A neuropsychological theory of positive affect and its influence on cognition.

Positive affect systematically influences performance on many cognitive tasks. A new neuropsychological theory is proposed that accounts for many of these effects by assuming that positive affect is associated with increased brain dopamine levels. The theory predicts or accounts for influences of positive affect on olfaction, the consolidation of long-term (i.e., episodic) memories, working memory, and creative problem solving. For example, the theory assumes that creative problem solving is improved, in part, because increased dopamine release in the anterior cingulate improves cognitive flexibility and facilitates the selection of cognitive perspective.     

Modeling stage-sequential change in ordered categorical responses

Although few would dispute the usefulness of looking at behavioral change from a stage-sequential perspective, until recently the lack of appropriate modeling techniques has hampered rigorous empirical tests of stage theories. In particular, for behavioral measurements that are ordinal, there is a need for methods that represent the underlying change processes in the form of qualitative and discontinuous shifts. This article introduces a stage-sequential ordinal model by postulating that at any point in time there are a finite number of latent stages. Panel members may shift among these stages over time. The authors show that the stage-sequential model provides a general approach for both the analysis of ordinal time-dependent data and tests of various competing theories and hypotheses about psychological change processes. An analysis of a 5-year study concerning attitudes toward alcohol consumption by teenagers is presented to illustrate the modeling approach.     

Labelled Resolution for Classical and Non-classical Logics

Resolution is an effective deduction procedure for classical logic. There is no similar "resolution" system for non-classical logics (though there are various automated deduction systems). The paper presents resolution systems for intuistionistic predicate logic as well as for modal and temporal logics within the framework of labelled deductive systems. Whereas in classical predicate logic resolution is applied to literals, in our system resolution is applied to L(abelled) R(epresentation) S(tructures). Proofs are discovered by a refutation procedure defined on LRSs, that imposes a hierarchy on clause sets of such structures together with an inheritance discipline. This is a form of Theory Resolution. For intuitionistic logic these structures are called I(ntuitionistic) R(epresentation) S(tructures). Their hierarchical structure allows the restriction of unification of individual variables and/or constants without using Skolem functions. This structures must therefore be preserved when we consider other (non-modal) logics. Variations between different logics are captured by fine tuning of the inheritance properties of the hierarchy. For modal and temporal logics IRS's are extended to structures that represent worlds and/or times. This enables us to consider all kinds of combined logics.     

The epidemiology of Wilson's disease in the German Democratic Republic and current problems from the viewpoint of population genetics

Between 1949 and Nov. 30, 1977 a total of 123 cases of Wilson's disease have been registered in the GDR. Using the available statistics the incidence rate of the disease is assumed to be about 2.9/100,000, the gene frequency approx. 0.53 per cent and the heterozygote incidence 1.05 per cent, supposing that the Hardy-Weinberg law applies to a large extent. Conclusions are drawn from the available material with a view to detection of the disease infuture and to genetic family counselling.     

Separate and joint scaling of perceived odor intensity ofn-butanol and hydrogen sulfide

To determine which combination of scaling method and experimental procedure is optimal for measuring perceived odor intensity, the intensity perception of one odorous substance was scaled both separately and together with a second odorous substance in the same session. The methods used were magnitude estimation with and without a standard reference and cross-modal matching with finger span. The results show that separate and joint scalings ofn-butanol and H₂S give identical scales, regardless of scaling method. Different results are obtained in magnitude estimations with a homoquality, a heteroquality, and no standard. From these results, one would not expect to find a single true power function independent of method. Cross-modal matching with finger span may be the best choice for odor intensity scaling, since it results in the widest response range, thereby giving the best resolution.     

A domain‐specific risk‐attitude scale: measuring risk perceptions and risk behaviors

We present a psychometric scale that assesses risk taking in five content domains: financial decisions (separately for investing versus gambling), health/safety, recreational, ethical, and social decisions. Respondents rate the likelihood that they would engage in domain‐specific risky activities (Part I). An optional Part II assesses respondents' perceptions of the magnitude of the risks and expected benefits of the activities judged in Part I. The scale's construct validity and consistency is evaluated for a sample of American undergraduate students. As expected, respondents' degree of risk taking was highly domain‐specific, i.e. not consistently risk‐averse or consistently risk‐seeking across all content domains. Women appeared to be more risk‐averse in all domains except social risk. A regression of risk taking (likelihood of engaging in the risky activity) on expected benefits and perceived risks suggests that gender and content domain differences in apparent risk taking are associated with differences in the perception of the activities' benefits and risk, rather than with differences in attitude towards perceived risk. Copyright © 2002 John Wiley & Sons, Ltd.     

Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1

The protein synthesis-dependent form of hippocampal long-term potentiation (late-LTP) is thought to underlie memory. Its induction requires a distinct stimulation strength, and the common opinion is that only repeated tetani result in late-LTP whereas as single tetanus only reveals a transient early-LTP. Properties of LTP induction were compared to learning processes where repetition is often the prerequisite for a long-lasting memory. However, also single events can lead to manifested memory. If LTP subserves processes of learning, similar results should be detectable for LTP. Here we show that a single tetanus is sufficient to induce late-LTP requiring dopaminergic co-transmission during induction.     

The 'hard problem' and the quantum physicists. Part 2: Modern times

This is the second part of a review of the work of quantum physicists on the 'hard part' of the problem of mind. After an introduction which sets the scene and a brief review of contemporary work on the neural correlates of consciousness (NCC) the work of four prominent modern investigators is examined: J.C. Eccles/Friedrich Beck; Henry Stapp; Stuart Hameroff/Roger Penrose; David Bohm. With the exception of David Bohm, all attempt to show where in the brain's microstructure quantum affects could make themselves felt. It is reluctantly concluded that none have neurobiological plausibility. They are all instances, to paraphrase T.H. Huxley, of a beautiful hypothesis destroyed by ugly facts. David Bohm does not attempt to fit his new quantum physics to contemporary neurobiology but instead asks for a radical rethink of our conventional scientific paradigm. He suggests that we should look towards developing a 'pan-experientialism' or 'dual-aspect monism' where consciousness goes 'all the way down' and that the 'hard problem' is not soluble within the framework of ideas provided by 'classical' natural science.