In defence of the Defence Mechanism Test (DMT)—a reply.

A paper by I. Zuber and B. Ekehammar in this Journal (38, 1997) is reviewed. The paper advocates that the non-veridical contents in the series of reports in the DMT should preferably be referred, not to psychoanalytic defence mechanisms, but to factors of stimulus order. The methods and the arguments of this investigation are critically examined.     

Invariance of odor strength with sniff vigor: an olfactory analogue to size constancy

Previous evidence has shown that detection threshold in humans and olfactory neural discharge rate in animal preparations both depend on flow rate of odorous vapor. But no data have been reported that show the effects of flow rate in humans on perceived odor strength at suprathreshold intensities. Subjects learned to inspire at two flow rates, one twice as great as the other, by adjusting (on a cathode ray tube) the transduced trace of a sniff-produced pressure change to match either of two target contours. They then made magnitude estimations of odor strength, while producing either weak or strong sniffs, for odorants presented over a wide range of concentrations via a specially designed sniff-bottle system. The odorant, diluted in diethyl phthalate, was n-butanol in two experiments and n-amyl acetate in two others. Subject-controlled flow rate had no effect on odor strength for either odorant. There was an apparent contradiction between these data and those on neural discharge rate that may, however, be resolved by adopting an odor constancy model: When sniff intensity varies during the olfactory exploration of an odor source, information about the rate at which odorant molecules are established at the receptor site is combined with information about sniff vigor so that the resulting percept is of invariant odor strength.     

Motion structure in five-dot patterns as a determinant of perceptual grouping

The effect of basic motion structures on perceptual grouping was studied with five-dot motion patterns. Four basic motion structures were identified in terms of proximal common and relative motion vectors. In a forced-choice situation, the observers had to decide to which of two pairs of dots a fifth critical dot seemed to belong. Thus, one of two possible three-dot units was chosen by the observers. The two possible three-dot units defined different motion structures, and the chosen motion structure was considered to have stronger grouping power than the alternative structure had. It was found that parallel common motions (perceived translation in the plane) had the strongest grouping power; these were followed by circular common motions (perceived rotation in the plane), concurrent relative motions (perceived translation in depth), and, finally, parallel relative motions (perceived rotation in depth). The results also suggested effects of proximity and orientation of axis of rotation. It is further argued that the relative grouping power of the motion structures could not solely be interpreted in terms of changes of directions and distances between the dots. Instead it is suggested that vector analysis is a fundamental perceptual activity and that basic motion structures determine grouping power.     

Towards end-to-end likelihood-free inference with convolutional neural networks

Complex simulator-based models with non-standard sampling distributions require sophisticated design choices for reliable approximate parameter inference. We introduce a fast, end-to-end approach for approximate Bayesian computation (ABC) based on fully convolutional neural networks. The method enables users of ABC to derive simultaneously the posterior mean and variance of multidimensional posterior distributions directly from raw simulated data. Once trained on simulated data, the convolutional neural network is able to map real data samples of variable size to the first two posterior moments of the relevant parameter's distributions. Thus, in contrast to other machine learning approaches to ABC, our approach allows us to generate reusable models that can be applied by different researchers employing the same model. We verify the utility of our method on two common statistical models (i.e., a multivariate normal distribution and a multiple regression scenario), for which the posterior parameter distributions can be derived analytically. We then apply our method to recover the parameters of the leaky competing accumulator (LCA) model and we reference our results to the current state-of-the-art technique, which is the probability density estimation (PDA). Results show that our method exhibits a lower approximation error compared with other machine learning approaches to ABC. It also performs similarly to PDA in recovering the parameters of the LCA model.     

Assessing the Organizational Climate for Translational Research with a New Survey Tool

Science and Engineering Ethics - Promoting translational research as a means to overcoming chasms in the translation of knowledge through successive fields of research from basic science to public...     

Use of temperature variations to combat drivers' drowsiness

The purpose of the present study was to evaluate the efficiency of temperature variations as a measure against drivers' drowsiness. A system for regulation of the air temperature in the cab was installed in two trucks. Irregular temperature reductions of about 8 degrees C were introduced. The periods between the temperature reductions varied among 5, 6, 7, and 8 min. The periods for the temperature reductions varied between 2, 4, 6, and 8 min. The system was tested with 6 drivers on 54 trips. The system was applied for periods varying between 30 to 300 min. Changes in wakefulness were analysed using subjective ratings by the lorry drivers. The application of the system significantly improved subjectively rated wakefulness. The wakefulness was rated with a questionnaire completed after 10 min. use of a cooling system and at the end of its use. Analysis showed individual differences in the usefulness of the system: 3 of the 6 truck drivers reported positive reactions to the use of the temperature cooling system.     

