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One of the most important achievements in understanding the brain is that the emergence of complex behavior is guided by the
activity of brain networks. To fully apply this theoretical approach fully, a method is needed to extract both the location
and time course of the activities from the currently employed techniques. The spatial resolution of fMRI received great attention,
and various non-conventional methods of analysis have previously been proposed for the above-named purpose. Here, we briefly
outline a new approach to data analysis, in order to extract both spatial and temporal activities from fMRI recordings, as
well as the pattern of causality between areas. This paper presents a completely data-driven analysis method that applies
both independent components analysis (ICA) and the Granger causality test (GCT), performed in two separate steps. First, ICA
is used to extract the independent functional activities. Subsequently the GCT is applied to the independent component (IC)
most correlated with the stimuli, to indicate its causal relation with other ICs. We therefore propose this method as a promising
data-driven tool for the detection of cognitive causal relationships in neuroimaging data. 相似文献
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Kremin H Akhutina T Basso A Davidoff J De Wilde M Kitzing P Lorenz A Perrier D van der Sandt-Koenderman M Vendrell J Weniger D Apt P Arabia C De Bleser R Cohen H Corbineau M Dolivet MC Hirsh K Lehoux E Metz-Lutz MN Montañes P Plagne S Polonskaya N Sirois M Stachowiak F Sweeney T Vish-Brink E 《Brain and cognition》2003,53(2):243-246
The well established effect of word frequency on adult's picture naming performance is now called into question. This is particularly true for variables which are correlated with frequency, as is the case of age of word acquisition. Since the work of [Carrol and White, 1973] there is growing agreement among researchers to confer an important role in lexical access to this variable. Indeed, it has been shown ( [Hodgson and Ellis, 1998]) that for normal English-speaking adults only the variables 'age-of-acquisition' and 'name agreement' are independent predictors of naming success among the various variables considered. However, when brain-damaged subjects with and without degenerative pathologies are studied, word frequency and word length as well as concept familiarity all give significant effects ( [Hirsh and Funnell, 1995]; [Lambon Ralph et al., 1998]; [Nickels and Howard, 1995]). Finally, it has been suggested that the production of specific error types may be related to such variables. According to [Nickels and Howard, 1994] the production of semantic errors is specifically affected by 'imageability' and in the recent study by [Kremin et al., 2001] 'age of acquisition' predicts (frank) word finding difficulties. 相似文献
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A fMRI study of word retrieval in aphasia 总被引:9,自引:0,他引:9
Perani D Cappa SF Tettamanti M Rosa M Scifo P Miozzo A Basso A Fazio F 《Brain and language》2003,85(3):357-368
The neural mechanisms underlying recovery of cognitive functions are incompletely understood. Aim of this study was to assess, using functional magnetic resonance (fMRI), the pattern of brain activity during covert word retrieval to letter and semantic cues in five aphasic patients after stroke, in order to assess the modifications of brain function which may be related to recovery. Four out of five patients had undergone language recovery, according to standard testing, after at least 6 months of rehabilitation. The cerebral activation of each patient was evaluated and compared with the activation pattern of normal controls studied with the same fMRI paradigm. In the patients, the pattern of brain activation was influenced by the site and extent of the lesion, by the degree of recovery of language, as reflected by task performance outside the scanner, and by task requirements. In the case of word retrieval to letter cues, a good performance was directly related to the activation in Broca's area, or in the right-sided homologue. On the other hand, in the case of semantic fluency, the relationship between performance level and activation was less clear-cut, because of extensive recruitment of frontal areas in patients with defective performance. These findings suggest that the performance in letter fluency is dependent on the integrity of the left inferior frontal cortex, with the participation of the homologous right hemispheric region when the left inferior frontal cortex is entirely of partially damaged. Semantic fluency, which engages the distributed network of semantic memory, is also associated with more extensive patterns of cerebral activation, which however appear to reflect retrieval effort rather than retrieval success. 相似文献
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Current models of prospective timing hypothesize that estimated duration is influenced either by the attentional load or by the short-term memory requirements of a concurrent nontemporal task. In the present study, we addressed this issue with four dual-task experiments. In Exp. 1, the effect of memory load on both reaction time and temporal production was proportional to the number of items of a visuospatial pattern to hold in memory. In Exps. 2, 3, and 4, a temporal production task was combined with two visual search tasks involving either pre-attentive or attentional processing. Visual tasks interfered with temporal production: produced intervals were lengthened proportionally to the display size. In contrast, reaction times increased with display size only when a serial, effortful search was required. It appears that memory and perceptual set size, rather than nonspecific attentional or short-term memory load, can influence prospective timing. 相似文献
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When working memory updating requires updating: Analysis of serial position in a running memory task
This study aimed to investigate updating in working memory (WM), analyzing the effects of task demand and memory resources on serial position curve (SPC), in a running memory task with slow pace presentation and a probed recognition procedure. These task conditions were supposed to produce an easier WM updating task, which may allow evidencing whether the task is performed through an active or a passive updating. 相似文献
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Ricardo Basso Garcia Irene C. Mammarella Doriana Tripodi Cesare Cornoldi 《The British journal of developmental psychology》2014,32(1):17-33
This study examined forward and backward recall of locations and colours and the binding of locations and colours, comparing typically developing children – aged between 8 and 10 years – with two different groups of children of the same age with learning disabilities (dyslexia in one group, non‐verbal learning disability [NLD] in the other). Results showed that groups with learning disabilities had different visuospatial working memory problems and that children with NLD had particular difficulties in the backward recall of locations. The differences between the groups disappeared, however, when locations and colours were bound together. It was concluded that specific processes may be involved in children in the binding and backward recall of different types of information, as they are not simply the resultant of combining the single processes needed to recall single features. 相似文献
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