The Use of Psychoeducation for a Patient with Hepatitis C and Psychiatric Illness in Preparation for Antiviral Therapy: A Case Report and Discussion

The standard of care treatment for chronic hepatitis C viral infection (HCV) is a combination of pegylated interferon alfa and ribavirin for 24-48?weeks according to the virus genotype. This therapy is known to have multiple neuropsychiatric side effects. A major concern when evaluating a patient for HCV treatment with a known history of a psychiatric disorder is the risk that the patient's psychiatric disorder will flare or become unmanageable. The possibility of precipitating depression, confusion, mania, psychosis, hallucinations, or suicidal ideation or attempt is frequently an obstacle to treatment. We present the case of a 50?year-old man with HCV and an extensive psychiatric history involving alcoholism, depression, and suicidality who participated in a psychoeducation group to help prepare him for treatment with pegylated interferon alfa/ribavirin therapy. Though the patient derived much benefit from the psychoeducation group, by the time of evaluation for HCV treatment two months after the group ended he had relapsed back into a depressive episode with suicidal thoughts. His acute psychiatric status made him unacceptable for pegylated interferon alfa/ribavirin therapy. Psychoeducation groups show promise for helping patients with chronic medical illness to be ready for and endure intensive medical treatment that has substantial psychiatric side effects. The challenge is to help patients overcome barriers to treatment, particularly psychosocial problems, because available treatments are increasingly effective.     

Saving Strawson: Evil and Strawsonian Accounts of Moral Responsibility

Almost everyone allows that conditions can obtain that exempt agents from moral responsibility—that someone is not a morally responsible agent if certain conditions obtain. In his seminal “Freedom and Resentment,” Peter Strawson denies that the truth of determinism globally exempts agents from moral responsibility. As has been noted elsewhere, Strawson appears committed to the surprising thesis that being an evil person is an exempting condition. Less often noted is the fact that various Strawsonians—philosophers sympathetic with Strawson’s account of moral responsibility—at least appear to have difficulty incorporating evil persons into their accounts of moral responsibility. In what follows, I argue that Strawson is not committed to supposing that being evil is an exempting condition—at least, that he can allow that evil persons are morally responsible agents.     

Daily patterns of communication and contact between Italian early adolescents and their friends

The goal of the present study was to explore patterns of communication between adolescents and their friends across both "online" and "in-person" contexts. The participants were adolescents (n?=?727) aged 11-16 years attending middle schools in urban and rural areas of Italy. Participants completed daily logs of their in-person and online contacts with friends for 20 consecutive school days. Girls reported more total contacts with their friends than did boys as well as friendships that were closer and more intimate. However, boys indicated more contact than girls via electronic communication and online. Contacts with peers in general were less frequent among the older participants, perhaps because of increasing academic demands. Participants who complemented in-person contact with friends with electronic contact were less lonely than their counterparts who were less versatile in accessing different modalities of making contact with friends.     

Communication,Influence, and Informational Asymmetries among Voters

The costs of political information vary dramatically across individuals, and these costs help explain why some individuals become politically expert while others demonstrate low levels of political knowledge and awareness. An attractive alternative, particularly for those with high information costs, is to rely on information and advice taken from others who are politically expert. This paper focuses on the complications that arise when the informant and the recipient do not share preferences. A series of small group experiments show that subjects tend to weight expertise more heavily than shared preferences in selecting informants, thereby exposing themselves to diverse views and biased information. Experimental subjects employ several heuristic devices in evaluating the reliability of this information, but depending on their own levels of information, these heuristics often lead subjects either to dismiss advice that conflicts with their own prior judgments or to dismiss advice that comes from an informant with divergent preferences. Hence these heuristics produce important consequences for patterns of political influence, as well as reducing the potential for political change.     

Perceptual load modulates the processing of distractors presented at task-irrelevant locations during the attentional blink

The distribution of attention in both space and time is critical for processing our dynamic environment. Studies of spatial attention suggest that the distribution of attention is decreased when the perceptual load of a task increases, resulting in decreased processing of task-irrelevant distractors. Studies of the attentional blink (AB) suggest that the temporal distribution of attention also influences distractor processing, such that distractor processing increases during the AB relative to outside the AB (Jiang & Chun, 2001). Two experiments are reported in which the extent to which the difficulty of the first target task (T1) modulates the processing of task-irrelevant distractors during the AB was tested. To investigate this issue, both the first and second target tasks (T1 and T2) required identifying a central stimulus that was flanked by low-load or high-load distractors. Consistent with previous studies of the AB, there was evidence of more distractor processing during the AB than outside the AB. Critically, however, the interference caused by distractors presented simultaneously with T2 during the AB was reduced when T1 perceptual load was high relative to when it was low. These results suggest that increasing T1 perceptual load decreases distractor processing during the AB and that perceptual processes influence both the temporal and spatial distribution of attention.     

