Attitudes Toward Genetic Testing for Celiac Disease

HLA molecular typing for celiac disease (CD) is a genetic test with a high negative predictive value. The aim of this study is to explore knowledge of and attitudes towards genetic testing (GT). A 25-item questionnaire was developed by a multidisciplinary team and distributed to members of CD support groups across the United States. Respondents (n?=?1835) were mainly female (88 %), married (76 %), and college-educated (55 %), with a median age range of 31–50 years. Those who were married (82 vs 75 %, p?=?0.002), had children (82 vs 74 %, p?<?0.001), and had pursued education beyond high school (81 vs 68 %, p?=?0.004) were more likely to be aware of the availability of GT. On multivariable analysis, adjusting for age, sex, education, marital status, region of residence, and having children, college-education (OR 2.05, 95 % CI: 1.33–3.16) and having children (OR 1.56, 95 % CI: 1.15–2.11) remained significant predictors of GT awareness. A majority of patients with a personal or family history of CD planned GT for their children, and the most common concerns regarding GT were cost and impact on health care and/or insurance. In conclusion, awareness of GT is high among CD support group members. Efforts should be made to increase knowledge of GT in those with a lower educational level, and healthcare professionals should attempt to address concerns regarding GT cost and the impact of results on health care and insurance status.     

The automaticity of perceiving animacy: Goal-directed motion in simple shapes influences visuomotor behavior even when task-irrelevant

Visual processing recovers not only simple features, such as color and shape, but also seemingly higher-level properties, such as animacy. Indeed, even abstract geometric shapes are readily perceived as intentional agents when they move in certain ways, and such percepts can dramatically influence behavior. In the wolfpack effect, for example, subjects maneuver a disc around a display in order to avoid several randomly moving darts. When the darts point toward the disc, subjects (falsely) perceive that the darts are chasing them, and this impairs several types of visuomotor performance. Are such effects reflexive, automatic features of visual processing? Or might they instead arise only as contingent strategies in tasks in which subjects must interact with (and thus focus on the features of) such objects? We explored these questions in an especially direct way—by embedding such displays into the background of a completely independent “foraging” task. Subjects now moved their disc to collect small “food” dots (which appeared sequentially in random locations) as quickly as possible. The darts were task-irrelevant, and subjects were encouraged to ignore them. Nevertheless, foraging was impaired when the randomly moving darts pointed at the subjects’ disc, as compared to control conditions in which they were either oriented orthogonally to the subjects’ disc or pointed at another moving shape—thereby controlling for nonsocial factors. The perception of animacy thus influences downstream visuomotor behavior in an automatic manner, such that subjects cannot completely override the influences of seemingly animate shapes even while attempting to ignore them.     

The Catcher in the Rye and the ill member of the group: Holden Caulfield and adolescent development

This paper is an attempt to explore J. D. Salinger’s The Catcher in the Rye (1951/1958) in relation to Winnicott’s theories of adolescent development, also with regard to psychodynamic theories of symbolism, mourning, defence mechanisms and containment. I consider the significance of the novel’s protagonist and narrator Holden Caulfield. What is the reason for the enduring popularity of his voice and its influence on the tone of subsequent adolescent literature? To answer this question, I examine the role this iconic, troubled character may play in the development of the adolescent reader.     

Text‐message reminders plus incentives increase adherence to antidiabetic medication in adults with type 2 diabetes

Some adults with Type 2 diabetes mellitus have difficulty adhering to their oral medication regimens. The current study used a multiple baseline design with 3 adults with Type 2 diabetes. Medication taking was monitored remotely in real time via an electronic pill bottle. During the intervention, monetary incentives were delivered contingent on evidence of adherence to taking medication at specified times. Text‐message reminders were also sent if medication was not taken. Adherence increased for all participants. Future studies should separate the relative contributions of text‐message and incentive components of the intervention.     

Cortical Networks for Correcting Errors in Sensorimotor Synchronization Depend on the Direction of Asynchrony

Recent work provides clues that different cortical mechanisms may be employed when correcting for errors in sensorimotor synchronization that increase tap-tone asynchrony compared with those that decrease it. The authors tested this hypothesis by recording 64-channel electroencephalography while participants synchronized with an auditory metronome. We systematically introduced positive and negative phase-shift perturbations that were either liminal (10%) and subliminal (3%). We used a distributed source modeling approach to evaluate oscillatory activity and connectivity of discrete cortical sources. Three key findings support our hypothesis. First was a theta band response indicative of error detection and top-down control observed in frontomedial presupplementary motor area (pre-SMA) and anterior cingulate for liminal positive perturbations. Second was an increase in theta band coupling between the SMA and contralateral motor cortex exclusively for positive perturbations suggesting a top-down modulation of motor parameters. Third, when compared with other conditions, liminal positive perturbations result in an increase in postmovement beta rebound within contralateral primary motor cortex. The authors propose that frontomedial motor areas exert a top-down inhibitory influence over the primary motor cortex to effectively lengthen tap intervals in response to lengthening tap-tone asynchronies.     

Leading God’s People: Perceptions of Influence Among African–American Pastors

Journal of Religion and Health - Religious leaders, particularly African–American pastors, are believed to play a key role in addressing health disparities. Despite the role...