Improving the validity and reliability of medical-legal certifications of suicide

On a very basic level, those who study suicide are either explicitly or implicitly concerned with the certification of suicide deaths by coroners and medical examiners. Although many authors have questioned the reliability and validity of officially reported rates, these statistics continue to be quoted as fact--a potentially problematic practice for researchers who seek accurate and true causative factors for suicidal behavior. In relation to this topic, this article provides an overview of the existing vital statistics registry system and describes and proposes innovations that could ultimately improve the quality of officially reported suicide statistics.     

Different Training Procedures Recruit Either One or Two Critical Periods for Contextual Memory Consolidation, Each of Which Requires Protein Synthesis and PKA

We have used a combined genetic and pharmacological approach to define the time course of the requirement for protein kinase A (PKA) and protein synthesis in long-term memory for contextual fear conditioning in mice. The time course of amnesia in transgenic mice that express R(AB) and have genetically reduced PKA activity in the hippocampus parallels that observed both in mice treated with inhibitors of PKA and mice treated with inhibitors of protein synthesis. This PKA- and protein synthesis-dependent memory develops between 1 hr and 3 hr after training. By injecting the protein synthesis inhibitor anisomycin or the PKA inhibitor Rp-cAMPs at various times after training, we find that depending on the nature of training, contextual memory has either one or two brief consolidation periods requiring synthesis of new proteins, and each of these also requires PKA. Weak training shows two time periods of sensitivity to inhibitors of protein synthesis and PKA, whereas stronger training exhibits only one. These studies underscore the parallel dependence of long-term contextual memory on protein synthesis and PKA and suggest that different training protocols may recruit a common signaling pathway in distinct ways.     

Suicide Prevention in Adolescents (Age 12–18)

The epidemiology of adolescent suicide is summarized with particular emphasis on temporal trends by age and gender. “First-generation” prevention programs, as reviewed and critiqued by the Centers for Disease Control and Prevention, are then examined. In the absence of compelling empirically based behavioral outcome data, selective targeted “second-generation” prevention efforts are then described across the primary-secondary-tertiary continuum. These efforts are focused toward targets of individual predisposition, the social milieu, or proximal agents associated with high risk for suicidal behaviors. Finally, with an eye toward the future, current obstacles and unanswered questions are explored as they relate to opportunities and hopes for change in effecting reduced rates of these behaviors.     

Nonword repetition abilities of children who stutter: an exploratory study

Past research has suggested that children who stutter (CWS) may have less well-developed language skills than fluent children, and that such relative linguistic deficiencies may play a role in precipitating their disfluencies. However, data to support this position are primarily derived from results of standardized diagnostic inventories, which are originally designed to identify frank language impairment. Nonword repetition has emerged as a more sensitive measure of children's linguistic abilities. In this exploratory study, eight CWS (mean age 5:10, range 4:3-8:4) were compared to eight normally developing children (ND) (mean age 5:9, range 4:1-8:4) in their ability to repeat the nonwords of the Children's Test of Nonword Repetition. CWS performed more poorly than NS on measures of Number of Words Correct and Number of Phoneme Errors at all nonword lengths, although statistical differences were observed only for 3-syllable nonwords. When lexical stress of the nonwords was varied to a non-English stress pattern, all participants repeated the stimuli with less accuracy, and the CWS again exhibited more errors than NS. Fluency for the CWS group did not change systematically with increasing nonword length. These preliminary findings are interpreted in light of a number of extant theories of the underlying deficit in childhood stuttering. We conclude that children who stutter may have diminished ability to remember and/or reproduce novel phonological sequences, and that further investigation into this possibility may shed light on the emergence and characteristics of childhood stuttering. EDUCATIONAL OBJECTIVES: After completing this activity, the learner will: (1) be able to evaluate the research support for a linguistic component to stuttering; (2) describe the use of nonword repetition as an experimental and assessment device with children with SLI and children who stutter; (3) suggest future directions for research to further refine the potential role that linguistic encoding plays in the etiology and persistence of stuttering.     

Social judgments of spurious and causal relations between attributes and outcomes

People can learn about relations between attributes and outcomes by observing the attributes and outcomes of others, but, as this experiment indicates, such learning is not always veridical. Each subject received information about the ages, educations, and salaries of groups of employees in a fictitious corporation. Within a group, either age or education was related to salaries and the two attributes were either orthogonal or correlated. In each case, subjects judged the strength of the causal relation between each attribute and salaries. The results confirmed our hypothesis that observers are more likely to view a causally relevant attribute as irrelevant, and a causally irrelevant attribute as relevant, when relevant and irrelevant attributes are correlated. However, this tendency seemed to be mediated by subjects' bias to prefer education as an explanation of salary differences: That is, when age and education were correlated, subjects tended to view education as relevant even when it was irrelevant and age as irrelevant even when it was relevant. The results suggest that when attributes are correlated, factors extraneous to observed data may have a major influence on inferred attribute-outcome associations.     

Beyond the Tower of Babel: A Nomenclature for Suicidology

Suicidology finds itself confused and stagnated for lack of a standard nomenclature. This paper proposes a nomenclature for suicide-related behavior in the hope of improving the clarity and precision of communications, advancing suicidological research and knowledge, and improving the efficacy of clinical interventions.     

Effects of methylphenidate on complex cognitive processing in attention-deficit hyperactivity disorder

Three experiments were conducted to explore the effects of methylphenidate (MPH), attention-deficit hyperactivity disorder (ADHD) diagnosis, and age on performance on a complex visual-memory search task. Results showed that the effects of MPH varied with information load. On low-processing loads, all doses of MPH helped children with ADHD to improve accuracy with no cost to reaction time (RT), whereas on high loads, higher MPH doses improved error rates while slowing RT. Without medication, children with ADHD showed high error rates and slow RTs across both low and high loads, as did younger, normal control children. Because MPH slowed performance on only the most difficult, high-load conditions, it is argued that the drug improves self-regulatory ability, enabling children with ADHD to adapt differentially to high and low loads.