Harmonising natural deduction

Prawitz proved a theorem, formalising ‘harmony’ in Natural Deduction systems, which showed that, corresponding to any deduction there is one to the same effect but in which no formula occurrence is both the consequence of an application of an introduction rule and major premise of an application of the related elimination rule. As Gentzen ordered the rules, certain rules in Classical Logic had to be excepted, but if we see the appropriate rules instead as rules for Contradiction, then we can extend the theorem to the classical case. Properly arranged there is a thoroughgoing ‘harmony’, in the classical rules. Indeed, as we shall see, they are, all together, far more ‘harmonious’ in the general sense than has been commonly observed. As this paper will show, the appearance of disharmony has only arisen because of the illogical way in which natural deduction rules for Classical Logic have been presented.     

Proceedings of the American Psychological Association for the legislative year 2007: minutes of the annual meeting of the Council of Representatives and minutes of the meetings of the Board of Directors

Provides the minutes of the Annual Meeting of the Council of Representatives February 16-18, 2007, Washington, DC, and August 9 and 13, 2007, San Francisco, CA, and minutes of the February, June, August, and December 2007 meetings of the Board of Directors. These minutes are the official record of the actions of the American Psychological Association taken during the year by both the Board of Directors (the Board) and the Council of Representatives (Council). The main topical headings are I. Minutes of Meetings; II. Elections, Awards, Membership, and Human Resources; III. Ethics; IV. Board of Directors; V. Divisions and State, Provincial, and Territorial Psychological Associations; VI. Organization of the APA; VII. Publications and Communications; VIII. Convention Affairs; IX. Educational Affairs; X. Professional Affairs; XI. Scientific Affairs; XII. Public Interest; XIII. Ethnic Minority Affairs; XIV. International Affairs; XV. Central Office; and XVI. Financial Affairs.     

Inequity in Hindu–Muslim Riots: A Test of Two Biases1

During the past 50 years, substantially more Muslims than Hindus have died in riots in India. This study examined and found support for 2 possible individual‐level reasons that are consistent with this disproportionate number of deaths. First, Hindus, compared to Muslims, considered historical incidents to be more important for contemporary Hindu–Muslim relations. Second, Hindus showed an ultimate group bias in that they generally valued Hindu lives more than Muslim lives, whereas Muslims showed no difference in the valuation of Hindu and Muslim lives. Together, these results are consistent with an equity notion that Hindus consider as relevant input factors both historical incidents and perceptions that in‐group members’ lives are more valuable than are out‐group members’ lives.     

Appetitive memory reconsolidation depends upon NMDA receptor-mediated neurotransmission

Memory persistence is a dynamic process involving the reconsolidation of memories after their reactivation. Reconsolidation impairments have been demonstrated for many types of memories in rats, and signaling at N-methyl-d-aspartate (NMDA) receptors appears often to be a critical pharmacological mechanism. Here we investigated the reconsolidation of appetitive pavlovian memories reinforced by natural rewards. In male Lister Hooded rats, systemic administration of the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo{a,d}cyclohepten-5,10-imine maleate (MK-801, 0.1 mg/kg i.p.) either before or immediately following a brief memory reactivation session abolished the subsequent acquisition of a new instrumental response with sucrose conditioned reinforcement. However, only when injected prior to memory reactivation was MK-801 effective in disrupting the maintenance of a previously-acquired instrumental response with conditioned reinforcement. These results demonstrate that NMDA receptor-mediated signaling is required for appetitive pavlovian memory reconsolidation.     

Long-term effects of prior cocaine exposure on Morris water maze performance

Cocaine addiction is associated with long-term cognitive alterations including deficits on tests of declarative/spatial learning and memory. To determine the extent to which cocaine exposure plays a causative role in these deficits, adult male Long-Evans rats were given daily injections of cocaine (30 mg/kg/day x 14 days) or saline vehicle. Three months later, rats were trained for 6 sessions on a Morris water maze protocol adapted from Gallagher, Burwell, and Burchinal [Gallagher, M., Burwell, R., & Burchinal, M. (1993). Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behavioral Neuroscience, 107, 618-626]. Rats given prior cocaine exposure performed similarly to controls on training trials, but searched farther from the platform location on probe trials interpolated throughout the training sessions and showed increased thigmotaxis. The results demonstrate that a regimen of cocaine exposure can impair Morris water maze performance as long as 3 months after exposure. Although the impairments were not consistent with major deficits in spatial learning and memory, they may have resulted from cocaine-induced increases in stress responsiveness and/or anxiety. Increased stress and anxiety would be expected to increase thigmotaxis as well as cause impairments in searching for the platform location, possibly through actions on ventral striatal dopamine signaling.