG LESBIAN SEXUAL ASSAULT SURVIVORS: AN EXAMINATION OF THE ROLES OF INTERNALIZED HOMOPHOBIA AND EXPERIENTIAL AVOIDANCE

This study explored the relations among internalized homophobia (IH), experiential avoidance, and psychological symptom severity in a community sample of 72 lesbian sexual assault survivors. Results indicated that IH is associated with both experiential avoidance and posttraumatic stress disorder (PTSD) symptom severity. In addition, experiential avoidance is related to both PTSD and depression symptom severity. Finally, experiential avoidance completely mediated the relation between IH and PTSD symptom severity. The implications of these findings are discussed and suggestions for future research are provided.     

The influence of emotional awareness and expressiveness on care-giving burden and health complaints in women and men

This study was designed to investigate the role of emotional awareness and expressiveness as influences on the experience of burden and impaired health for women and men maintaining a spouse or relative at home who had been diagnosed as having dementia. One hundred and thirty-one Caucasian care givers, 41 males and 90 females, participated in the study. Multivariate analysis of variance indicated that women scored higher than men on measures of burden, health complaints, and awareness of others' emotions. Regression analysis indicated that self-awareness of emotions interacted with care-giver gender to decrease health complaints for female care givers but increased health complaints for male care givers. Self-awareness of emotions also increased feelings of burden for male care givers in general and for female care givers experiencing low levels of burden. Awareness of others' emotions tended to reduce feelings of burden. Emotional expressiveness did not influence burden or health complaint scores.This research was funded by grants from the Health Research Funds of Quebec, the Quebec Council for Social Research, and the Montreal Alzheimer Society. The authors would like to express their gratitude to Valerie Takeda, Charlene Stamegna, and Helene Fyfe for their work on the project, and to the families, patients, and staff of the various referral agencies for their cooperation with the study.To whom reprint requests should be addressed at Centre for Research in Human Development, Concordia University, 1455 de Maisonneuve Boulevard West, Montreal, Quebec, Canada, H3G 1M8.     

The Therapeutic Frame: On the Need for Flexibility

A fundamental function of the therapeutic frame is protection of the therapeutic process from the intrusion of elements antithetical to the best interest of the client and detrimental to treatment outcome. It is argued that dogmatic interpretation of the frame promotes conformity rather than growth in the client, blinds the therapist to legitimate issues of client diversity, and constricts the therapist's ability to be appropriately responsive to the client. It is suggested that while the frame is essential to maintain the focus of treatment on the welfare of the client, inflexible adherence undermines this purpose.     

The role of psychosocial context, age, and intelligence in memory performance of older men.

The hypothesis that psychosocial contextual factors contribute to developmental changes in memory was examined using 326 male World War II veterans. Availability of young adult intelligence scores made it possible to separate the contributions of contextual variables and age to maintenance of general intelligence from their direct contributions to performance on 4 memory tasks. Being younger, healthier, more educated, more introverted, more intellectually active, and more satisfied with social support predicted less intellectual decline and, indirectly, better memory performance. Age, personality, locus of control, and extent of social support directly contributed to performance on 1 or more memory tasks. Age contributions were consistent with Craik's (1986) proposed continuum of task demands for self-initiated effort. Possible elaborations of Craik's hypothesis to accommodate contextual variables are suggested.     

Scopolamine-induced deficits in spontaneous alternation performance: attenuation with lateral ventricle injections of glucose.

This experiment determined whether centrally administered glucose can attenuate scopolamine-induced deficits in spontaneous alternation performance. All rats were surgically prepared with indwelling cannulae directed at the lateral ventricle. Thirty min prior to alternation tests, rats received systemic (ip) injections of saline or scopolamine (3 mg/kg). Ten or thirty min prior to training, the rats also received a direct injection into the lateral ventricle of either artificial cerebrospinal fluid (CSF) or glucose (3 micrograms in 1 microliter). Scopolamine significantly impaired spontaneous alternation performance relative to controls. Additional treatment with ICV glucose 30 min, but not 10 min prior to testing, significantly attenuated the scopolamine-induced deficit. These results add support to the view that glucose acts directly on brain systems to attenuate behavioral effects of cholinergic antagonists.     

