The effect of a non-steroidal anti-inflammatory drug on two important predictors for accidental falls: Postural balance and manual reaction time. A randomized, controlled pilot study

Accidental falls in older individuals are a major health and research topic. Increased reaction time and impaired postural balance have been determined as reliable predictors for those at risk of falling and are important functions of the central nervous system (CNS). An essential risk factor for falls is medication exposure. Amongst the medications related to accidental falls are the non-steroidal anti-inflammatory drugs (NSAIDs). About 1-10% of all users experience CNS side effects. These side effects, such as dizziness, headaches, drowsiness, mood alteration, and confusion, seem to be more common during treatment with indomethacin. Hence, it is possible that maintenance of (static) postural balance and swift reactions to stimuli are affected by exposure to NSAIDs, indomethacin in particular, consequently putting older individuals at a greater risk for accidental falls. The present study investigated the effect of a high indomethacin dose in healthy middle-aged individuals on two important predictors of falls: postural balance and reaction time. Twenty-two healthy middle-aged individuals (59.5 ± 4.7 years) participated in this double-blind, placebo-controlled, randomized crossover trial. Three measurements were conducted with a week interval each. A measurement consisted of postural balance as a single task and while concurrently performing a secondary cognitive task and reaction time tasks. For the first measurement indomethacin 75 mg (slow-release) or a visually identical placebo was randomly assigned. In total, five capsules were taken orally in the 2.5 days preceding assessment. The second measurement was without intervention, for the final one the first placebo group got indomethacin and vice versa. Repeated measures GLM revealed no significant differences between indomethacin, placebo, and baseline in any of the balance tasks. No differences in postural balance were found between the single and dual task conditions, or on the performance of the dual task itself. Similarly, no differences were found on the manual reaction time tasks. The present study showed that a high indomethacin dose does not negatively affect postural balance and manual reaction time in this healthy middle-aged population. Although the relatively small and young sample limits the direct ability to generalize the results to a population at risk of falling, the results indicate that indomethacin alone is not likely to increase fall risk, as far as this risk is related to abovementioned important functions of the CNS, and not affected by comorbidities.     

Dimensions and Correlates of Attention Deficit/Hyperactivity Disorder and Sluggish Cognitive Tempo

The present study examined Sluggish Cognitive Tempo (SCT) in relation to ADHD symptoms, clinical diagnosis, and multiple aspects of adjustment in a clinical sample. Parent and teacher reports were gathered for 322 children and adolescents evaluated for behavioral, emotional, and/or learning problems at a university clinic. Confirmatory factor analyses (CFA) supported the presence of three separate, but correlated factors (SCT, inattention, and hyperactivity/impulsivity) in both parent and teacher ratings. As expected, SCT symptoms were greatest in youth with ADHD Inattentive type, but were also found in non-ADHD clinical groups. SCT symptoms were related to inattention, internalizing, and social problems across both parent and teacher informants; for parent reports, SCT was also related to more externalizing problems. Findings support the statistical validity of the SCT construct, but its clinical utility is still unclear.     

A theoretical upgrade of the concept of parental psychological control: Proposing new insights on the basis of self-determination theory

Psychological control refers to manipulative parental behavior that intrudes upon the child’s psychological world. During the past decade, socialization research has consistently demonstrated the negative effects of psychologically controlling parenting on children’s and adolescents’ development. However, there has been relatively little advance in our conceptual understanding of this parenting construct. The present overview aims to enrich the theoretical background of the concept of psychological control by relating it to concepts used in self-determination theory. It is argued that this theoretical background allows for (a) a clearer definition of the concept of psychological control, (b) a more refined understanding of the dynamics involved in psychologically controlling parenting, and (c) a greater insight regarding its generalization across age and cultures. Directions for future research are formulated with respect to each of these three issues.     

Capturing autonomy,competence, and relatedness at work: Construction and initial validation of the Work‐related Basic Need Satisfaction scale

The satisfaction of the basic psychological needs for autonomy, competence, and relatedness, as defined in Self‐Determination Theory, has been identified as an important predictor of individuals' optimal functioning in various life domains. The study of work‐related need satisfaction seems, however, hampered by the lack of a validated measure. To assist future research, the present study aimed to develop and validate a Work‐related Basic Need Satisfaction scale (W‐BNS). Using four Dutch‐speaking samples, evidence was found for the three‐factor structure of the scale, the discriminant validity, and the reliability of the three need satisfaction subscales as well as their criterion‐related and predictive validity. The W‐BNS may therefore be considered as a promising tool for future research and practice.     

