Sensitivity to sub-syllabic constituents in brain-damaged patients: evidence from word games

Two experiments were conducted to examine whether left- (LHD) and right-hemisphere-damaged (RHD) patients exhibit sensitivity to sub-syllabic constituents (i.e., onsets and codas) in the generation of nonwords, using a word games paradigm adapted from. Four groups of individuals (including LHD fluent and nonfluent aphasic patients, RHD patients and normal controls) were trained to add syllables to monosyllabic CVC nonwords either after the initial consonant (Experiment 1) or prior to the final consonant (Experiment 2) to create bisyllabic nonwords. Experimental stimuli consisting of CCVC or CVCC nonwords tested whether participants would preserve or split the onset and coda constituents in producing the novel bisyllabic nonwords. Results revealed that the majority of subjects demonstrated sensitivity to the sub-syllabic constituents, preserving the onsets and codas. The fluent aphasic patients exhibited a greater than normal tendency to split the onset and coda constituents; however, the small number of individuals in that group whose data met inclusion criteria limits the conclusions that may be drawn from these findings. The results are discussed in relation to theories of phonological deficits in aphasia.     

The effects of stress on dna repair capacity

Abstract

Research has shown that lymphocytes of high-distress patients have reduced DNA repair relative to that of low-distress patients and healthy controls. Furthermore, deficits in repair are associated with an increased risk of cancer. Using and academic stress model, we hypothesized that students would exhibit lower levels of Nucleotide Excision Repair (NER) during a stressful exam period when compared to a lower stress period. Participants were 19 healthy graduate level students. NER was measured in lymphocytes using the unscheduled DNA synthesis (UDS) assay with slide autoradiography. Contrary to prediction, mean values for NER significantly increased during the higher stress period relative to the lower stress period controlling for background differences in repair. Furthermore, lymphocytes had significantly increased repair of endogenous damage during the higher stress period. Stress appears to directly increase DNA repair. Additionally, stress may increase DNA repair indirectly by increasing damage to DNA.     

Effect of Prenatal Androgen on Adult Personality: Greater Openness with More Female-Typical 2D:4D Digit Ratios

One hundred seven university community participants (71 female, 36 male) were evaluated on the five personality factors (NEO-FFI), and finger lengths were measured to determine the ratio of the second to fourth digit (2D:4D). It is well-established that 2D:4D ratios are an index of prenatal androgenic activity. Sex differences were found such that the men had lower 2D:4D ratios than the women for both the left and right hands, and the women indicated greater Neuroticism than the men, as reported by others. Most interestingly, greater Openness was significantly associated with more female-typical (higher) 2D:4D ratios for the entire sample. This was significant for the male sample alone, and was found at a trend level in the female sample alone.     

Behavior,process, and scale: Comments on Shimp (2020), “Molecular (moment-to-moment) and molar (aggregate) analyses of behavior”

If we study the behavior of organisms, we must understand the ontological status of both “organism” and “behavior.” A living organism maintains itself alive by constantly interacting with the environment, taking in energy and discarding waste. Ontologically, an organism is a process. Its interactions with the environment, which constitute its behavior, are processes also, because the parts of any process are themselves processes. Processes serve functions, and the function of a process must be part of its identity. A process, by definition, extends in time. Time is the fundamental and universal measure of behavior. All processes have the property of scale. Activities of an organism have parts that are themselves activities on a smaller time scale. Scale varies continuously, and behavior may be studied on as large or as small a time scale as seems necessary. When researchers refer to the “structure” of behavior, they refer to smaller-scale activities. Attaching a switch to a lever or key is convenient, but one should never confuse operation of a switch with a unit of behavior. Shimp's (2020) “molecular” measures are small-scale measures. The molecular view based on discrete events has outlived its usefulness and should be replaced by a multiscale molar paradigm.     

Resistance to extinction versus extinction as discrimination

The hypothesis that response strength might be measured by persistence of responding in the face of extinction was discredited in the 1960s because experiments showed that responding persists longer following intermittent reinforcers than following continuous reinforcers. Instead, researchers proposed that the longer persistence following intermittent reinforcers arises because intermittent reinforcement more closely resembles extinction—a discrimination theory. Attention to resistance to extinction revived because one observation seemed to support the persistence hypothesis: Following training on a multiple schedule with unequal components, responding usually persisted longer in the formerly richer component than in the formerly lean component. This observation represents an anomaly, however, because results with single schedules and concurrent schedules contradict it. We suggest that the difference in results arises because the multiple-schedule procedure, while including extensive training on stimulus discrimination, includes no training on discrimination between food available and food unavailable, whereas comparable single- and concurrent-schedule procedures include such training with repeated extinction. In Experiment 1, we replicated the original result, and in Experiment 2 showed that when the multiple-schedule procedure includes training on food/no-food discrimination, extinction following multiple schedules contradicts behavioral momentum theory and agrees with the discrimination theory and research with single and concurrent schedules.