Sex differences in self-confidence: The influence of comparison to others' ability level

Previous investigators have suggested that women display lower self-confidence than men in almost all achievement settings. The validity of this suggestion is assessed in an experiment testing the impact of comparison to others upon sex differences. Male and female undergraduates, who expected to cooperate in the future with a same-sex partner of high, average, or low ability, selected a difficulty level for an achievement test, completed the test, evaluated their own performance, and estimated their future partner's probable performance. As predicted, only when subjects' future partner was highly competent did women select an easier test than men, perform less well, and compare themselves less favorably to their partner. Also, women's, but not men's, self-evaluations depended upon their partner's ability level. It is concluded that sex differences are moderated by social comparison variables. Cognitive processes that may underlie such differences are discussed.The authors wish to express their appreciation to Phoebe Ellsworth for her critical comments on this research, and to Pamela Joy, Tama Jacobson, and Thomas Hallet for serving as experimenters. Portions of this study were reported at the Eastern Psychological Association Convention, 1978.     

Glucose effects on mecamylamine-induced memory deficits and decreases in locomotor activity in mice.

Peripheral glucose administration attenuates the effects of muscarinic cholinergic antagonists on several measures, including spontaneous alternation, inhibitory avoidance, and locomotor activity. The present study examined glucose interactions with mecamylamine, a nicotinic cholinergic antagonist, on these measures. Mecamylamine (5 mg/kg, sc) significantly impaired spontaneous alternation performance. Glucose (100 mg/kg, ip) administered with mecamylamine attenuated the impairment. Treatment with hexamethonium (5 and 10 mg/kg, sc), a peripheral nicotinic blocker, did not impair performance. Pretraining treatment with mecamylamine, but not hexamethonium, significantly reduced later retention latencies on inhibitory avoidance tests. Glucose, administered with mecamylamine prior to training, significantly attenuated the impaired test performance. Mecamylamine, but not hexamethonium, significantly decreased locomotor activity. In contrast to the attenuating effects of glucose on the other measures above, glucose administered with mecamylamine potentiated the decreased locomotor activity. These findings demonstrate that glucose influences the behavioral effects of a nicotinic cholinergic antagonist in a manner generally similar to that of muscarinic cholinergic antagonists, and supports previous evidence that circulating glucose interacts with central cholinergic functions.     

Metric unfolding: Data requirement for unique solution & clarification of Schönemann's algorithm

The object of this paper is to clarify Schönemann's unfolding algorithm and, in particular, to make it clear that the equations numbered (3.2) in Schönemann's [1970] article, which define Schönemann's solutions, are not a complete set of restraints for the purpose of defining metric unfoldings. Namely, Schönemann has transformed the original equations which define an unfolding to a set of linear and non-linear equations of which he uses only the linear equations to define his solutions. Given infallible data (solution(s) exist) Schönemann's solutions will include the correct solutions. If enough data are available so that there are enough linear equations to uniquely determine a single solution, then Schönemann's solution will coincide with the correct solution. LetP andQ denote the number of elements in the two sets of points, the interset distances of which are specified by the data in the unfolding problem. Letm denote the dimensionality of the Euclidean space into which these points are to be imbedded. If only the linear equations, numbered (18) herein, are to be used, then Schönemann gives the following data requirement for the solution to be uniquely determined: Max {P – 1,Q – 1} m(m + 3)/2. If the full set of linear and nonlinear equations (18–20) are used, then the amount of data required for a solution to be locally unique is relaxed toP +Q – 1 m(m + 3)/2. Both of these results assume that the equations are independent, which has not been proved.This study was supported by General Research Support Grant RR 5612 of the Division of Research Facilities and Resources, National Institutes of Health, U.S. Public Health Service.