The personality‐identity interplay in emerging adult women: convergent findings from complementary analyses

The present study examined whether identity development occurs in tandem with personality development in emerging adulthood. Three‐wave longitudinal data on a sample of 351 female college students were used to answer questions about stability and change, direction of effects, and interrelated developmental trajectories. Four identity dimensions (i.e. commitment making, exploration in breadth, identification with commitment, and exploration in depth) and the Big Five were assessed. Identity and personality were found to be meaningfully related at the level of both the time‐specific adjacent measures and the underlying developmental trajectories with various degrees of convergence. Cross‐lagged analyses substantiated reciprocal influences and Latent Growth Curve Modelling substantiated common developmental pathways that partially mirrored the concurrent relations. Implications and suggestions for future research are discussed. Copyright © 2006 John Wiley & Sons, Ltd.     

Impulsivity and Behavior-Dependent Life Events Mediate the Relationship of Reward Sensitivity and Depression,but Not Hypomania,Among at-Risk Adolescents

Both reward sensitivity and impulsivity are related to the development and course of bipolar spectrum disorders (BSDs) and have been implicated in other disorders and negative functional outcomes such as substance abuse, obesity, suicidal behaviors, and risk-taking. Furthermore, according to the transactional component of the Behavioral Approach System (BAS)/reward hypersensitivity theory of BSDs, people with reward hypersensitivity should experience more BAS-relevant events, and thus, are more vulnerable to mood symptoms and episodes via stress generation. Impulsivity may exacerbate stress generation in individuals at risk for BSDs based on exhibiting reward hypersensitivity. The current study examined whether impulsivity explained the generation of stress and subsequent mood symptoms beyond what is explained by reward sensitivity alone. Participants were 131 Moderate BAS and 216 High BAS sensitivity adolescents (M = 18.43 years, SD = 1.40), who completed baseline measures of reward sensitivity and impulsivity, as well as follow-up measures of life events and mood symptoms. Results from linear regression analyses indicated that higher baseline impulsivity predicted behavior-dependent, but not behavior-independent, life events. Furthermore, path analyses suggested that the effect of BAS group on depression symptoms at next follow-up was partly explained via the indirect effect of impulsivity and negative behavior-dependent life events. We did not find these effects for behavior-independent or positive-dependent events or for prediction of hypomanic symptoms. The findings suggest that impulsivity may account for stress generation of negative events that precede depression.     

Maladaptive perfectionism as an intervening variable between psychological control and adolescent depressive symptoms: a three-wave longitudinal study.

Maladaptive perfectionism has been postulated as an intervening variable between psychologically controlling parenting and adolescent internalizing problems. Although this hypothesis has been confirmed in a number of cross-sectional studies, it has not yet been examined from a longitudinal perspective. Findings from this 3-wave longitudinal study show that parental psychological control (as indexed by parent and adolescent reports) at age 15 years predicted increased levels of maladaptive perfectionism 1 year later. Maladaptive perfectionism, in turn, predicted increased levels of adolescent depressive symptoms again 1 year later and acted as a significant intervening variable between parental psychological control at Time 1 and depressive symptoms at Time 3. Multigroup analyses show that the model tested was consistent across gender for paternal psychological control but not for maternal psychological control. Suggestions for future research are outlined.     

Pi on Earth, or Mathematics in the Real World

We explore aspects of an experimental approach to mathematical proof, most notably number crunching, or the verification of subsequent particular cases of universal propositions. Since the rise of the computer age, this technique has indeed conquered practice, although it implies the abandonment of the ideal of absolute certainty. It seems that also in mathematical research, the qualitative criterion of effectiveness, i.e. to reach one’s goals, gets increasingly balanced against the quantitative one of efficiency, i.e. to minimize one’s means/ends ratio. Our story will lead to the consideration of some limit cases, opening up the possibility of proofs of infinite length being surveyed in a finite time. By means of example, this should show that mathematical practice in vital aspects depends upon what the actual world is like.

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The intergenerational transmission of authoritarianism: The mediating role of parental goal promotion

This study examined the intergenerational transmission of adolescent authoritarian submission (Right-Wing Authoritarianism or RWA) and authoritarian dominance (Social Dominance Orientation or SDO). It was hypothesized that the type of goals that parents promote (i.e., conservation versus openness to change and extrinsic versus intrinsic goal promotion) would mediate any direct association between parents’ and adolescents’ authoritarian attitudes. This hypothesis was examined in a sample of middle adolescents and their parents. First, a significant parent–child concordance was found for RWA and SDO. Second, whereas parental RWA predicted parental promotion of conservation goals (rather than openness to change goals) as well as the promotion of extrinsic goals (rather than intrinsic goals), parental SDO predicted parental promotion of extrinsic goals only. Third, process analyses showed that, whereas parental conservation goal promotion mediates the relationship between parent and child RWA, parental extrinsic goal promotion mediates the relationship between parent and child SDO.