Associations between financial strain and the diurnal salivary cortisol secretion of long-term unemployed individuals

Objective: The study investigated the associations between self-rated financial strain and overall diurnal salivary cortisol levels, as well as secretory patterns among long-term unemployed individuals.Methods: Psychosocial and life-style variables were assessed by means of questionnaires among 85 participants (mean age 42±9 years; 56% females). Salivary cortisol was sampled on four occasions during a 24-hour period and data was analysed separately for men and women.Results: Among females, high financial strain was related to higher overall cortisol levels, and to elevated levels in the evening. These associations did not reach significance among men. Multivariate analyses showed that evening levels of cortisol were positively associated with financial strain, but largely unrelated to life-style variables and psychological distress.Conclusions: The results suggest that high financial strain influences the diurnal cortisol secretion of unemployed individuals in terms of elevated cortisol levels in the evening. The mediating mechanisms are in need of further investigation.     

Speech anxiety and rapid emotional reactions to angry and happy facial expressions

The aim was to explore whether people high as opposed to low in speech anxiety react with a more pronounced differential facial response when exposed to angry and happy facial stimuli. High and low fear participants were selected based on their scores on a fear of public speaking questionnaire. All participants were exposed to pictures of angry and happy faces while facial electromyographic (EMG) activity from the Corrugator supercilii and the Zygomaticus major muscle regions was recorded. Skin conductance responses (SCR), heart rate (HR) and ratings were also collected. Participants high as opposed to low in speech anxiety displayed a larger differential corrugator responding, indicating a larger negative emotional reaction, between angry and happy faces. They also reacted with a larger differential zygomatic responding, indicating a larger positive emotional reaction, between happy and angry faces. Consistent with the facial reaction patterns, the high fear group rated angry faces as more unpleasant and as expressing more disgust, and further rated happy faces as more pleasant. There were no differences in SCR or HR responding between high and low speech anxiety groups. The present results support the hypothesis that people high in speech anxiety are disposed to show an exaggerated sensitivity and facial responsiveness to social stimuli.     

Turning the history of medical ethics from its head onto its feet: a critical commentary on Baker and McCullough

The paper provides a critical commentary on the article by Baker and McCullough on Medical Ethic's Appropriation of Moral Philosophy. The author argues that Baker and McCullough offer a more "pragmatic" approach to the history of medical ethics that has the potential to enrich the bioethics field with a greater historical grounding and sound methodology. Their approach can help us to come to a more nuanced understanding about the way in which medical ethics has connected, disconnected, and reconnected with philosophical ideas throughout the centuries. The author points out that Baker and McCullough's model can run the danger of overemphasizing the role of medical ethicists whilst marginalizing the influence of philosophers and of other historical actors and forces. He critically reviews the two case studies on which Baker and McCullough focus and concludes that scholars need to bear in mind the levels of uncertainty and ambivalence that accompany the process of transformation and dissemination of moral values in medicine and medical practice.     

Risk Perception,Worry and Satisfaction Related to Genetic Counseling for Hereditary Cancer

In this multi center study, genetic counseling for hereditary cancer was evaluated by assessing patients’ worry, perceived risk of developing cancer and satisfaction with genetic counseling. An overall aim was to identify characteristics of vulnerable patients in order to customize genetic counseling. In addition, agreement between patients’ and counselors’ scores was measured. A total of 275 Norwegian patients were consecutively recruited, and 213 completed questionnaires before and after genetic counseling. Patients’ perceived risk decreased after the genetic counseling session. There was incongruence between risk perception expressed as a percentage and in words. Patients were significantly less worried after counseling. Higher levels of worry were predicted by low instrumental satisfaction with counseling, high degree of perceived risk of developing cancer and younger age. In conclusion, counselors met the patients’ psychological needs to a satisfactory degree during counseling. However, patients did not fully understand their risk of developing cancer.